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Txzen

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Everything posted by Txzen

  1. Pretty easy to get outside on us. Not good.
  2. Stubbornly running between the tackles with this line seems futile.
  3. Em, it’s where the ball is, not your feet. Why are our punt returners confused about that?
  4. NIH whistleblower at the NIH fired by RFK. Her complaint is pretty awful, specifically with the interactions with the newly appointed head - Memoli - and James McElroy his chief of staff, serving as a liaison to the White House. tl;dr We are proper fucked.
  5. His game is as strong as his mustache.
  6. Fucking hell, RFK suggesting that they can have a vaccine for 'the whole phylum of viruses' isn't clumsy, it's yet another example of his utter lack of basic high school level science comprehension. It's like hearing that someone is working on a cancer treatment for brain cancer and saying it can be used against all cancers. Par for the course with this group. Ok, so what's this about a universal vaccine? The current effort is specifically targeting influenza. Science background: Because of the challenges in making these vaccines for seasonal and pandemic influenza strains, there's been a large ongoing effort to make a 'universal' vaccine for all these variants, as well as making a better vaccine to improve the durability, efficacy and breadth of protection. This is yet another global effort best encompassed by this chart which shows the multitude of world-wide scientific approaches using virus-based, nucleic-acid (mRNA) based, nanoparticles, recombinant proteins, virus-like particles and alternative viral methods - at this moment, based on this tracker, 225 candidates, 30 active trials, 188 developers and those six different platforms. There is considerable confusion around RFK's announcement regarding the nomination of the specific approach he endorsed. First, it's not new as the Phase 1 for this approach was put forward by the NIH in a Phase 1, announced by Fauci He Who Shall Not Be Named, in 2022. The specific vaccine (BPL-1357) uses a whole virus which has been inactivated by a chemical (beta-propiolactone or BPL) to eliminate the infectivity while maintaining the structural integrity of the virus particle so it can be used in a vaccine. It's manufactured in canine kidney cells rather than chicken eggs. Second, the approach with BPL-1357 contains Influenza type A, but not the Influenza type B (which is a component of current influenza vaccines), which seems to defeat the purpose of a 'universal' approach. The use of inactivated viruses is vaccine production is one of the earliest approaches ever developed, which produced the first vaccines in the late 1800s for thyphoid, cholera and the first polio vaccines in the '50s. But frankly, it's an older technology and many of those listed in the above chart utilize more cutting edge methods. Finally, this nomination of this one method out of all the other potential approaches (dubbed 'Generation Gold Standard') puts a large amount of money ($500m) in this one approach, developed by Dr. Matthew Memoli...who was recently names as the principal director of the NIH. So, tl;dr - a lot of eggs (kidneys?) in one basket. There's nothing wrong, per se, with a whole inactivated virus vaccine but it's not a new approach, the vaccine touted from RFK is far from universal, it ignores many other ways to build a better mousetrap, and puts a shit ton of funding in the lab of one guy who happens to have been nominated to run the place.
  7. There's so much misunderstanding here. The STING pathway is an essential mechanism your immune system responds to infection. It's not a 'cancer activating pathway'. SV40 is a virus which infects primates. When we want to drive expression of a gene from an engineered plasmid, one needs a robust promoter which attracts the cellular machinery to transcribe the gene. The reference discusses the SV40 promoter/enhancer...but there is no interaction with p53. With the native SV40 virus, one of the viral protections is the T antigen, which interacts with p53 to enable the virus to transform the cell. There is no T antigen in the vaccine production, that's absurd. Much like the mention of the pcDNA3.1 plasmid referenced in the paper - that uses a CMV promoter to drive whatever gene(s) you put in it...but this does not make the cytomegalovirus.
  8. Yes, but so were we.
  9. I put on my robe and wizard hat.
  10. Bout damn time.
  11. Is he also saying there’s an epidemic of bad tackling?
  12. Look, I know this is is SHSU, but this is the way I would expect our QB to perform. OL needs more snaps and kumbaya.
  13. Dogs and cats living together, mass hysteria!
  14. Let’s hope he keeps it. Totally different play from him today.
  15. Do we have other options for kick returner?
  16. ESPN on Roku working just fine, surprisingly.
  17. Or 10 yards behind him.
  18. I like this Arch.
  19. Oh Auburn.
  20. Is that worse than what we have now?
  21. Txzen

    A&M at ND

    Cal vs Minn is spicy, yo.
  22. Txzen

    A&M at ND

    For both our sakes I hope it happens soon…
  23. Enough with the comparisons to VY and how there were call for him to move to WR early in his time. Arch doesn’t have the hands to be a WR.
  24. This. I expected the late cross-body throws over the middle for INTs. But from a clean pocket, the high, behind, and off the turf throws - no. To coin a phrase - he is very self-defecating.
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