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Formerly DT: COVID-19 - Featuring Lots of Politics, now CR because political talk not going away


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1 minute ago, Sawbonz said:

So we are going to have 60K fewer deaths per month for the next 5 months? gtfoh

No we shouldn’t. Unless that theory is correct...or we have more outbreaks that keep pulling people forward, then we won’t know until that phenomenon ceases and we have the ridiculous lack of deaths for a few months. 
 

as an aside, I rolled my ankle tonight playing soccer with my kid, heard it pop a couple of times, and now it looks like a tennis ball. Is that a comorbidity for covid?

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8 minutes ago, Pato del Muerto said:

as an aside, I rolled my ankle tonight playing soccer with my kid, heard it pop a couple of times, and now it looks like a tennis ball. Is that a comorbidity for covid?

No but it suggests you are old and fat, both of which Would put you in the high risk category

all joking aside I know a surgeon with zero risk factors that wound up on a vent for 21 days and coded 3 separate times. One code went on for an hour. He got sick before the shutdown in March and still can’t walk a flight of stairs. Seriously fuck anyone who at this point thinks this virus is no big deal. 
 

Edit gtfoh wasn’t directed at you Pato  (unless you believe that scenario is likely). It is in general to the conspiracy theory proponents. I have been dealing with this virus for 6 months and it’s always something new with these morons

Edited by Sawbonz
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I don’t remember you posting stupid fucking bullshit over the years. You have a head injury or something recently?  

grand forks / e grand forks with a big covid spike btw. I expect Fargo/ Moorhead to be next if they haven’t already 

 

Fargos a distant 3rd behind GF and Bismarck in active cases despite having 2-3x the population ...Moorhead(MN town) would have been 3rd in ND cases until GF recently shot past them, but FM was getting hit in April and May while most of ND remained stagnant. I expect ndsu to cause an uptick but UND in GF is really making it spike. Western ND(Bismarck and west of there) is basically in fuck it mode.

 

South Dakota has been in fuck it mode since March.

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2 minutes ago, Pato del Muerto said:

It’s only a big deal for SOME people. Would be co if we could figure out which ones. 

Agreed. And until we do it would be cool if we didn’t  have to deal with “hey really only 9000 ppl died of covid dur-hur” and “it’s mostly ppl who were going to die this year anyway plus a bunch of suicides of ppl who lost their jobs derp”

I hear this type of bullshit at least once a day in clinic and I’m sick of it. I’m polite and  patient in the office but goddammit you people have brains use them 

 

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12 hours ago, Surly Bevo said:

I dunno but apparently when a dead duck asks a question he has to gtfo.

Jesus some of you are so emotional and quick on the trigger including a guy who based on his handle might actually operate on people.

Username does not check out

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New additions and recent updates:

•  China approved a Sinovac vaccine for limited use. Aug. 31

•  Russia’s Gamaleya moves into Phase 3 testing, two weeks after the vaccine received early approval. Aug. 28

•  Kazakhstan enters Phase 1. Aug. 28

•  Added a category for full approval and revised our preclinical count to include only vaccines confirmed to be in active development. Aug. 27

•  Russia’s Vector Institute enters Phase 1/2. Aug. 27

•  China’s Sichuan University begins Phase 1. Aug. 27

 

 

New additions and recent updates:

•  Convalescent plasma was approved for emergency use. Aug. 24

•  Added oleandrin, a compound produced by a toxic plant. Aug. 21

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We might be good around Christmas:

https://www.politico.com/news/2020/09/02/cdc-states-vaccine-distribution-407783


HEALTH CARE

CDC to states: Ready vaccine distribution for November
The CDC and HHS “are rapidly making preparations to implement large-scale distribution of the Covid-19 vaccines in the fall of 2020."

By SARAH OWERMOHLE

09/02/2020 03:02 PM EDT

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There was talk in I believe the College 2020 in Danger thread about the dearth of CV19 related lawsuits due to difficulty of tracing exactly where someone got CV19 etc.

I bet that will change around these vaccines that are being rushed to market. I see a spate of lawsuits coming down the pike in future years due to CV19 vaccine related stuff.

Especially if CV19 vaccines are mandated in order to go back to school or travel etc etc etc. WIll be interesting to see how this shakes out.

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I found this article that says a super computer analyzed the genome and has come up with a hypothesis that pretty much explains all the weird covid symptoms and explains why some treatments work and others don't.

https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63

 

Quote

Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.

When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a “eureka moment.” The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson’s group published their results in a paper in the journal eLife in early July.

According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms.

 

But once Covid-19 has established itself in the body, things start to get really interesting. According to Jacobson’s group, the data Summit analyzed shows that Covid-19 isn’t content to simply infect cells that already express lots of ACE2 receptors. Instead, it actively hijacks the body’s own systems, tricking it into upregulating ACE2 receptors in places where they’re usually expressed at low or medium levels, including the lungs.

In this sense, Covid-19 is like a burglar who slips in your unlocked second-floor window and starts to ransack your house. Once inside, though, they don’t just take your stuff — they also throw open all your doors and windows so their accomplices can rush in and help pillage more efficiently.

The renin–angiotensin system (RAS) controls many aspects of the circulatory system, including the body’s levels of a chemical called bradykinin, which normally helps to regulate blood pressure. According to the team’s analysis, when the virus tweaks the RAS, it causes the body’s mechanisms for regulating bradykinin to go haywire. Bradykinin receptors are resensitized, and the body also stops effectively breaking down bradykinin. (ACE normally degrades bradykinin, but when the virus downregulates it, it can’t do this as effectively.)

The end result, the researchers say, is to release a bradykinin storm — a massive, runaway buildup of bradykinin in the body. According to the bradykinin hypothesis, it’s this storm that is ultimately responsible for many of Covid-19’s deadly effects. Jacobson’s team says in their paper that “the pathology of Covid-19 is likely the result of Bradykinin Storms rather than cytokine storms,” which had been previously identified in Covid-19 patients, but that “the two may be intricately linked.” Other papers had previously identified bradykinin storms as a possible cause of Covid-19’s pathologies.

 

As bradykinin builds up in the body, it dramatically increases vascular permeability. In short, it makes your blood vessels leaky. This aligns with recent clinical data, which increasingly views Covid-19 primarily as a vascular disease, rather than a respiratory one. But Covid-19 still has a massive effect on the lungs. As blood vessels start to leak due to a bradykinin storm, the researchers say, the lungs can fill with fluid. Immune cells also leak out into the lungs, Jacobson’s team found, causing inflammation.

Coronavirus May Be a Blood Vessel Disease, Which Explains Everything

 

And Covid-19 has another especially insidious trick. Through another pathway, the team’s data shows, it increases production of hyaluronic acid (HLA) in the lungs. HLA is often used in soaps and lotions for its ability to absorb more than 1,000 times its weight in fluid. When it combines with fluid leaking into the lungs, the results are disastrous: It forms a hydrogel, which can fill the lungs in some patients. According to Jacobson, once this happens, “it’s like trying to breathe through Jell-O.”

This may explain why ventilators have proven less effective in treating advanced Covid-19 than doctors originally expected, based on experiences with other viruses. “It reaches a point where regardless of how much oxygen you pump in, it doesn’t matter, because the alveoli in the lungs are filled with this hydrogel,” Jacobson says. “The lungs become like a water balloon.” Patients can suffocate even while receiving full breathing support.

The bradykinin hypothesis also extends to many of Covid-19’s effects on the heart. About one in five hospitalized Covid-19 patients have damage to their hearts, even if they never had cardiac issues before. Some of this is likely due to the virus infecting the heart directly through its ACE2 receptors. But the RAS also controls aspects of cardiac contractions and blood pressure. According to the researchers, bradykinin storms could create arrhythmias and low blood pressure, which are often seen in Covid-19 patients.

The bradykinin hypothesis also accounts for Covid-19’s neurological effects, which are some of the most surprising and concerning elements of the disease. These symptoms (which include dizziness, seizures, delirium, and stroke) are present in as many as half of hospitalized Covid-19 patients. According to Jacobson and his team, MRI studies in France revealed that many Covid-19 patients have evidence of leaky blood vessels in their brains.

Bradykinin — especially at high doses — can also lead to a breakdown of the blood-brain barrier. Under normal circumstances, this barrier acts as a filter between your brain and the rest of your circulatory system. It lets in the nutrients and small molecules that the brain needs to function, while keeping out toxins and pathogens and keeping the brain’s internal environment tightly regulated.

If bradykinin storms cause the blood-brain barrier to break down, this could allow harmful cells and compounds into the brain, leading to inflammation, potential brain damage, and many of the neurological symptoms Covid-19 patients experience. Jacobson told me, “It is a reasonable hypothesis that many of the neurological symptoms in Covid-19 could be due to an excess of bradykinin. It has been reported that bradykinin would indeed be likely to increase the permeability of the blood-brain barrier. In addition, similar neurological symptoms have been observed in other diseases that result from an excess of bradykinin.”

Increased bradykinin levels could also account for other common Covid-19 symptoms. ACE inhibitors — a class of drugs used to treat high blood pressure — have a similar effect on the RAS system as Covid-19, increasing bradykinin levels. In fact, Jacobson and his team note in their paper that “the virus… acts pharmacologically as an ACE inhibitor” — almost directly mirroring the actions of these drugs.

 

By acting like a natural ACE inhibitor, Covid-19 may be causing the same effects that hypertensive patients sometimes get when they take blood pressure–lowering drugs. ACE inhibitors are known to cause a dry cough and fatigue, two textbook symptoms of Covid-19. And they can potentially increase blood potassium levels, which has also been observed in Covid-19 patients. The similarities between ACE inhibitor side effects and Covid-19 symptoms strengthen the bradykinin hypothesis, the researchers say.

ACE inhibitors are also known to cause a loss of taste and smell. Jacobson stresses, though, that this symptom is more likely due to the virus “affecting the cells surrounding olfactory nerve cells” than the direct effects of bradykinin.

Though still an emerging theory, the bradykinin hypothesis explains several other of Covid-19’s seemingly bizarre symptoms. Jacobson and his team speculate that leaky vasculature caused by bradykinin storms could be responsible for “Covid toes,” a condition involving swollen, bruised toes that some Covid-19 patients experience. Bradykinin can also mess with the thyroid gland, which could produce the thyroid symptoms recently observed in some patients.

The bradykinin hypothesis could also explain some of the broader demographic patterns of the disease’s spread. The researchers note that some aspects of the RAS system are sex-linked, with proteins for several receptors (such as one called TMSB4X) located on the X chromosome. This means that “women… would have twice the levels of this protein than men,” a result borne out by the researchers’ data. In their paper, Jacobson’s team concludes that this “could explain the lower incidence of Covid-19 induced mortality in women.” A genetic quirk of the RAS could be giving women extra protection against the disease.

The bradykinin hypothesis provides a model that “contributes to a better understanding of Covid-19” and “adds novelty to the existing literature,” according to scientists Frank van de Veerdonk, Jos WM van der Meer, and Roger Little, who peer-reviewed the team’s paper. It predicts nearly all the disease’s symptoms, even ones (like bruises on the toes) that at first appear random, and further suggests new treatments for the disease.

As Jacobson and team point out, several drugs target aspects of the RAS and are already FDA approved to treat other conditions. They could arguably be applied to treating Covid-19 as well. Several, like danazol, stanozolol, and ecallantide, reduce bradykinin production and could potentially stop a deadly bradykinin storm. Others, like icatibant, reduce bradykinin signaling and could blunt its effects once it’s already in the body.

Interestingly, Jacobson’s team also suggests vitamin D as a potentially useful Covid-19 drug. The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN. Again, this could stop potentially deadly bradykinin storms from forming. The researchers note that vitamin D has already been shown to help those with Covid-19. The vitamin is readily available over the counter, and around 20% of the population is deficient. If indeed the vitamin proves effective at reducing the severity of bradykinin storms, it could be an easy, relatively safe way to reduce the severity of the virus.

Other compounds could treat symptoms associated with bradykinin storms. Hymecromone, for example, could reduce hyaluronic acid levels, potentially stopping deadly hydrogels from forming in the lungs. And timbetasin could mimic the mechanism that the researchers believe protects women from more severe Covid-19 infections. All of these potential treatments are speculative, of course, and would need to be studied in a rigorous, controlled environment before their effectiveness could be determined and they could be used more broadly.

Covid-19 stands out for both the scale of its global impact and the apparent randomness of its many symptoms. Physicians have struggled to understand the disease and come up with a unified theory for how it works. Though as of yet unproven, the bradykinin hypothesis provides such a theory. And like all good hypotheses, it also provides specific, testable predictions — in this case, actual drugs that could provide relief to real patients.

The researchers are quick to point out that “the testing of any of these pharmaceutical interventions should be done in well-designed clinical trials.” As to the next step in the process, Jacobson is clear: “We have to get this message out.” His team’s finding won’t cure Covid-19. But if the treatments it points to pan out in the clinic, interventions guided by the bradykinin hypothesis could greatly reduce patients’ suffering — and potentially save lives.

WRITTEN BY

Thomas Smith

 

 

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Interesting stuff.

Two people I know who have recovered have had significant blood pressure spikes post "recovery".  Like 30 days or so later.  Both went from normal(maybe pre-hypertension) readings to over 170 systolic.  One is early 40's other is early 60's for what its worth, both male. FWIW.

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Quote
As Jacobson and team point out, several drugs target aspects of the RAS and are already FDA approved to treat other conditions. They could arguably be applied to treating Covid-19 as well. Several, like danazol, stanozolol, and ecallantide, reduce bradykinin production and could potentially stop a deadly bradykinin storm

 

 

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Edited by Surly Bevo
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2 hours ago, BrazilHorn said:

I bet that will change around these vaccines that are being rushed to market. I see a spate of lawsuits coming down the pike in future years due to CV19 vaccine related stuff.

We just think Karens are noisy now.  Wait until we rush a vaccine, and end up with a small group of people being drastically affected by it.

And lest we forget, aggy was given $265 million to help produce vaccines.

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8 hours ago, Viper said:

I found this article that says a super computer analyzed the genome and has come up with a hypothesis that pretty much explains all the weird covid symptoms and explains why some treatments work and others don't.

https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63

 

 

That's a fascinating article, but this leaves me wary about the writer

Co-Founder & CEO of Gado Images. I write, speak and consult about AI, privacy, photography, tech and the Bay Area.

He's summarizing this article 

https://elifesciences.org/articles/59177

Edited by Neonmoon
I’m dumb
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49 minutes ago, High Plains Drifter said:

Are you trying to turn me into an anti-vaxxer?

https://www.kagstv.com/article/news/local/texas-am-awarded-265-million-dollar-contract-to-prepare-covid-19-vaccine/499-e8b5b4c5-5179-4cdf-ac67-85cade79979c

Quote

Texas A&M has been awarded a 265 million dollar contract by President Trump to prepare a vaccine for COVID-19.

Nearly a decade ago, the Texas A&M University System was chosen to mass produce vaccines in the event a pandemic would strike. It was one of just three facilities in the country chosen to serve the masses.

Quote

Now with the coronavirus, the university says it’s ready to act.

“This weekend we finalized the contract with BARDA where they agreed to pay 260 million to reserve space specifically for a vaccine currently in clinical trials called Novavax," said Texas A&M University System Chancellor John Sharp.

It's got to be more simple than making ice cream, right?

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https://www.cnn.com/2020/09/03/health/penn-state-big-10-myocarditis-covid-spt-trnd/index.html
 

Quote

Up to 35 percent of Big Ten athletes who had Covid-19 now show signs of inflammation of the heart muscle, a top Penn State doctor says, reigniting the debate over the safety of playing sports during the pandemic.

Wayne Sebastianelli, Penn State's director of athletic medicine, revealed that 30 to 35 percent of the cardiac MRI scans conducted on Big Ten athletes who had contracted Covid-19 appeared to show myocarditis, an inflammation of the heart muscle. The announcement came during the State College Area Board of School Directors meeting.

 

Quote

"When we looked at our COVID-positive athletes, whether they were symptomatic or not, 30 to roughly 35 percent of their heart muscles are inflamed...and we really just don't know what to do with it right now It's still very early in the infection. Some of that has led to the Pac-12 and the Big Ten's decision to sort of put a hiatus on what's happening." Sebastianelli said.

 

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Leading causes of death:

  • Heart disease: 647,457
  • Cancer: 599,108
  • Accidents (unintentional injuries): 169,936
  • Chronic lower respiratory diseases: 160,201
  • Stroke (cerebrovascular diseases): 146,383
  • Alzheimer’s disease: 121,404
  • Diabetes: 83,564
  • Influenza and Pneumonia: 55,672
  • Nephritis, nephrotic syndrome and nephrosis: 50,633
  • Intentional self-harm (suicide): 47,173

 

Anyone have numbers or a link on the reported deaths in 2020 for these two categories above?  It sure would go a long way to prove to those moron Chinese virus unbelievers that the CDC or hospitals are not lumping it all in, seriously TIA. On a side note, some of you need to educate yourself that Covid is not the flu.  People on this thread will get mad at u bro.  

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9 hours ago, Incredulity said:

Interesting stuff.

Two people I know who have recovered have had significant blood pressure spikes post "recovery".  Like 30 days or so later.  Both went from normal(maybe pre-hypertension) readings to over 170 systolic.  One is early 40's other is early 60's for what its worth, both male. FWIW.

 

That's crazy. How did they catch the spike? Go to the doc? Or are these people who dealt with BP issues already?

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4 minutes ago, BradInATX said:

 

That's crazy. How did they catch the spike? Go to the doc? Or are these people who dealt with BP issues already?

From what I am told, the older has been donating plasma subsequent to recovery and it was caught when he went to donate.  

 

The other had been feeling lightheaded and somewhat out of breath so went back to doctor for those symptoms worried about a heart attack.

 

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I went looking for some articles this evening to see if there was any medical consensus about what the upcoming Flu season might bring (Oct - Mar).    Medical professionals have no idea, and run of the mill journalists are are all over the map.   CDC is projecting a record number of flu shots being available but has not yet started their flu-cast projections.  Some articles look at the Southern Hemisphere's just ending flu season that was historically small (almost non-existent) and predict that the social distancing we are already doing (even if we back off) will stop flu season before it starts.  Other articles that seem to be from stupid-ass places that get really cold predict that 'indoor season' is going to make the flu spike.    If you live in a place that has an 'indoor season', you should move.

 

  

Edited by 0xdeadbeef
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3 minutes ago, Viper said:

that's interesting. Eric Nahlin said yesterday that they've been testing our players for this and none of them have it.

Interesting indeed.

"Additionally, some have inferred his comments may have related directly to Penn State student athletes. At this time, there have been no cases of myocarditis in COVID-19 positive student-athletes at Penn State."

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3 minutes ago, Captainant said:

Well it's not like the summer was supposed to completely knock out COVID like a miracle, right?

It's too early to put down a number, but it's not outrageous to expect higher numbers of cases and deaths during the actual flu season

if its 1000 a day plus a bump to 2000 a day for 2 of the 4 months you could get there but who knows.

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1 hour ago, MNLonghornFUKM said:


I’d believe it more if every place that’s been an epicenter hasn’t seen the same slope that resembles one another

It must be nice just to go around saying whatever bullshit you feel like saying without ever considering whether or not it's factual or true. It gives you a certain amount of freedom that a lot of people don't enjoy.

Australia

australia.JPG.e132631009965e15d5cd3b4e2b0fe164.JPG

 

Spain

spain.JPG.9d83a6b989d4be436a1d47a37063f016.JPG

 

France

france.JPG.6104cf2d9dcfd72e485d3067a8ffe983.JPG

Edited by BradInATX
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It must be nice just to go around saying whatever bullshit you feel like saying without ever considering whether or not it's factual or true. It gives you a certain amount of freedom that a lot of people don't enjoy.
Australia
australia.JPG.e132631009965e15d5cd3b4e2b0fe164.JPG
 
Spain
spain.JPG.9d83a6b989d4be436a1d47a37063f016.JPG
 
France
france.JPG.6104cf2d9dcfd72e485d3067a8ffe983.JPG

Holy shit. Are those states?

43d088201dfa32e6124e13925b52b886.plist
7844869eb0b39cb52c12cc31950d7032.plist
dc19b94c3f137d049d619f96e6440b1a.plist
2d8e8cd89fba3a3257c1356ba757f2b9.plist
1fcd99f6fe45fd025b7e4766caffb8d9.plist
b1dbaf3b626282a09c276e2db6d923d2.plist
a495898272f9f2487ba1e500d8c6b479.plist



And The Godfather

ffdc1e87acdcd6e1e43df73d44334d34.jpg


Yea I have no idea why you think whatever happens in Australia, France and Spain has to do with America.


Australia’s gone crazy from what I’ve seen in terms of lock down.
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22 minutes ago, Incredulity said:

Well, as I sit here on a Friday watching the third broadcast week of high school football I must again ask, wtf are we doing?

Are FL, OH, OK, , KY.,.. football players getting sick??? Dropping dead??

they are going to at Penn State.  30% of their athletes have mayocarditis due to covid.

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  • hayden_horn changed the title to Formerly DT: COVID-19 - Featuring Lots of Politics, now CR because political talk not going away


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