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Awful horrible bad shit is happening in the USA right now, if you are afraid of your fucking feelings getting hurt this isn't the website for you. ×

PsychMike

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  1. I realize this is not about mail in voting, but unfounded allegations of voting fraud abound. What is the common thread here?
  2. John T. Scopes Monkey Trial: the Sequel, IMO.
  3. So the federal government has been spending lots of $ advertising on Twitter and FB?
  4. Hydroxychloroquine-induced photosensitivity is a real thing.
  5. Does anyone know of a way to have your Twitter account auto-block anyone with certain shit in their profile, like #WWG1WGA? Sorry, but checked my settings before and couldn't figure it out. I'm actually proud to admit I am only semi-literate in twittersphereshit.
  6. It also reminded me of this from the Galveston paper: “We haven’t noticed anything different other than having to stand in line at the restaurant,” said David McGinnis, who drove to Galveston from Belton, about five hours away, on Friday. His family’s trip to Galveston this weekend was a small makeup for a canceled April trip to Mexico. “Personally, I feel if God’s going to call you home, he’s going to call you home here, at home or in Canada,” McGinnis said. “So it doesn’t matter. But, I mean, we’re not being stupid and shaking hands with everybody we meet.” It's as if they are all listening to the same talk radio shows.
  7. Perhaps we could get Tom Selleck to straighten things up, then? He's been around long enough to know what's what.
  8. There are pass catchers and there are Pluckers. Pluckers really know how to wing it, IMO.
  9. During my early football days (late 70s-early 80's) I was told that the reason we used 40 yard dash to time football player is because that's the distance where we typically reach maximal speed. That said, I would wager that every individual has their own curve. Take a look at this acceleration curve from the world's fastest sprinter. He continues to accelerate well beyond 40m, although the increment is smaller moving to the right. I would imagine that could explain the disparity of a person's 200m time vs 40. I wouldn't trust any conversion table, because I imagine a well-designed study generating such table would contain sizable error bars.
  10. From early on in this pandemic, when people started to discuss HCQ with or without AZ, they would cite the known safety data. But what they failed to acknowledge or understand, is that that safety data was not reported from Covid-19 patients. Yes, there can be real differences in toxicity. It's what we in the clinical pharmacy world refer to as drug-disease interactions. I didn't predict problems, I was concerned that people were overlooking potential problems that had not been studied under controlled conditions. The more safe people are convinced it is, the higher the potential risk for therapeutic misadventures. Fast forward to "The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin" by Chorin et al. April 24, 2020 in Nature Medicine (I accessed it at nature.com) The following excerpt provides preliminary evidence that yes, active Covid infection (at least higher severity cases) put patients at higher risk of toxicity. Thankfully, there were no incidents of Torsade de Pointes. Deaths in the HCQ/AZ patients were not related to arrhythmias and their ECGs were normal. But let me tell you: a mean prolongation of 24 msec and 11% incidence of QTc over 500 msec will make the cardiologists and intensivists pucker up. The patients were living in powder kegs and giving off sparks. "The effectiveness of HZ/AZ in treating SARS-CoV-2 infection has been demonstrated in one small human study so far2. Previously, the combination of HY/AZ resulted in mild QTc prolongation when given to young healthy volunteers8. In our work, we found that in patients with COVID-19 who were treated with HY/AZ, the QTc was significantly prolonged. This discrepancy suggests that QT prolongation may be influenced by patient attributes such as the presence of co-morbidities and the severity of the disease9. Of note, recent guidance suggested ECG screening with QTc assessment for patients with COVID-19 who are candidates for novel therapies, including HY/AZ10. In our cohort, five of nine patients with severe QTc prolongation had a normal QTc at baseline. We therefore suggest that the QTc should be followed repeatedly in patients with COVID-19 who are treated with HY/AZ, particularly in those with co-morbidities and in those who are treated with other QT-prolonging medications." I hope for the best for patients on these drugs. But don't let anyone try to convince you of their safety for Covid-19 based on old safety data in other populations.
  11. Heffernan's thread is an enlightening read that proves the veracity of this thread's title beyond a reasonable doubt.
  12. Yeah, I wish I could've let him know you can learn about the benzodiazepine receptors without keeping a supply of alprazolam tablets on hand.
  13. This seems like a good idea. I hope it works. It will almost certainly be fun to watch.
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