Jump to content

Heme Doc

Full Members
  • Posts

    173
  • Joined

  • Last visited

Posts posted by Heme Doc

  1. 7 hours ago, shakahorn said:

    Just got the Pfizer shot - first one.  Bro-in-law is an MD at a small local hospital and because so many slapdick employees are refusing the vaccine, they have extra supply they need to get rid of.  Need to go back on 1/13 for shot 2. The nurse who popped me told me to avoid alcohol for a week.  When I gave her the "it's 12/23" eyeroll she just smiled and said that wasn't a hard and fast rule.

    Or maybe, “it’s not a rule at all about alcohol and I’m just making shit up”.  Glad you were able to get a vaccine.  Fuck the slapdick asshole employees refusing vaccine.  

    • Fuck Around and Find Out 1
  2. 29 minutes ago, Brisketexan said:

    Quoting because good post.  I think you're likely right, but this remains the right path.

    It was the Moderna data

    Everyone got swabbed when they came back for their second shot.

    At that time, there were 14 asymptomatic infections in the vaccine group and 38 in the placebo group.  That’s very encouraging, (an almost 3x reduction), especially since patients only had one dose at that check.  
     

    I haven’t seen Pfizer data on this, but can confirm from personal experience that they did nasal swabs with both first and second vaccine injections.  Hopefully that data will be just as good. 

  3. 6 hours ago, Pato del Muerto said:

    The same people on my social media that have been saying don’t live scared of a virus with a “99.95% survival rate” for the past 8 months are now the same ones saying they won’t get the vaccine. 
     

    it’s all I can do to not engage their idiocy. Damn it’s frustrating. 

    I wonder if those same fearless morons got the flu vaccine, MMR, polio, HepB, HPV, or varicella vaccines?  If they did, were they worried about dying from any of those?

    • Hook 'Em 1
  4. 21 hours ago, Newdoc said:

    The incidence of Bell’s palsy was about on par with the population in general that was not in the trial. It just so happened that the people receiving placebo didn’t have any incidental cases.

    Fuck that Sooner Blake Bell and his damn palsy!

  5. 53 minutes ago, Pimphand said:

    And yet why have none of those vaccines ever seen the light of day?  Antibody immune enhancement has happened in *all* of the challenge studies.

    So yes the outcomes are known you will not be harmed by it and your body will have robust antibody production only one of the next several covid mutations is probably going to come be your grim reaper.  Have fun with that I ain't playing that game I'll rock on with my existing immune system and if it fails me then it was my time to go.

    frustrated billy madison GIF

    • Hook 'Em 2
  6. 27 minutes ago, DaysOff said:


    How do these people work in medicine? This technology has been worked on for ten years going back to SARS. The only part that was compressed was running stage trials in parallel. Major side effects would show within two months and we're past that for most participants. The vaccine is flushed from your body in weeks only leaving the immune response. Playing cards with my sister's kids.

    THIS!

    I guess I didn’t realize how many cowards and dumbasses we have out there.

    My hospital system not requiring it.  But everyone I know is getting it and wants it.  Maybe because our hospital is up to it’s eyeballs with COVID.  

    • Hook 'Em 1
  7. 12 minutes ago, Pato del Muerto said:

    That our natural immunoresponse is to the N as you say, could mutations there be the reason people can or have had second infection?  Whereas the spike is a stable piece by replication necessity and thus antibodies for it continue to be useful?

    Our natural immune response is against all parts of the coronavirus (Nucleocapsid, Spike protein, etc).  It’s just that what we are testing for primarily right now is antibodies against N.  So we have a way to distinguish immunity through vaccination (should only have antibodies to Spike) vs immunity through infection (should have antibodies to N, Spike, etc)
     

    I’m not sure why people get infected twice, but that is very rare.  Fortunately, coronaviruses are more stable than other viruses like flu, so hopefully we won’t see emergence of mutations affecting Spike protein that will allow it to evade immunity.  

     

     

  8. Two more interesting vaccine things...

    It would be nice if we had a quick, readily available test for COVID neutralizing antibodies.  Probably around 60M Americans have already been infected with COVID.  So if you could identify those people, their vaccination could be deferred since it will be in somewhat short supply initially.

    Which transitions to the second thing...Almost all of our commercially available antibody tests are to the N (nucleocapsid) part of the coronavirus.  But these vaccines are all built to elicit antibodies to the S (spike) part of the virus.     So if I get vaccine, my antibody test will be negative for N (assuming I haven’t actually had COVID).  So what Pfizer is doing is checking vaccinated folks for the presence N antibodies, which could only be elicited by actual COVID infection.  So you’ll have your answer if vaccination prevents infection entirely (thus halting transmission) or if it only causes infections to be asymptomatic.  

    • Hook 'Em 4
    • Like 2
  9. Happy EUA Day for Pfizer vaccine!  If we don’t see the FDA issue an EUA today, they should be lit on fire.  Also, who were the four “no” votes on the committee?  I’d like to kick them in the balls repeatedly.  

    I got an email from my Pfizer trial location basically letting me know that I’d be unblinded once the EUA was issued and if I received placebo (unlikely), then they’d get me in ASAP for the real vaccine because I’m in healthcare.  
     

    • Hook 'Em 1
  10. On 12/7/2020 at 5:32 PM, Bevo said:

    I heard some not so great news so I hope your information is more accurate. My GP's office is pretty large and has a good sized lab with Quest on the premises. I asked to speak with a PA today and the PA told me that they haven't been told the exact date that they will be receiving the vaccine and no one has been trained on it and they don't have any sort of a list on who to give the vaccine. And the PA had no clue when she was going to be able to get the vaccine herself. So, based on that, at least at their facility, there is no way that they will be able to administer it in a week.

    Then I called my dad (I was still commuting home) and told him the story and he was told by the Chief of CV Med at UT that they wouldn't be administering it to MDs until mid-January. I asked him about Methodist and St. Luke's and he said that he hadn't spoken to anyone there. I assume you are at MD Anderson. Are y'all really getting it on the 14th? Just curious what you are hearing and when you can get vaccinated.

    I think initial doses will go to larger hospital systems and will be available next week.  I’m not at MDA, but I know they’re getting doses.  I think next week hospital employees taking care of COVID patients will start getting vaccinated.

    Here’s a link to the Texas plan (not sure if already posted)

    https://www.dshs.texas.gov/news/updates.shtm#Vaccine

    And a link to week 1 vaccine allocation numbers

    https://www.dshs.texas.gov/news/updates/COVIDVaccineAllocation-Week1.pdf
     

    It’s not clear when exactly outpatient offices will begin getting doses, but I’d guess later in December or January at latest.  
     

    I guess the Chief of CV med was uninformed.  

  11. I think it becomes endemic.  But let’s at least get shit under control before we talk about eradication.  

    I think protective immunity will last at least a year.  Antibody levels may decline to a point where you are susceptible and need a booster.  But even if your antibodies wane and you get it, your disease will likely be mild or asymptomatic because your body already knows how to mount an immune response against it (thanks memory B cells and T cells!) so you’ll ramp up antibody production very quickly before it can cause as much trouble

    My hospital (2nd largest in large Texas city) says they will have vaccine Dec 14 and be off to the races.  

    • Hook 'Em 2
    • Like 1
  12. 10 minutes ago, Beantown Express 2.0 said:

    So will we have a choice of which vaccine to get or will it just be based on what my local pharmacy gets in stock (assuming they only get a vaccine from one company and not all 3)?

    You probably won’t get to choose.  But the first 2 that will be approved (Moderna and Pfizer) have little to any difference in terms of efficacy, type of vaccine (mRNA), or side effect profile

  13. 8 hours ago, Brisketexan said:

    So, I’ve been refining my math. Hadn’t thought about the fact that young kids will be in the last group to get the vaccine. Around 40 million people here are under 10, out of a population of 330 million. So, around 290 million in the pool to get vaccines in the near term.

    Presume that 20% of that group will be resistant/apathetic, which takes the near term “to be vaccinated” group down to around 230 million.

    (Here’s where my numbers may be off, because I’m not sure if it’s just for the Pfizer vaccine or all three). I saw that Pfizer estimated that they’d administer 20 million doses this year, then 30 million a month after that. If that’s just the Pfizer vaccine, that’s great, as we could have additional doses of others in the same timeframe? Anyway, by the end of June, we’d hit 200 million, and the 230 million by the end of July.

    That’s pretty good. Hopeful, even. And if there are even more doses available of other options, it could happen even faster - does anyone know the story there?

    Even though I was told there would be no math, I think your numbers/timeframe are quite realistic, which is why I too am hopeful.  

  14. 6 hours ago, troph said:

    How long do we expect immunity to last? MMR is years, flu is less than a year, what is this one expected to be? 

    I don’t think we know the exact answer to that yet, but recent data suggests “years” for most folks.  I linked a nice twitter feed and recent article below that explain it a bit more.  
     

    https://www.medrxiv.org/content/10.1101/2020.11.18.20234369v1

     

    https://mobile.twitter.com/apoorva_nyc/status/1328751557719040001

     

    • Hook 'Em 1
    • Like 1
  15. 7 hours ago, sunset87 said:

    A question for the docs. I have had Bell’s Palsy 3 times, the last case was about 5 years ago and the last two cases were mild. I got both of the Shingrix vaccines this past year, and had pretty strong reactions to both. Felt like the flu for a couple of days.

    Is that because my immune system’s response was very aggressive since it had already fought Bell’s Palsy (both are herpes zoster viruses) several times?

    I’ve never had any reaction to the flu shot. Just curious if I should expect a really strong reaction to a COVID vaccine, which I will get. Or if my previous experiences don’t mean anything about how I will react to a COVID vax.

    With Moderna/Pfizer vaccines, I’d expect a reaction for 1-2 days of headache, fatigue, maybe fever/chills and some body aches after the 2nd dose especially.  Take some Tylenol and ibuprofen and be happy that your immune system is doing its job and you’re helping to kick this things ass.  Those flu-like reactions are pretty common after Shingrix and I don’t think that reaction or the Bell’s palsy can reliably predict how you’ll react to a COVID vaccine.  I know about 10 people on the Pfizer trial.  The 5 of us who got vaccine all had some side effects, usually after the 2nd dose but nothing too severe and that a little Tylenol couldn’t take care of

    • Hook 'Em 1
×
×
  • Create New...