-
Posts
173 -
Joined
-
Last visited
Content Type
Profiles
Forums
Store
Downloads
Recruiting - 2020
2019-2020 Football Season
Football
Entertainment
Sports
News and Business
Cloak Room
Transfer Portal
Recruiting
Events
Posts posted by Heme Doc
-
-
16 minutes ago, Newdoc said:
Not me. The guy’s a scientist first and foremost and respected at that. He’s not a good PR person especially off the cuff. He makes scientific statements sometimes without qualifications that a vast majority of Americans cannot process and he would end up scaring the shit out of half the country.
Good point
-
1 minute ago, Hagbard Celine said:
i speak jive, not pharmachem.
astrazenecaoxford nanotech: yes, or no. please. just one ping only.
No
-
15 minutes ago, Hagbard Celine said:
astrazeneca/oxford nanotech.
yes or no.
See reply to Bevo above.
But one interesting difference in the AZ/Oxford trial compared to Moderna and Pfizer trials is that in AZ/Oxford they actually did weekly nasal swabs in all participants (as opposed to only testing with PCR if participants had symptoms). And they found that the vaccinees had lower rates of asymptomatic infection, suggesting that the vaccine could stop transmission/block infection entirely (not just make you infected but asymptomatic). Moderna/Pfizer vaccines may do the same thing, but we don’t know that. I can’t wait to see this data, as we won’t have anything like this for Pfizer/Moderna.
-
40 minutes ago, Armybrat said:
How come doctors using all them bigass medical nerd words have such horrible penmanship?
Because we can’t spell for shit so it’s just a way to cover that we know how to say them but you’ll never know we can’t spell them
- 1
- 1
-
23 minutes ago, Bevo said:
I know you specialize in leukemia and lymphoma, and you aren't worried, and adenovirus is epichromosal, but I'm more worried about long-term effects from adenovirus products. mRNA or recombinant proteins for me.
I tend to be more nervous about adenoviral vaccines than mRNA vaccines also. Fortunately, it seems serious side effects with each have been quite rare. I believe that the AstraZeneca trial (adenovirus vector) was halted because of a case of transverse myelitis a few months ago. I don’t believe Pfizer or Moderna saw any issues like that. But if a serious side effect (say Guillan Barre) only occurs in 1:500,000 patients, then a clinical trial of 40,000 people might not pick it up. But you’ll damn sure see it once you start vaccinating millions of people. Hell, we still see cases of Guillan Barre each year with the flu vaccine.
Each person will need to make their own calculated decision about their risk of getting COVID and falling seriously ill or dying vs risks of the vaccine. From my look at the data, getting the vaccine (any of them) would be of significantly less risk for most.I’m hopeful that messaging from the new Biden administration and other mouthpieces in the government/medical community can clearly communicate to the public about some of these issues related to COVID vaccines including their effectiveness, safety, and expected side effects. I’d love to see Fauci go on 60 Minutes and lay out this stuff in an interview and at the end stand up and take the vaccine on TV.
- 1
-
2 hours ago, Anastasis said:
He's referring to your body mounting an immune response to the viral vaccine vector, in this case an adenovirus. The vector vaccines use a virus as the vector to deliver the genes coding for the spike protein to your cells. Your body will try to mount an immune response to the vector. The lower response rate with the higher first dose may suggest that a lower first dose followed by the higher second dose is less likely to stimulate the immune response to the vector.
I personally will line up day 1 my number comes up for an MRNA based vax. Not as comfortable with the vector vaccines until more data come out. Haven't decided what we are going to do with the kiddos (5-11) yet.
Top notch description of “vector immunity”
I tell everyone that the only thing I’ve noticed since getting the Pfizer vaccine is that my cock is huge (average size for Surl). I don’t mention that it was like that pre-vaccine.
- 1
-
2 hours ago, Brisketexan said:
If there's anything I hate, it's abbreviation of the duration of transgene expression.
Well, that, and the Dutch. I also hate the Dutch.
Similarly, there’s only two things that scare me. The risk of transverse myelitis or Guillan Barre after vaccination with an adenovirus vector.
That, and carnies. Small hands. Smell like cabbage.
- 3
-
Mondays are vaccine efficacy announcement days, it seems.
More good news from AstraZeneca. 90% efficacy in large phase 3 trial in group getting half dose vaccine followed by full dose one month later. Interestingly, the group that got two full doses of vaccine one month apart only was 62% efficacious. This is probably due to vector immunity. The delivery method for this vaccine is an Adenovirus, so some people probably mount more response to that and not Spike protein.
Another benefit of this vaccine is that it can be stored in regular refrigeration temperatures.
Starting to see the light at the end of the tunnel. Not sure exactly how long the tunnel is, but there’s light at the end.
- 1
-
On 11/18/2020 at 9:06 AM, conVINCEd said:
Get the meatballs.
Can confirm
-
Not worth it imo
-
21 minutes ago, NorthLoop said:
I like this Heme Doc guy.
Can we have him battle it out with ChiTownDoc? I mean I like ChiTown.. but he is a sooner fuck. But then again he does love clowining Trump dumbasses on the reg.
I like ChiTownDoc and wish to subscribe to his newsletter. I too enjoy clowning Trump dumbfucks.
- 2
- 1
- 2
-
Fuck this Dec 10 shit. Warp speed my ass. They need to move it up by at least a week
-
4 minutes ago, bschoolprof said:
I'm pro-vaccine, obviously, but the fact that mRNA vaccines are brand new (they've never been given before) and we have no evidence on their long term safety, I'm a bit nervous. I know the whitecoats tell me that, theoretically, the long run risks are small because the mRNA breaks down quickly, and efficacy is the real concern. However, jiggering around with our cells to produce virus spikes they weren't designed to produce gives me the heeby jeebies. What could possibly go wrong?
Anyway, I expect this will be the next great politicized nonsense that further tears away at the national fabric. Personally, I'd rather wait for the traditional vaccines that are in the works.
If I'm 80+ though, sign me up now bitches.
I totally get that perspective especially if you are younger and healthy. You’ll have some time to wait for more folks ahead of you in line to get the vaccine to make sure there aren’t any concerning safety signals. Plus, there will likely be more traditional vaccine types (inactivated/attenuated virus) come to market in 2021. The rare and more severe vaccine side effects like transverse myelitis or Guillan Barre usually occur pretty quickly after vaccination and haven’t been seen with these mRNA constructs. One very reassuring thing about the fantastic efficacy of the Moderna and Pfizer vaccines (both on par with HepB and MMR vaccines) is that is bodes very well for success of other vaccines that will be coming down the pipeline.
- 1
-
- Popular Post
- Popular Post
57 minutes ago, Texas Jeff said:I thought it might be helpful to have a separate topic related to the vaccine. If this is too much duplication, mods please delete this thread. I thought it would be good to talk about who can get the vaccine, where they can get it, what side effects people are seeing, and in general what is going on with distribution.
The CDC has published vaccine distribution guidelines, and if you care, they are worth reading. They are dividing the timeline into:
- Phase 1 - Potentially limited supply of COVID-19 vaccine doses available
- Phase 2 - Large number of vaccine doses available
- Phase 3 - Sufficient supply of vaccine doses for entire population
Who you are will determine if you are eligible for a vaccine in the various phases.
Phase 1 is divided into a Phase 1a and a Phase 1b:
- Phase 1a - Mostly healthcare workers
- Phase 1b - Other essential workers, people with higher risks, people over 65
If you are eligible to get the vaccine and they have in in stock and you want to get it, it is important to go get it. Both of the first two vaccines can spoil, so if a dose is sitting there and you aren't there to get it, they might have to throw it away.
Both vaccines require two shots. It is important to go get that second shot.
Who fits in phase 1b and who has to wait until phase 2 might be a sticking point. The "people in higher risks" category includes a lot of folks, maybe more than you would think might be in that category. Hopefully we can quickly get to phase 2 so that we don't spend too long arguing about who is or is not in Phase 1b.
Anyway, I'm interested in everyone's experience with the vaccine and especially getting the word out for those that can go get it, so that every dose ends up in an arm rather than in the trash.
Healthcare provider here.
Got vaccine (no doubt about it due to symptoms below) on Pfizer trial about 3 months agoArm sore for 2 days after first shot
2nd shot given 3 weeks later. The day after had arm soreness, headache, fatigue, chills/fever (102) and some body aches. Lasted 24 hrs then felt fine. Felt strange to be happy about feeling kind of crappy for a day.
Even though I’ve had the vaccine, I still am still very cautious at work (I prescribe chemo and see lots of immunosuppressed patients) and outside of work. I still do everything I can to protect my patients and family. The vaccines are not 100% effective and the trials only looked at symptomatic COVID infections, so I guess one could technically still carry it and be asymptomatic. However, recent data suggests that antibodies truly do prevent infection and not just making COVID infections asymptomatic.
Probably have EUA for both Pfizer and Moderna vaccines in about....2 weeks
If you can get the vaccine...Fucking get it. Side effects aren’t that bad and honestly feels great to not not worry as much about catching this shit. Also, there’s a bunch of patients in my clinic (and about 500,000 total in the US) who can’t get vaccinated because they’re on chemo or other medications or have some other immunodeficiency. We protect those people by getting vaccinated and getting to herd immunity.
- 10
- 4
-
1 hour ago, PenelopeWitherspoon said:
FUCK YEAH!
-
9 hours ago, Lobo said:
With the latest mid-week death tolls, the United States officially surpassed every last "shithole country" in terms of Covid-19 deaths per 1mm citizens.
But we are still doing better than Morocco. Which will likely be declared a "shithole country" by month's end.
Any news on blood type correlation to viral defeat?
Here’s the data best I know about looking at this question. From the Annals of Hematology in July
Bottom Line...”Blood type was not associated with risk of intubation or death in patients with COVID-19. Patients with blood types B and AB who received a test were more likely to test positive and blood type O was less likely to test positive. Rh+ patients were more likely to test positive.”
-
8 hours ago, Anastasis said:
Yeah. Seems pretty clear based what you and others are saying that blinding has been broken, at least for the subject paying attention. Saline don’t cause 24h fever spikes.
btw, welcome to the board. Can you clarify your position on ou. It’s 10:23.
Thanks for the welcome. OU sucks
- 3
-
43 minutes ago, Anastasis said:
Some of the placebo motherfuckers need to get the covid (for science of course) to trigger the first of the interim analyses.
Funny you mention this. A bunch of the nurses and other docs in my office enrolled in the trial. We all can easily tell who got vaccine or placebo due to side effects. One of my partners who almost certainly got placebo came down with some congestion and had to get tested today. I tried to tell him to look on the bright side how he might save a bunch of lives if he has COVID now.
- 1
-
32 minutes ago, Pato del Muerto said:
You got the abbot test on your own, or as the actual data for the trial?
I got it on my own
-
6 hours ago, Borachio said:
Update: It's been 3 weeks since I had my second Moderna vaccine injection, so I got an IGG and total antibody test yesterday and both tests came back negative for antibodies.
I was surprised by this given the reaction I had to the second injection (chills, fever, soreness, etc.) that lasted 24 hours.
Must have been one heck of a placebo shot!
I am on the Pfizer phase 3 vaccine trial. Their mRNA vaccine is very similar to Moderna construct. Had the exact same aches, fatigue, headache, and fever (102.7 F!) one day after 2nd shot given about 5 weeks ago. Felt fine again after 24 hours. No placebo (saline in Pfizer trial) is causing all of that. Plus almost everyone in the Phase 1 trials had similar side effects after their 2nd dose. I also got a commercial antibody test (Abbott’s test), which resulted negative. I thought it was odd so I did research.
- 2
-
5 hours ago, Borachio said:
Update: It's been 3 weeks since I had my second Moderna vaccine injection, so I got an IGG and total antibody test yesterday and both tests came back negative for antibodies.
I was surprised by this given the reaction I had to the second injection (chills, fever, soreness, etc.) that lasted 24 hours.
Must have been one heck of a placebo shot!
You prob got real vaccine. Almost all commercially available antibody tests are for the nucleocapsid part of coronavirus. Your antibodies would be to Spike protein so not gonna be positive by that test
- 5
COVID-19 vaccine discussion
in Daily Texan
Posted
You shouldn’t be worried.