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Chopper

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Posts posted by Chopper

  1. 52 minutes ago, Orale said:

    Powerful Psychedelic Gains Renewed Attention as a Treatment for Opioid Addiction https://www.nytimes.com/2024/03/05/health/ibogaine-psychedelic-opioid-addiction.html?unlocked_article_code=1.bE0.qwgS.GH5zBfmeed-4&smid=nytcore-android-share

     

    Posting this on my phone so hopefully it opens. Interesting article about ibogaine for treating addiction. 

    fwiw I think that article would be better in the opioid thread because the med is to break addiction to opioids. Unless I misunderstood.

    Of interest in the heroin study article (for use for general anxiety disorder and depression) is they studied different dosage levels and also discussed the lack of "bad trips" when the drug is manufactured to a pharmaceutical level standard.

    Quote

    The multicenter, randomized, double-blinded trial tested doses of 25, 50, 100 and 200 micrograms compared with a placebo. “We’re very confident based on the results that 100 micrograms is the right dose to bring into our phase three studies, as we didn’t see any more improvement with 200 micrograms but did see additional adverse effects,” Karlin said.

    Quote

     

     Compared with experiences with forms of LSD purchased illegally on the street, the study’s grade of MM120 did not appear to induce “bad trips,” Karlin said. “LSD is difficult to manufacture with high purity and tends to degrade quickly in the presence of light and water,” Karlin said. “We’re manufacturing it to pharmaceutical industry standards, a highly pure version that is also shelf stable.

     

     

     

  2. Attempt to save $200M in a $45B deal through outright breach of contract. That's less than half of 1 percent (.0044) - reneged on by Elmo, and now he'll get to go to court, likely pay their attorneys' fees, and perhaps damages. The lawsuit describes the lengthy details Mosk went to...it's repulsive and tedious, though of course involves using spacex workers to carry out Mosk's own dirty work.

    Paragraph 90 is a lovely dig by Plaintiff's (Argawal, et al.) attorneys.

     

    image.png.05d6c6f17860b7ae774026589091d410.png

    • Haha 8
  3. Unearthed this thread for breaking news.

    Updated 8:16 AM EST, Thu March 7, 2024

    image.thumb.png.f811d7d22b1615e9cf27dca6b65b81c3.png

     

    image.thumb.png.1e9db9b6e27405f8b16fdcffec0e6548.png

     

    https://www.cnn.com/2024/03/07/health/lsd-anxiety-fda-breakthrough-therapy-wellness/index.html

    edited to add this para from the article -

    “While prior research has documented the benefits of combining LSD with psychotherapy to alleviate anxiety associated with life-threatening conditions, this groundbreaking study is the first to show that a single dose of LSD … can effectively treat generalized anxiety without the adjunct of psychotherapy,” said psychiatrist Dr. Gabriella Gobbi, a professor and scientist at McGill University Health Centre in Montreal and Canada Research Chair in Therapeutics for Mental Health. She was not involved in the clinical trial.

  4. 2 hours ago, Captain Ron said:

    Galloway blew this one up yesterday. He called this suit exactly what it is: Elon was dumb and got out too early and has serious sour grapes for that decision.

    Pretty sure I've mentioned to you before that imo Galloway only says the most obvious things that any idiot could come up with. Exhibit A bolded, below.

     

    On 3/2/2024 at 9:42 AM, Chopper said:

    Without getting all into the issue of AI, here's a couple other things I find interesting about this. When OpenAI was trying to raise $$ for their work in order to run it entirely as a non-profit, they received less than $150 Million in donations. They required a far greater sum to build and so created a for profit subsidiary, which raised something like $13 Billion to fund their efforts.

    I think once again Elmo made a bad deal for himself and he's having remorse, and so we see him acting out. For example, as posted above the first thing he's asked for is that OpenAI show him their work. They're not obligated to do so Just Because the parent company is a non-profit. Also IF if that were part of any deal Elmo made with them then that would be a central part of his lawsuit against them. But, as they say, if wishes were horses, beggars would ride.

    I can't wait to read OpenAI's response, they will almost certainly light him up. I'm no OpenAI or Altman fan so I have some mixed emotions about it but watching Elmo lose is much more fun. For now.

     

    • Hook 'Em 1
  5. 1 hour ago, Bevo said:

    I didn't know that about either. I thought they said Prince had the flu. I can't remember if they said overdose with Tom Petty or heart attack or something.

    It's one of the reasons why I get particularly pissed off when I read or hear someone dismissing the victims as dumb addicts, or a form of low life.

    https://www.rollingstone.com/music/music-features/musics-fentanyl-crisis-inside-the-drug-that-killed-prince-and-tom-petty-666019/

    Fuquan Johnson. Logan Williams (The Flash).

    Michael K. Williams.

    image.png.40b792acdf1beb456eb3b7c3f65ff975.png

    https://www.nbcnews.com/news/us-news/dealer-charged-actor-michael-k-williams-overdose-death-pleads-guilty-rcna78430

  6. 1 hour ago, gsoda3 said:

    just 6 months before the judge rescinded elon's comp plan the delaware court of chancery ruled that tesla's mid 2010s purchase of solarcity was "entirely fair" -  that although the board of directors (which included some of the same members as the later board that would later approve his pay package) could have taken additional steps to be more independent they were "entirely fair" to shareholders due to the resulting success of the implementation of the takeover.  this ruling, from june of 2023, was an upholding of a previous trial court's ruling from 2022 that found the exact same thing.  it confirmed the standard of independence that had always been used across the industry.  yet six months later the standard changed.  patently unfair.  

    To summarize your line of bs: "But but but under an entirely different set of facts, the court reached two different decisions. They should have reached the same decision because they both involved Elmo."

    Wholly illogical. Your grade is F in both law and logic, but I'll willingly cede you an 'A' for plainly expressing your strong desire to fellate Elmo. Courts apply differing facts to existing standards and reach different conclusions every day in the US. This is not news, nor is it controversial. For example, the same logic you used could easily be used to reach the opposite conclusion from you - the court sure did fuck up with that solar city ruling.

    Now go away for another few days, do your best research on your favorite site, elonmusksexdollowners (EMSDO) and come back with a better argument. Although I don't think you can.

    For the record, the ruling you noted was an APPEAL. Your boi will have his opportunity to appeal, don't worry.

     

     

    • Hook 'Em 6
  7. 1 minute ago, Chewbacca said:

    There wasn't even anything revolutionary in there.  Rich people like going to races and they like being treated like rich people?  OMG!

    Yeah fully agreed, seems pretty short-sighted to get the article canceled and just draw more attention. See: The Streisand effect.

    • Hook 'Em 1
  8. 4 hours ago, Bevo said:

    Fentanyl is a synthetic opioid. Similar to other opioid analgesics (pain relievers), fentanyl produces effects such as: relaxation, euphoria, pain relief, and sedation. A dose of 100 µg (0.1 mg) is approximately equivalent in analgesic activity to 10 mg of morphine (ie. It is 100X more effective). The principal actions of therapeutic value in medicine are analgesia and sedation.

    2 mg of fentanyl can kill someone. It kills by respiratory depression, meaning that you stop breathing. People generally start taking fentanyl after starting with other opioids such as Tylenol 3 (Tylenol with Codeine), Percocet (Oxycodone), Vicodin/Lortab (Hydrocodone), and Oxycontin (Oxycodone). Purple and lean is  codeine and promethazine cough syrup mixed with a sweetener. People move up to stronger opioids as they become more tolerant. So typically,people start with the light stuff and then later end up on stronger and stronger opioids. After taking opioids many times, the brain adapts to the drug, making it hard to feel pleasure from anything besides the drug. Some drug dealers mix fentanyl with other drugs, such as heroin, cocaine, methamphetamine, and MDMA. This is because it takes very little to produce a high with fentanyl, making it a cheaper option.

    Just would like to clarify because OxyContin and oxycodone should be distinguished. To my understanding:

    Oxycodone is used for palliative care and for patients with acute pain from (for example) cancer or surgery when no other medication is effective. It has a relatively short half-life. The medication stems from the opium poppy and it's been used in medications for many decades.

    Purdue Pharma originally created OxyContin to market oxycodone in a time-released capsule. Purdue Pharma marketed a product with extra-large doses of oxycodone (to get around half-life problems) and so it could be marketed as a 2x per day drug. They lobbied for and received a stamp of approval from the FDA for treatment of even mild chronic pain. Note the huge expansion in the legal user group they created. Of course many of those patients became addicted to the medication because of the large dosage, the problem became even worse because the capsule's timed-release mechanism was easily defeated, and the capsule could easily be crushed and snorted by addicts.

    OxyContin continues to be sold legally but the patients it can be prescribed to has been reduced, the amount of time any single patient may be prescribed it has been drastically reduced, and the time-release function is difficult-to-impossible to defeat.

  9. 43 minutes ago, MC Fresh Breath said:

    This all from an NYT summary.  And I know I make an assumption that I can trust that summary or even fully understand it all.  As a side note, your archive link didn't load for me. But truthfully I'm not going to read a 35 page document.  I have no sympathies or rooting interests for any billionaires.  But from the same NYT summary this was more what piqued my interest:

    Understood. I don't know why the link dithers. However if you cut and paste instead of just click, it's solid.  assets.bwbx.io/documents/users/iqjWHBFdfxIU/rYCUmwA4Xxpw/v0 -- again, pdf warning. Fwiw, bwbx.io is a bloomberg site

    Without getting all into the issue of AI, here's a couple other things I find interesting about this. When OpenAI was trying to raise $$ for their work in order to run it entirely as a non-profit, they received less than $150 Million in donations. They required a far greater sum to build and so created a for profit subsidiary, which raised something like $13 Billion to fund their efforts.

    I think once again Elmo made a bad deal for himself and he's having remorse, and so we see him acting out. For example, as posted above the first thing he's asked for is that OpenAI show him their work. They're not obligated to do so Just Because the parent company is a non-profit. Also IF if that were part of any deal Elmo made with them then that would be a central part of his lawsuit against them. But, as they say, if wishes were horses, beggars would ride.

    I can't wait to read OpenAI's response, they will almost certainly light him up. I'm no OpenAI or Altman fan so I have some mixed emotions about it but watching Elmo lose is much more fun. For now.

     

    • Hook 'Em 2
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