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Dontshootrude

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Posts posted by Dontshootrude

  1. 10 hours ago, C-Man said:

    Parchment paper seems like a bad idea in the Ooni. I used it all the time on the Egg. But my pizzas on the Egg weren't very good.

    Semolina works like a fucking charm. Tried the screen tonight on some leftover dough tonight. Worked ok, I guess, but if I can continue to get the results from NYE without it and cooking right on the stone, I don't see any reason to change. Bear in mind, I'm cooking the 12-inch pies on my Ooni 16 at this time. I think the screen might make more sense on a bigger pie.

    Agree with this.  I use semolina in my ooni and it comes out great.  Parchment paper use less than ideal in an ooni where your pizza cooks in a minute.

  2. 2 minutes ago, Surly Bevo said:

    So is this basically saying it will infect you easily, particularly in nose, throat etc but doesn't really do well in lung cells/tissue....particularly if you have some acquired immunity through vax.  

    Exactly. It's good news. The evidence is becoming substantial that this is a milder version.

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  3. 20 minutes ago, Surly Bevo said:

    Why do you all need tests?  I mean you have a low grade on and off fever, generally feel bad but not too bad, get over it in a few days without getting much worse.  What's the allure of the test?  If it drags on for more than 3 or 4 days, symptoms don't improve, fever stays, things gets worse etc by all means have at it.  Just not sure why anybody would subject themselves when feeling mildly or even moderately under the weather a bit to a goose chase/long wait time.

    Knowing for sure that you had it is good information for your decision making going forward.  There is going to be a lot of studies on when you will need a booster under different circumstances, and it is certainly possible that a breakthrough case will provide more durable immunity than vaccination alone.

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  4. In regards to vaccinated individuals being able to transmit COVID-19 compared to unvaccinated (naive), the evidence still suggests an unvaccinated person is more likely to spread it compared to a vaccinated person.  Viral load is going to be similar for a period of time in both people, but a vaccinated person is more likely to shed virus for a shorter period of time, and the virus they shed is going to be less likely to be infectious.  If the virus particles are covered in antibodies, they won't be able to infect new cells.  

    https://www.medrxiv.org/content/10.1101/2021.07.28.21261295v1

    https://www.medrxiv.org/content/10.1101/2021.08.20.21262158v1

    https://www.medrxiv.org/content/10.1101/2021.08.30.21262701v1

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  5. 40 minutes ago, GTX Horn said:

    Do the boosters take 2-3 weeks to reach full efficacy like the original 2 shots did or is the effect more immediate because of prior immune responses to the first 2 shots?

    Data out of UK suggests it takes 2 weeks for a booster to reach full effectiveness.

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  6. 4 minutes ago, Surly Bevo said:

    Sooo if I got a Moderna "booster" at the very end of September and before I believe it was the authorized half-dose I got double the same stuff or is the booster a different formulation (I know it is half dose of a vaccine jab)

    The formulation is the same in the booster and original shot.

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  7. On 12/18/2021 at 3:14 PM, Surly Bevo said:

    So question.  At this point rather than continue pounding away resources at making an "original" version of  the vaccine work for 2-5 year olds that so far have seemed very very low risk outcome wise would it not make more sense for the Pfizers and Modernas of the world to be figuring out how to make some form of a trivalent, quadrivalent? vaccine/booster.  Is that even possible?  Just seems like they would do something like isolate the Alpha, Delta, Omicron and say one other spike that has been drifting around out there and create m-RNA that would get your cells pumping out all three varieties?  I'm sure it's more complicated than I just made it sound, or is it?  

    Moderna released a press release addressing this just today.

    https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Preliminary-Booster-Data-and-Updates-Strategy-to-Address-Omicron-Variant/default.aspx

    A couple of interesting tidbits in there:

    Quote

    Authorized booster (50 µg of mRNA-1273) increases Omicron neutralizing antibody levels approximately 37-fold; a 100 µg booster dose of mRNA-1273 increases Omicron neutralizing antibody levels approximately 83-fold

    And related to your question:

    Quote

    The multivalent candidates boosted Omicron specific neutralizing antibody levels to similarly high levels at both the 50 µg and 100 µg levels.

    Keep in mind the multivalent candidates contained prior variants and not omicron.  Our immune system really is amazing, isn't it?

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  8. 11 hours ago, SDG said:

    Posting here seems appropriate 

     

    Long suffering Georgia Tech fan here.  As much of a dumpster fire the last three years have been, Coach Choice was one of the few bright spots.  He was by far our best recruiter and the only position group that seemed to make any progress was RB.  He was instrumental in landing Jahmyr Gibbs who was our most highly rated recruit since Calvin Johnson. He, by the way, is in the transfer portal and it wouldn't surprise me to see Choice try to bring him to Texas.  You all landed a good one.

    Our hope as GT fans is he gains experience at big time programs for the next several years and returns to GT as an OC or head coach one day.  He is that well regarded among the fanbase.

     

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  9. 13 minutes ago, DDD Dad said:


    You should definitely take the medical advice of an anonymous poster on a football message board.

    Citation: https://jamanetwork.com/journals/jama/fullarticle/2787447

     

    Summary: you get a very robust immune response after a breakthrough infection, perhaps as good as the hybrid immunity we see after a recovered individual gets vaccinated.  And on top of that, there is a substantial increase in the class of antibodies (IgA) expressed on mucus membranes (like in your nose and respiratory tract) that is markedly better than what is achieved through vaccination that should do a better job at preventing infection.

    This is pretty basic immunology.

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  10. 14 hours ago, Marcusshelton said:

    Fully vaccinated in April (Moderna). Tested positive late October/early November. One day of fever and generally feeling shitty (like after second shot). Then lost taste and smell for like a week. Was going to get booster over holidays, but not sure now. 

    I wouldn't get the booster.  Your infection served as the booster.

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  11. 8 hours ago, ChuckNorrisActionJeans said:

    This may be a dumb question. My spouse got the J&J gimp shot in March. Got a Moderna booster 6-8 weeks ago. 

    Is there any synergistic effect with the J&J and Mrna booster, or is it just like you get the shit protection from J&J and then you're basically partially vaxxed with Moderna?

    I haven't found anything official that recommends J&J people get 2 shots of mrna to boost. Does she need another shot, esp. bc Omicron? 

    The single shot she got from Moderna should have provided her with a substantial boost and will bring her up to roughly the same level of protection as someone who had 3 mRNA shots.  And I'm only talking about antibody response here.....her T cell immunity might be preferable, but we don't have solid data to know this for sure right now.  

    boostershotchoice.thumb.png.763028405502815b9eed2f27ba8a1481.png

    Source

  12. 1 hour ago, berlinerbaer said:

    Random immunology questions... Can someone explain why people are fretting so much about antibody levels when the B cells responsible for making them last the rest of your life? Is the concern that low initial levels during infection would allow the virus to gain a foothold before antibody levels rebound? Can the virus suppress antibody production?

    Your antibody level will determine how likely you are to become infected and also, to a lesser extent, how likely you are to have a severe case.  Keep in mind you need a lot more antibodies to prevent infection than you do to prevent severe disease.  Unfortunately we now know protection against infection is short lived after vaccination (a couple of months) whence why people are concerned about the numbers.  However, protection against severe disease and death are certainly going to last significantly longer and I think this protection is being undersold.   

    The question is how long the B cells (and don't forget T cells!) will last to protect against severe disease.  They certainly will last more than a year, but we don't know if there will be appreciable numbers at 5, 10, 20 years or longer to protect against severe disease.  That's why some vaccines require regular boosters (like the Tdap that is given every ten years or after exposure) to replenish the B cell and T cell populations that normally die off.  It is too early to say what time periods COVID vaccines will be necessary going forward, and what the vaccination schedule will look like for optimal results.  I wouldn't be surprised if we see recommendations that mix different vaccine technologies like adenovirus vector (J&J), mRNA (Pfizer, Moderna), subunit (Novavax) and perhaps other technologies that are currently being explored (DNA vaccines, for example) and hammer down scheduling when the shots should be given.  We are a long way away from knowing what the optimal solution is here, and we are years, perhaps decades away from fully understanding it unfortunately.    

    On 12/16/2021 at 11:51 PM, Anastasis said:

    Click through to the thread for interpretation...

     

    Affinity maturation doing work.

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  13. 13 minutes ago, Bevo said:

    Didn't you post an article awhile back on the subject? I think it was when you first started posting on COVID.

     

    The vaccines are not directly responsible for the mutations occurring in SAS-CoV-2, the virus that causes COVID-19. 

    Viruses mutate at a predictable frequency. We use that predictable mutation rate to determine where a virus came from, and how long ago it emerged. 

    The ability of the SARs-CoV-2 virus to mutate and create new variants is mostly dependent on the amount of virus replicating. In other words, when there are more people infected with the virus that causes COVID-19, there is more possibility for mutations to occur and new variants to arise. 

    The timeline for this claim also doesn't add up. The most problematic variant we've dealt with so far, the delta variant, was first isolated in October 2020 in India, from a sample collected in September 2020. India didn't begin a public vaccination campaign until Jan. 16, 2021. 

    Below I've outlined all the variants of concern currently in the U.S., along with their country of origin, earliest sample date and when public vaccination began in each country. 

    Alpha

    • Location first detected: United Kingdom
    • Earliest sample date: Sept. 3, 2020
    • The U.K.'s vaccination efforts began Dec. 8, 2020

    Beta

    • Location first detected: South Africa
    • Earliest sample date: Sept. 1, 2020
    • South Africa's vaccination efforts began Feb. 17, 2021

    Gamma

    • Location first detected: Brazil
    • Earliest sample date: Oct. 1, 2020
    • Brazil's vaccination efforts began Jan. 18, 2021

    Delta

    • Location first detected: India
    • Earliest sample date: Sept. 22, 2020
    • India's vaccination efforts began Jan. 16, 2021

    As you can see, all of the mutations we're currently dealing with emerged well before the COVID-19 vaccines were publicly available. Learn more about the variants of concern in the U.S. 

    Vaccinating a large portion of the population will reduce the overall number of infections. Reducing the number of infections reduces the opportunities the virus has to mutate into new variants

    Getting vaccinated, and encouraging your loved ones to get vaccinated, is the best way to prevent more dangerous future mutations. 

    https://www.nebraskamed.com/COVID/are-leaky-vaccines-causing-the-new-covid-19-mutations

     

    Probably? It is hard to keep track.  There have been a few interesting manuscripts on the subject.  This one comes to mind where they saw COVID evolution in a single immunocompromised patient receiving convalescent plasma treatment:

    https://www.nature.com/articles/s41586-021-03291-y

  14. 1 hour ago, RollLeft said:

    Moderna vaxxed x2 

    Last Friday i was on a flight with a dude coughing his lungs out...(My gut tells me it was his inconsiderate ass)

    This past Wednesday i had symptoms of what I thought was a cold...

    Thursday had a terrible cough...fever wanted to hit but never did, i felt my body fight it off...

    Friday a bit of daria(sic) and lost sense of smell....

    Today i tested positive...I took 5000u/i of vitamin D and shit ton of C and few of zinc...I'm drinking plenty of water

    What else do you opinionated assholes know that i should do....thanks i'll hang up and listen.

    If you are in a higher risk category you can try to get a monoclonal antibody infusion, but if you are healthy you should clear the infection in a couple of days thanks to your prior vaccination.  

  15. On 12/17/2021 at 4:10 PM, burdine said:

    Mutations can occur in vaxxed of course  HOWEVER

    the more the virus spreads and the longer it persists in an individual likely increases the opportunity for mutation.

    Thus, a vaxxed population should slow the rate of mutation down considerably but not completely.

    Not much about covid is black and white.

    This is correct.  The thought is a lot of these variants are coming from unvaxxed immunocompromised individuals that have persistent long lasting infections.  This allows the virus to have a huge number of replication cycles thus increasing the odds a random mutation will occur which leads to a competitive benefit.  

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  16. 25 minutes ago, G650 said:

    Dollar per content is worse than other services, and I have been in a battle with them for over 2 years trying to cancel them.

    I just updated my saved credit card with one from my Privacy account and set the spend limit to $1.  So fuck them they won't be scamming me too.  Thanks for the heads up.

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  17. 7 minutes ago, G650 said:

    Dollar per content is worse than other services, and I have been in a battle with them for over 2 years trying to cancel them.

    Oh shit.  Well that doesn't bode well.  I'll definitely be cancelling before the free trial period is over.

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