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bschoolprof

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Posts posted by bschoolprof

  1. 3 minutes ago, Js1 said:

    Until Gasso is gone, will it ever?  

    Nope.  We'll never get over the OU hump while she is there.  No one will honestly.  She's the GOAT for a reason.

    I'm a bit more disappointed in not really getting over the OSU hump.  We did sweep them last year, but we have been 3rd at best in the conference for a while now.  It won't get any easier in the SEC.  

  2. 8 hours ago, Anastasis said:

    Paxlovid talk a few pages back. NEJM this week. 

    https://www.nejm.org/doi/full/10.1056/NEJMoa2309003

    Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

    Authors: Jennifer Hammond, Ph.D., Robert J. Fountaine, Pharm.D., Carla Yunis, M.D., M.P.H., Dona Fleishaker, B.S.N., Mary Almas, M.S., Weihang Bao, Ph.D., Wayne Wisemandle, M.A., +5, and James M. Rusnak, M.D., Ph.D.Author Info & Affiliations

    Published April 3, 2024

     

    Abstract

    BACKGROUND

    Nirmatrelvir in combination with ritonavir is an antiviral treatment for mild-to-moderate coronavirus disease 2019 (Covid-19). The efficacy of this treatment in patients who are at standard risk for severe Covid-19 or who are fully vaccinated and have at least one risk factor for severe Covid-19 has not been established.

    METHODS

    In this phase 2–3 trial, we randomly assigned adults who had confirmed Covid-19 with symptom onset within the past 5 days in a 1:1 ratio to receive nirmatrelvir–ritonavir or placebo every 12 hours for 5 days. Patients who were fully vaccinated against Covid-19 and who had at least one risk factor for severe disease, as well as patients without such risk factors who had never been vaccinated against Covid-19 or had not been vaccinated within the previous year, were eligible for participation. Participants logged the presence and severity of prespecified Covid-19 signs and symptoms daily from day 1 through day 28. The primary end point was the time to sustained alleviation of all targeted Covid-19 signs and symptoms. Covid-19–related hospitalization and death from any cause were also assessed through day 28.

    RESULTS

    Among the 1296 participants who underwent randomization and were included in the full analysis population, 1288 received at least one dose of nirmatrelvir–ritonavir (654 participants) or placebo (634 participants) and had at least one postbaseline visit. The median time to sustained alleviation of all targeted signs and symptoms of Covid-19 was 12 days in the nirmatrelvir–ritonavir group and 13 days in the placebo group (P=0.60). Five participants (0.8%) in the nirmatrelvir–ritonavir group and 10 (1.6%) in the placebo group were hospitalized for Covid-19 or died from any cause (difference, −0.8 percentage points; 95% confidence interval, −2.0 to 0.4). The percentages of participants with adverse events were similar in the two groups (25.8% with nirmatrelvir–ritonavir and 24.1% with placebo). In the nirmatrelvir–ritonavir group, the most commonly reported treatment-related adverse events were dysgeusia (in 5.8% of the participants) and diarrhea (in 2.1%).

    CONCLUSIONS

    The time to sustained alleviation of all signs and symptoms of Covid-19 did not differ significantly between participants who received nirmatrelvir–ritonavir and those who received placebo. (Supported by Pfizer; EPIC-SR ClinicalTrials.gov number, NCT05011513.)

     

    image.thumb.png.0ddecca9701f61a4acba1198cbb665dd.png

    Yep, this is the EPIC-SR trial that I referenced earlier in the thread. Pfizer ended the trial early because it was a nothingburger.  Yet we still get bombarded with TV ads to take this thing when they've known for some time it doesn't work.  

    • Like 2
  3. Texas thoughts:

    Pretty disappointed by our offensive showing this past weekend.  I am not confident heading into this weekend.  We'll be lucky to take 1 out of 3 against OU, unless they are somehow massively overrated.  

     

    General thoughts:

    Is anyone else tired of all the reviews in college softball? One thing I like about softball, compared to say baseball or football, is the games are usually a crisp 1.5-2 hours. Now we have ump reviews and coach reviews and they take for fucking ever.  Ump reviews should be banned and each team should get 1 challenge.  

  4. 19 minutes ago, Mile High Horn said:

    Man, that was an embarrassing display of softball over the weekend.  I feel for the Texas fans in the stands who had to witness that debacle.  

    Leigh Ann Goode needs to start at shortstop. Viviana Martinez needs to learn how to catch a fucking ground ball.  

    We need to teach our baserunners not to leave early. This is a perpetual issue for a team that seemingly has not learned this basic concept.  

    We need at least one player to show some leadership and hold her teammates accountable.  Team captain Alyssa Washington has failed at being a leader thus far.  

    I wouldn’t be so frustrated if Oklahoma State were a better softball team and we executed basic softball fundamentals.  I think we lost a series to an inferior team this weekend.

    Agree with a lot of this, except Goode can't hit and Vivi can't field.  Pick your poison.  

    random thoughts:

    1) Who would have thought Mia Scott would be one of our more reliable infielders?  She had an error today, but has played relatively clean to me, at least given what I was expecting.

    2) The announcers said they asked coach about our hitting woes.  I didn't hear this interview, but he chalked it up not to approach, but just that our batters needed to work individually more on their swings and in the cages.  Couldn't disagree more and I think that's one of CMW's big weaknesses.  We just don't play smart softball sometimes.  There's a reason our patient hitters like Bella or a slapper like Maloney had the only hits of the day against OSU.  They don't chase and instead wait for their pitch. 

  5. I would have gone with Mac too, but our offense shitting the bed the last couple of weeks is the real issue.  I feel like a 3 run lead is insurmountable for us against a good pitcher.  

    One thing that's really frustrating is our our lack of adjustments throughout the game(s) as we see the same pitcher multiple times through the lineup or across games.  e.g., they like to throw changeups early and often?  Oh well, no way to beat that.    

    Kilfoyl has been good today, but not unhittable.  We are swinging at shit that's off the plate and getting into bad counts.  Our batters that have been patient today have gotten on.  We get one bad strike call off the plate and then we start swinging at everything off the plate.  At this point, I'd let blue ring us up before swing at shit that's an automatic out. But it's like our coaches never talk to the girls about this.  It's just the same shit over and over.    

     

    • Like 1
  6. 4 hours ago, ztejas said:

    What the fuck is Sendero Hills?

    It's a neighborhood in East Austin where old Alejandro, a maintenance man, used to live.  Due to rising rents/property taxes, he's been pushed out in favor of new Alejandro, an "urbanist" and bike dork.  

    • Like 2
  7. 26 minutes ago, Vic Mackey said:

    Sucker punch? Sure. But why do people act like there are rules when it comes to fights? This isn't boxing or some controlled setting. Your head needs to be on a swivel at all times

     

    • Hook 'Em 3
    • Haha 1
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