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Heme Doc

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Posts posted by Heme Doc

  1. 19 minutes ago, Xian said:

    God dammit. I wasn't worried at all until reading this shit. Hell, i was planning on waiting in line the first day i was able. 
     

    should i be worried?  I don't want to be riddled with cancer due to shit 40 years from now. 

    You shouldn’t be worried.  

    • Hook 'Em 1
  2. 16 minutes ago, Newdoc said:

    Not me. The guy’s a scientist first and foremost and respected at that. He’s not a good PR person especially off the cuff. He makes scientific statements sometimes without qualifications that a vast majority of Americans cannot process and he would end up scaring the shit out of half the country.

    Good point

  3. 15 minutes ago, Hagbard Celine said:

    astrazeneca/oxford nanotech.

    yes or no.

    See reply to Bevo above.

    But one interesting difference in the AZ/Oxford trial compared to Moderna and Pfizer trials is that in AZ/Oxford they actually did weekly nasal swabs in all participants (as opposed to only testing with PCR if participants had symptoms).  And they found that the vaccinees had lower rates of asymptomatic infection, suggesting that the vaccine could stop transmission/block infection entirely (not just make you infected but asymptomatic).  Moderna/Pfizer vaccines may do the same thing, but we don’t know that.  I can’t wait to see this data, as we won’t have anything like this for Pfizer/Moderna.  

     

     

  4. 40 minutes ago, Armybrat said:

    How come doctors using all them bigass medical nerd words have such horrible penmanship?

    Because we can’t spell for shit so it’s just a way to cover that we know how to say them but you’ll never know we can’t spell them

    • Like 1
    • Haha 1
  5. 23 minutes ago, Bevo said:

    I know you specialize in leukemia and lymphoma, and you aren't worried, and adenovirus is epichromosal, but I'm more worried about long-term effects from adenovirus products. mRNA or recombinant proteins for me. 

    I tend to be more nervous about adenoviral vaccines than mRNA vaccines also.  Fortunately, it seems serious side effects with each have been quite rare.  I believe that the AstraZeneca trial (adenovirus vector) was halted because of a case of transverse myelitis a few months ago.  I don’t believe Pfizer or Moderna saw any issues like that.   But if a serious side effect (say Guillan Barre) only occurs in 1:500,000 patients, then a clinical trial of 40,000 people might not pick it up.  But you’ll damn sure see it once you start vaccinating millions of people.  Hell, we still see cases of Guillan Barre each year with the flu vaccine.  

    Each person will need to make their own calculated decision about their risk of getting COVID and falling seriously ill or dying vs risks of the vaccine.  From my look at the data, getting the vaccine (any of them) would be of significantly less risk for most.  

    I’m hopeful that messaging from the new Biden administration and other mouthpieces in the government/medical community can clearly communicate to the public about some of these issues related to COVID vaccines including their effectiveness, safety, and expected side effects. I’d love to see Fauci go on 60 Minutes and lay out this stuff in an interview and at the end stand up and take the vaccine on TV.  

    • Like 1
  6. 2 hours ago, Anastasis said:

    He's referring to your body mounting an immune response to the viral vaccine vector, in this case an adenovirus. The vector vaccines use a virus as the vector to deliver the genes coding for the spike protein to your cells.  Your body will try to mount an immune response to the vector. The lower response rate with the higher first dose may suggest that a lower first dose followed by the higher second dose is less likely to stimulate the immune response to the vector.  

     

    I personally will line up day 1 my number comes up for an MRNA based vax.  Not as comfortable with the vector vaccines until more data come out.  Haven't decided what we are going to do with the kiddos (5-11) yet. 

    Top notch description of “vector immunity”

    I tell everyone that the only thing I’ve noticed since getting the Pfizer vaccine is that my cock is huge (average size for Surl).  I don’t mention that it was like that pre-vaccine.  

    • Hook 'Em 1
  7. 2 hours ago, Brisketexan said:

    If there's anything I hate, it's abbreviation of the duration of transgene expression.

    Well, that, and the Dutch.  I also hate the Dutch.

    Similarly, there’s only two things that scare me.  The risk of transverse myelitis or Guillan Barre after vaccination with an adenovirus vector.  

    That, and carnies.  Small hands.  Smell like cabbage.

    • Hook 'Em 3
  8. https://www.cnbc.com/amp/2020/11/23/oxford-astrazeneca-covid-vaccine-is-70percent-effective-trial-shows-.html?__twitter_impression=true
     

    Mondays are vaccine efficacy announcement days, it seems.

    More good news from AstraZeneca.  90% efficacy in large phase 3 trial in group getting half dose vaccine followed by full dose one month later.  Interestingly, the group that got two full doses of vaccine one month apart only was 62% efficacious.  This is probably due to vector immunity.  The delivery method for this vaccine is an Adenovirus, so  some people probably mount more response to that and not Spike protein.  

    Another benefit of this vaccine is that it can be stored in regular refrigeration temperatures.  

    Starting to see the light at the end of the tunnel.  Not sure exactly how long the tunnel is, but there’s light at the end.
     

     

    • Hook 'Em 1
  9. 21 minutes ago, NorthLoop said:

    I like this Heme Doc guy. 

    Can we have him battle it out with ChiTownDoc? I mean I like ChiTown.. but he is a sooner fuck. But then again he does love clowining Trump dumbasses on the reg. 

    I like ChiTownDoc and wish to subscribe to his newsletter.  I too enjoy clowning Trump dumbfucks.  

    • Hook 'Em 2
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  10. 4 minutes ago, bschoolprof said:

    I'm pro-vaccine, obviously, but the fact that mRNA vaccines are brand new (they've never been given before) and we have no evidence on their long term safety, I'm a bit nervous.  I know the whitecoats tell me that, theoretically, the long run risks are small because the mRNA breaks down quickly, and efficacy is the real concern. However, jiggering around with our cells to produce virus spikes they weren't designed to produce gives me the heeby jeebies.  What could possibly go wrong?  

    Anyway, I expect this will be the next great politicized nonsense that further tears away at the national fabric.  Personally, I'd rather wait for the traditional vaccines that are in the works. 

    If I'm 80+ though, sign me up now bitches.  

    I totally get that perspective especially if you are younger and healthy.  You’ll have some time to wait for more folks ahead of you in line to get the vaccine to make sure there aren’t any concerning safety signals.  Plus, there will likely be more traditional vaccine types (inactivated/attenuated virus) come to market in 2021.  The rare and more severe vaccine side effects like transverse myelitis or Guillan Barre usually occur pretty quickly after vaccination and haven’t been seen with these mRNA constructs.  One very reassuring thing about the fantastic efficacy of the Moderna and Pfizer vaccines (both on par with HepB and MMR vaccines) is that is bodes very well for success of other vaccines that will be coming down the pipeline.

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  11. 9 hours ago, Lobo said:

    With the latest mid-week death tolls, the United States officially surpassed every last "shithole country" in terms of Covid-19 deaths per 1mm citizens.  

    But we are still doing better than Morocco.  Which will likely be declared a "shithole country" by month's end.  

    Any news on blood type correlation to viral defeat?  

    Here’s the data best I know about looking at this question.  From the Annals of Hematology in July

    Bottom Line...”Blood type was not associated with risk of intubation or death in patients with COVID-19. Patients with blood types B and AB who received a test were more likely to test positive and blood type O was less likely to test positive. Rh+ patients were more likely to test positive.”

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354354/

  12. 43 minutes ago, Anastasis said:

    Some of the placebo motherfuckers need to get the covid (for science of course) to trigger the first of the interim analyses. 

    Funny you mention this.  A bunch of the nurses and other docs in my office enrolled in the trial.  We all can easily tell who got vaccine or placebo due to side effects.  One of my partners who almost certainly got placebo came down with some congestion and had to get tested today.  I tried to tell him to look on the bright side how he might save a bunch of lives if he has COVID now.  

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  13. 6 hours ago, Borachio said:

    Update:  It's been 3 weeks since I had my second Moderna vaccine injection, so I got an IGG and total antibody test yesterday and both tests came back negative for antibodies.

    I was surprised by this given the reaction I had to the second injection (chills, fever, soreness, etc.) that lasted 24 hours.

    Must have been one heck of a placebo shot!

    I am on the Pfizer phase 3 vaccine trial.  Their mRNA vaccine is very similar to Moderna construct.  Had the exact same aches, fatigue, headache, and fever (102.7 F!) one day after 2nd shot given about 5 weeks ago.  Felt fine again after 24 hours.  No placebo (saline in Pfizer trial) is causing all of that.  Plus almost everyone in the Phase 1 trials had similar side effects after their 2nd dose.  I also got a commercial antibody test (Abbott’s test), which resulted negative.  I thought it was odd so I did research.  

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  14. 5 hours ago, Borachio said:

    Update:  It's been 3 weeks since I had my second Moderna vaccine injection, so I got an IGG and total antibody test yesterday and both tests came back negative for antibodies.

    I was surprised by this given the reaction I had to the second injection (chills, fever, soreness, etc.) that lasted 24 hours.

    Must have been one heck of a placebo shot!

    You prob got real vaccine.  Almost all commercially available antibody tests are for the nucleocapsid part of coronavirus.  Your antibodies would be to Spike protein so not gonna be positive by that test

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