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Anastasis

Certifiably Surly
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Posts posted by Anastasis

  1. 1 hour ago, Newdoc said:

    This makes sense given the current epidemiology and risk for severe Covid disease in select populations.

    Agree. The booster recommendations have been outkicking the evidence coverage. This brings us more in line with the recs in the rest of the developed world. 

  2. On topic of the thread. More at the link that gets into the study design recommendations and other considerations. 

     

    https://www.nejm.org/doi/full/10.1056/NEJMsb2506929#f1

    An Evidence-Based Approach to Covid-19 Vaccination

    Authors: Vinay Prasad, M.D., M.P.H., and Martin A. Makary, M.D., M.P.H.Author Info & Affiliations

    Published May 20, 2025

    Over the past 5 years, the United States has moved toward an annual Covid-19 booster program. Each fall, Covid-19 booster shots are developed, alongside seasonal influenza vaccines, and are recommended for every American. As compared with vaccination policies in all European nations, the U.S. policy has been the most aggressive (see Figure 1).1 While all other high-income nations confine vaccine recommendations to older adults (typically those older than 65 years of age), or those at high risk for severe Covid-19, the United States has adopted a one-size-fits-all regulatory framework and has granted broad marketing authorization to all Americans over the age of 6 months.1 The U.S. policy has sometimes been justified by arguing that the American people are not sophisticated enough to understand age- and risk-based recommendations.2 We reject this view.

    Although the rapid development of multiple Covid-19 vaccines in 2020 represents a major scientific, medical, and regulatory accomplishment,3 the benefit of repeat dosing — particularly among low-risk persons who may have previously received multiple doses of Covid-19 vaccines, had multiple Covid-19 infections, or both — is uncertain. The American people, along with many health care providers, remain unconvinced.

    Over the past two seasons, uptake of the annual Covid-19 booster has been poor, according to the Centers for Disease Control and Prevention (CDC). Less than 25% of Americans received boosters each year, ranging from less than 10% of children younger than 12 years of age in the 2024–2025 season to 50% of adults over 75 years old.4 Even health care workers remain hesitant, with less than one third participating in the 2023–2024 fall booster program.5 There may even be a ripple effect: public trust in vaccination in general has declined,6 resulting in a reluctance to vaccinate that is affecting even vital immunization programs such as that for measles–mumps–rubella (MMR) vaccination, which has been clearly established as safe and highly effective. In recent years, reduced MMR vaccination rates have been a growing concern and have contributed to serious illness and deaths from measles. Against this context, the Food and Drug Administration (FDA) seeks to provide guidance and foster evidence generation.

    Moving forward, the FDA will adopt the following Covid-19 vaccination regulatory framework: On the basis of immunogenicity — proof that a vaccine can generate antibody titers in people — the FDA anticipates that it will be able to make favorable benefit–risk findings for adults over the age of 65 years and for all persons above the age of 6 months with one or more risk factors that put them at high risk for severe Covid-19 outcomes, as described by the CDC (Figure 2). For all healthy persons — those with no risk factors for severe Covid-19 — between the ages of 6 months and 64 years, the FDA anticipates the need for randomized, controlled trial data evaluating clinical outcomes before Biologics License Applications can be granted. Insofar as possible, when approving a Covid-19 vaccine for high-risk groups, the FDA will encourage manufacturers to conduct randomized, controlled trials in the population of healthy adults as part of their postmarketing commitment.

     

  3. 6 minutes ago, DaysOff said:

    Drinking tonight, so I'm having trouble with your point. So the anti vax HHS secretary is driving down cases by promoting not getting vaccinated? Help me.

    Maybe not everything that happens in the world is about us and our political dysfunction?

  4. Just now, Dbeasy said:

    Sorry I was quoting Anastasis. I have him on ignore now. I had never paid any attention to him before, and now that he demonstrated he’s literally too stupid to even understand the point of any discussion with him, it’s not worth ever engaging with that idiot again. He is mind-bottling dumb. 

    I see that we have entered the "bang on the table and yell" phase of the exchange. You are going to have to come to grips with what happened. There will be stages of grief that you have to work through. Its all part of the process if you want things to get better. 

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  5. 3 minutes ago, Dbeasy said:

    Oh cool. So you’ve just lumped all the bad politicians into one big pile and proclaimed them all the same. That’s real whatsboutism. You are truly a moron. But then we all knew that already. I just wanted to see you completely embarrass yourself for about the thousandth time, which of course you did. 

    You are clowning yourself. 

    If y'all can't even come to grips with how you got played by the Biden admi, the DNC, and the media, it does not portend well for the future. 

    • Fuck You 1
  6. Just now, Dbeasy said:

    So who have you voted for then? No one? Libertarian? How does sitting back and doing nothing but yanking on yourself somehow make you any better or smarter than anyone else? 

    All deflection from the fact that we had a clearly declined demented individual in the office, and the DNC and his inner circle and the media all ran cover for it. Whataboutism is cool I guess when it is based on delusions and strawmanning. 

    I voted Amash in 2020, and voted to go deer hunting in 2024 ftr. 

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  7. Just now, Dbeasy said:

    And you and others voted for a guy that has the same situation and worse. So what’s your point? Why is it bad when it’s Biden, and totally acceptable when it’s Trump?

    I haven't voted for any of these clowns. Just keep blindly pulling the lever for whatever the DNC busts in the back of your throat though. 

    3 minutes ago, jimmyjazz said:

    You said it didn't happen outside of academic settings, not me.  Your statement implied a universal truth that is absolutely not universal. 

    I also clowned on the people that use their academic titles in their social media handles. 

    • Fuck You 1
  8. 3 minutes ago, Dbeasy said:

    Ok, we don’t know the facts yet but let’s just assume they covered up prostate cancer. What point are you trying to make? That it’s bad? They shouldn’t have done that? The American deserved to know? 

     

    We had a clearly mentally declined, demented individual in the role of President. His inner circle ran cover for that. The media ran cover for that. Now they sell books about it. This is all totally normal and cool. Because orange man bad. 

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  9. 5 minutes ago, jimmyjazz said:

    And your experience is specific.

    Of course. But you told me that I have "no fucking clue" what I am talking about. 

    I don't really care what sort of academic dick measuring contests take place in your industry. 

    People with PhDs that roll around introducing themselves as Dr so and so outside of academic settings are generally pretentious little twats. And that extends to physicians to a certain extent as well, outside of clinical or academic settings.   

  10. 9 minutes ago, jimmyjazz said:

    You have no fucking clue what you're talking about, as usual.

    Literally everyone I work with, with rare exception, has at least one doctorate. Some clinical doctorates as well, MD, etc. And double dipping. Rare for any of them to introduce themselves as Dr. so and so or use their academic titles in normal professional exchanges. To the extent that they do, more typical for the physicians. Academic settings are of course different. And certainly clinical situations.   

  11. 11 minutes ago, Pancho said:

    Now make this same post about trump

    What about Trump??!!?

    Trump has NPD. Everyone with two eyes, no pdh or md required, knows that. Everyone in his inner circle knows that. Sorry you have to hear this from me. 

     

    The DNC and the media shit the bed with Biden 2024 guys. It will be ok. A little self reflection might be in order, but you aren't gonna want to hear that from me. I get it. 

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  12. 2 hours ago, Captainant said:

    DOGE cuts have caused the tornado early warning system to fail in Kentucky, I'm sure we'll get our turn in the barrel

    https://www.mesoscalenews.com/p/tornado-warnings-delayed-because

    https://www.foxweather.com/weather-news/deadly-tornado-outbreak-ohio-valley-kentucky-missouri-indiana

    18 confirmed dead with a higher body count feared as they clean up

    You just posted Rebekah Jones’ substack. 

    • Like 1
  13. Every one with two eyes, no phd or md required, knew that biden was mentally declined for a long time. Everyone in the inner circle certainly knew it. Everyone that has dealt with dementia and the aging process with family personally knows this. Again, no phd in ed psych or whatever required. They covered it up. It's pretty obvious. I would wager a large amount that they had indications of the prostate cancer over a year ago as well. No reason to believe that they did not cover that up as well. 

    Sorry that you guys have to hear this shit from me. 

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  14. 1 minute ago, aggie08 said:

    Why lie about something so patently false? What is your deal? In my experience, everyone that justifiable can put Dr. ahead of their title, does.

    I can't even believe that I am entertaining the notion of getting involved in a conversation with an aggie of how people with academic doctorates refer to themselves in real life situations compared to physician's use of the term doctor. 

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