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About PittsburghTiger

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  1. Thanks. I linked off my phone and it never goes fully.
  2. I have one of those stove-top ones that you stir the kernels. Makes the best popcorn
  3. https://mobile.twitter.com/nomiackerman/status/1246728816103481344?ref_src=twsrc^tfw|twcamp^tweetembed|twterm^1246728816103481344&ref_url=https%3A%2F%2Fwww.weaselzippers.us%2F WHO admits it blew off Taiwan’s warning so not to upset China
  4. I said that a week or so ago. I wondered how many of these young people also were vaping, especially with the counterfeit vapes that wreck the lungs.
  5. I think you are correct. https://www.bloomberg.com/news/articles/2020-04-05/india-bans-all-exports-of-trump-s-game-changer-virus-drug From Sunday India banned all exports of hydroxychloroquine, a malaria drug that President Donald Trump has repeatedly touted as a “game changer” in the fight against Covid-19. Exports of the drug and its formulations are prohibited “without any exceptions” and with immediate effect, India’s Directorate General of Foreign Trade said in an April 4 order on its website. The trade regulator had last month restricted overseas shipments of the drug, allowing only limited exceptions such as on humanitarian grounds and for meeting prior commitments.
  6. https://abc7.com/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/ Sunday, April 5, 2020 11:48PM LOS ANGELES (KABC) -- A Los Angeles doctor said he is seeing significant success in prescribing the malaria drug hydroxychloroquine in combination with zinc to treat patients with severe symptoms of COVID-19. Hydroxychloroquine has been touted as a possible treatment for COVID-19 by President Trump among others, but it remains controversial as some experts believe it is unproven and may not be effective. The drug has long been used for treatment of malaria and conditions such as lupus and arthritis but is not technically approved by the FDA for COVID-19. The agency, however, is encouraging trials and has provided limited emergency authorization for its use to treat COVID-19 patients. Dr. Anthony Cardillo said he has seen very promising results when prescribing hydroxychloroquine in combination with zinc for the most severely-ill COVID-19 patients. "Every patient I've prescribed it to has been very, very ill and within 8 to 12 hours, they were basically symptom-free," Cardillo told Eyewitness News. "So clinically I am seeing a resolution." Cardillo is the CEO of Mend Urgent Care, which has locations in Sherman Oaks, Van Nuys and Burbank. He said he has found it only works if combined with zinc. The drug, he said, opens a channel for the zinc to enter the cell and block virus replication. He added that the drug should not be prescribed for those who are presenting only mild symptoms, as there are concerns about shortages for patients with other conditions who need to take the drug on a regular basis.
  7. https://www.autoweek.com/racing/formula-1/a32038454/bernie-ecclestone-to-be-father-at-89/?source=nl&utm_source=nl_aut&utm_medium=email&date=040420&utm_campaign=nl19931517&utm_term=AAA -- High Minus Dormant and 90 Day Non Openers Former F1 chief executive Bernie Ecclestone is still busy in retirement. At 89, he is set to be a father for the fourth time, with his his third wife."It will be a boy," his wife, Fabiana Flosi, 44, told the Swiss newspaper Blick. She is six months pregnant.It will be Ecclestone's first son. The F1 chairman emeritus has three daughters: Deborah, 65, Tamara, 35, and Petra, 31.
  8. https://www.post-gazette.com/news/health/2020/04/05/Immunity-test-could-help-end-the-lock-down-covid-19-blood-test-upmc/stories/202004040002 Pitt close to immunity test
  9. https://www.spiegel.de/international/world/ischgl-austria-a-corona-hotspot-in-the-alps-spread-virus-across-europe-a-32b17b76-14df-4f37-bfcf-39d2ceee92ec there is the story from der Spiegel about the Austrian party
  10. https://www.businessinsider.com/coronavirus-stigma-wealthy-people-social-status-westport-ischgl-2020-4 Interesting story about how a couple parties early last month helped spread the virus.
  11. Hopefully something comes of it. Pitt really is a fantastic university, with shitty weather for about 5 months, with a top-shelf medical school. My dad was a freshman in medical school when Dr. Salk developed the polio vaccine.
  12. https://www.pittwire.pitt.edu/news/covid-19-vaccine-candidate-shows-promise-first-peer-reviewed-research University of Pittsburgh School of Medicine scientists announced a potential vaccine against SARS-CoV-2, the new coronavirus causing the COVID-19 pandemic. When tested in mice, the vaccine, delivered through a fingertip-sized patch, produces antibodies specific to SARS-CoV-2 at quantities thought to be sufficient for neutralizing the virus. The paper appeared April 2 in eBioMedicine, which is published by The Lancet, and is the first study to be published after critique from fellow scientists at outside institutions that describes a candidate vaccine for COVID-19. The researchers were able to act quickly because they had already laid the groundwork during earlier coronavirus epidemics. “We had previous experience on SARS-CoV in 2003 and MERS-CoV in 2014. These two viruses, which are closely related to SARS-CoV-2, teach us that a particular protein, called a spike protein, is important for inducing immunity against the virus. We knew exactly where to fight this new virus,” said co-senior author Andrea Gambotto, associate professor of surgery at the Pitt School of Medicine. “That’s why it’s important to fund vaccine research. You never know where the next pandemic will come from.” “Our ability to rapidly develop this vaccine was a result of scientists with expertise in diverse areas of research working together with a common goal,” said co-senior author Louis Falo, professor and chair of dermatology at Pitt’s School of Medicine and UPMC. Compared to the experimental mRNA vaccine candidate that just entered clinical trials, the vaccine described in this paper—which the authors are calling PittCoVacc, short for Pittsburgh CoronaVirus Vaccine—follows a more established approach, using lab-made pieces of viral protein to build immunity. It’s the same way the current flu shots work. The researchers also used a novel approach to deliver the drug, called a microneedle array, to increase potency. This array is a fingertip-sized patch of 400 tiny needles that delivers the spike protein pieces into the skin, where the immune reaction is strongest. The patch goes on like a Band-Aid and then the needles—which are made entirely of sugar and the protein pieces—simply dissolve into the skin. “We developed this to build on the original scratch method used to deliver the smallpox vaccine to the skin, but as a high-tech version that is more efficient and reproducible patient to patient,” Falo said. “And it’s actually pretty painless—it feels kind of like Velcro.” The system is also highly scalable. The protein pieces are manufactured by a “cell factory”—layers upon layers of cultured cells engineered to express the SARS-CoV-2 spike protein—that can be stacked further to multiply yield. Purifying the protein can also be done at industrial scale. Mass-producing the microneedle array involves spinning down the protein-sugar mixture into a mold using a centrifuge. Once manufactured, the vaccine can sit at room temperature until it’s needed, eliminating the need for refrigeration during transport or storage. “For most vaccines, you don’t need to address scalability to begin with,” Gambotto said. “But when you try to develop a vaccine quickly against a pandemic that’s the first requirement.” When tested in mice, PittCoVacc generated a surge of antibodies against SARS-CoV-2 within two weeks of the microneedle prick. Those animals haven’t been tracked long term yet, but the researchers point out that mice who got their MERS-CoV vaccine produced a sufficient level of antibodies to neutralize the virus for at least a year, and so far the antibody levels of the SARS-CoV-2 vaccinated animals seem to be following the same trend. Importantly, the SARS-CoV-2 microneedle vaccine maintains its potency even after being thoroughly sterilized with gamma radiation—a key step toward making a product that’s suitable for use in humans. The authors are now in the process of applying for an investigational new drug (IND) approval from the Food and Drug Administration in anticipation of starting a phase I human clinical trial in the next few months. “Testing in patients would typically require at least a year and probably longer,” Falo said. “This particular situation is different from anything we’ve ever seen, so we don’t know how long the clinical development process will take. Recently announced revisions to the normal processes suggest we may be able to advance this faster.” Additional authors on the study are Eun Kim, Geza Erdos, Shaohua Huang, Thomas Kenniston, Stephen Balmert, Cara Donahue Carey, Michael Epperly, William Klimstra and Emrullah Korkmaz, all of Pitt; and Bart Haagmans, of Erasmus Medical Center. Funding for this study was provided by National Institute of Allergy and Infectious Diseases grant R21-AI114264, National Institute of Arthritis and Musculoskeletal and Skin Diseases grants R01-AR074285, R01-AR071277 and R01-AR068249, and National Cancer Institute grant T32-CA175294. Media Contact: Erin Hare HareE@upmc.edu 412-864-7194 | 412-738-1097
  13. Field of Dreams was on this morning. It never gets old.
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