Heme Doc

You shouldn’t be worried.

Good point

No

See reply to Bevo above. But one interesting difference in the AZ/Oxford trial compared to Moderna and Pfizer trials is that in AZ/Oxford they actually did weekly nasal swabs in all participants (as opposed to only testing with PCR if participants had symptoms). And they found that the vaccinees had lower rates of asymptomatic infection, suggesting that the vaccine could stop transmission/block infection entirely (not just make you infected but asymptomatic). Moderna/Pfizer vaccines may do the same thing, but we don’t know that. I can’t wait to see this data, as we won’t have anything like this for Pfizer/Moderna.

Because we can’t spell for shit so it’s just a way to cover that we know how to say them but you’ll never know we can’t spell them

I tend to be more nervous about adenoviral vaccines than mRNA vaccines also. Fortunately, it seems serious side effects with each have been quite rare. I believe that the AstraZeneca trial (adenovirus vector) was halted because of a case of transverse myelitis a few months ago. I don’t believe Pfizer or Moderna saw any issues like that. But if a serious side effect (say Guillan Barre) only occurs in 1:500,000 patients, then a clinical trial of 40,000 people might not pick it up. But you’ll damn sure see it once you start vaccinating millions of people. Hell, we still see cases of Guillan Barre each year with the flu vaccine. Each person will need to make their own calculated decision about their risk of getting COVID and falling seriously ill or dying vs risks of the vaccine. From my look at the data, getting the vaccine (any of them) would be of significantly less risk for most. I’m hopeful that messaging from the new Biden administration and other mouthpieces in the government/medical community can clearly communicate to the public about some of these issues related to COVID vaccines including their effectiveness, safety, and expected side effects. I’d love to see Fauci go on 60 Minutes and lay out this stuff in an interview and at the end stand up and take the vaccine on TV.

Top notch description of “vector immunity” I tell everyone that the only thing I’ve noticed since getting the Pfizer vaccine is that my cock is huge (average size for Surl). I don’t mention that it was like that pre-vaccine.

Similarly, there’s only two things that scare me. The risk of transverse myelitis or Guillan Barre after vaccination with an adenovirus vector. That, and carnies. Small hands. Smell like cabbage.

https://www.cnbc.com/amp/2020/11/23/oxford-astrazeneca-covid-vaccine-is-70percent-effective-trial-shows-.html?__twitter_impression=true Mondays are vaccine efficacy announcement days, it seems. More good news from AstraZeneca. 90% efficacy in large phase 3 trial in group getting half dose vaccine followed by full dose one month later. Interestingly, the group that got two full doses of vaccine one month apart only was 62% efficacious. This is probably due to vector immunity. The delivery method for this vaccine is an Adenovirus, so some people probably mount more response to that and not Spike protein. Another benefit of this vaccine is that it can be stored in regular refrigeration temperatures. Starting to see the light at the end of the tunnel. Not sure exactly how long the tunnel is, but there’s light at the end.

Can confirm

Not worth it imo

I like ChiTownDoc and wish to subscribe to his newsletter. I too enjoy clowning Trump dumbfucks.

https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-announces-advisory-committee-meeting-discuss-covid-19-vaccine Fuck this Dec 10 shit. Warp speed my ass. They need to move it up by at least a week

I totally get that perspective especially if you are younger and healthy. You’ll have some time to wait for more folks ahead of you in line to get the vaccine to make sure there aren’t any concerning safety signals. Plus, there will likely be more traditional vaccine types (inactivated/attenuated virus) come to market in 2021. The rare and more severe vaccine side effects like transverse myelitis or Guillan Barre usually occur pretty quickly after vaccination and haven’t been seen with these mRNA constructs. One very reassuring thing about the fantastic efficacy of the Moderna and Pfizer vaccines (both on par with HepB and MMR vaccines) is that is bodes very well for success of other vaccines that will be coming down the pipeline.

Healthcare provider here. Got vaccine (no doubt about it due to symptoms below) on Pfizer trial about 3 months ago Arm sore for 2 days after first shot 2nd shot given 3 weeks later. The day after had arm soreness, headache, fatigue, chills/fever (102) and some body aches. Lasted 24 hrs then felt fine. Felt strange to be happy about feeling kind of crappy for a day. Even though I’ve had the vaccine, I still am still very cautious at work (I prescribe chemo and see lots of immunosuppressed patients) and outside of work. I still do everything I can to protect my patients and family. The vaccines are not 100% effective and the trials only looked at symptomatic COVID infections, so I guess one could technically still carry it and be asymptomatic. However, recent data suggests that antibodies truly do prevent infection and not just making COVID infections asymptomatic. Probably have EUA for both Pfizer and Moderna vaccines in about....2 weeks If you can get the vaccine...Fucking get it. Side effects aren’t that bad and honestly feels great to not not worry as much about catching this shit. Also, there’s a bunch of patients in my clinic (and about 500,000 total in the US) who can’t get vaccinated because they’re on chemo or other medications or have some other immunodeficiency. We protect those people by getting vaccinated and getting to herd immunity.

FUCK YEAH!

Here’s the data best I know about looking at this question. From the Annals of Hematology in July Bottom Line...”Blood type was not associated with risk of intubation or death in patients with COVID-19. Patients with blood types B and AB who received a test were more likely to test positive and blood type O was less likely to test positive. Rh+ patients were more likely to test positive.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354354/

Thanks for the welcome. OU sucks

Funny you mention this. A bunch of the nurses and other docs in my office enrolled in the trial. We all can easily tell who got vaccine or placebo due to side effects. One of my partners who almost certainly got placebo came down with some congestion and had to get tested today. I tried to tell him to look on the bright side how he might save a bunch of lives if he has COVID now.

I got it on my own

I am on the Pfizer phase 3 vaccine trial. Their mRNA vaccine is very similar to Moderna construct. Had the exact same aches, fatigue, headache, and fever (102.7 F!) one day after 2nd shot given about 5 weeks ago. Felt fine again after 24 hours. No placebo (saline in Pfizer trial) is causing all of that. Plus almost everyone in the Phase 1 trials had similar side effects after their 2nd dose. I also got a commercial antibody test (Abbott’s test), which resulted negative. I thought it was odd so I did research.

You prob got real vaccine. Almost all commercially available antibody tests are for the nucleocapsid part of coronavirus. Your antibodies would be to Spike protein so not gonna be positive by that test