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  1. A few weeks ago I was looking at air B&B rentals in southern Oregon to escape the smoke in the Bay Area. Jobs and school are remote, and we're all on our devices anyway. Just awful to see it - looks like Paradise/Santa Rosa all over again. And still at least a month or two before we really start taking about rain in these parts.
  2. Totally. Life on Mars today.
  3. Mid day in the Bay Area was like a hour before dusk - except not pretty. Thick marine layer and heavy smoke above it has given us a brown-orange DARK sky all day. There really aren't words to describe the feeling. link
  4. Having just spent the long weekend along the Russian River up north (and the ocean beaches it reaches to), an additional issue right now is with the number of parks and beaches closed for COVID, the areas that are open get utterly swamped. PCH1 looked like the 405 on Sunday. That area is one my favorites, and kayaking in that kelp field off the shore of the Aquarium in Monterrey is amazing. Just be prepared as to say the current situation is dynamic is an understatement.
  5. Frankly, you might want to wait a bit - it's all on fire right now, from Santa Cruz to Healdsburg. Something like 1mil acres in a 100 mile radius of San Francisco. Air quality is unreal (except at the SF coast) all the way to Tahoe, there's no rain in the forecast until probably late October (if we're lucky). Most of our favorite wine spots in Healdsburg are closed now or had to evacuate. We have reservations in Guernville for Labor Day, and seeing as how the entire town is evacuated I seriously doubt we're going. Looking at a two week rental in Oregon to try and escape the smoke. Fuck 2020.
  6. It depends what you want, and it probably dependent on how this Fall goes. Likely no indoor attractions are going to be operational, and as noted other than sporadic sidewalk seating fine dining is a no-go. Some of the 'big' touristy stuff may be open - i.e. Pier 39 recently reopened. Outdoor tastings are popping up in wine country as well It could be a good time to do outdoorsy things, but the variable is you don't know if the parks will be open. For instance, some were closed to car traffic, but then access was pretty glorious by foot/bike. That said, San Mateo county was so fed up with people during the initial days of the lockdown they were stopping cars and asking for proof of residency in the area, and even cyclists were ticketed riding down from SF. In general, or at least at first, CA didn't suffer fools - we locked down. You certainly could still walk around the city, and some sites will always be accessible, but boy these are strange time - a lot of what makes SF the tourist draw is not open at the moment. As noted, great for us 'locals', though.
  7. That seems like a strange choice. I probably read too much in to it, but Yeager is such a strong presence in the movie and certainly was a huge influence on Wolfe's writing of the book. Will there be young girls and cookies in the Disney version?
  8. Putting aside the source of the information (or at least the vehicle), I watched the first talk by the woman who is stated to be an ER doc in California. She recited results from a J of Virology paper which shows that chloroquine is a potent inhibitor of SARS coronovirus, with the claim that as it was a 2005 publication that the 'cure' has been known for some time and it's all a coverup. I read the paper. It's an in vitro study using immortalized neonatal monkey kidney cells with chloroquine - it's all on cells. The maximum inhibition of the virus achieved was with an in vitro concentration which bears little relevance to clinically relevant exposures in people actually taking the drug. Touting this as a proof of a cure shows such a meager understanding of science and medicine, it brings forth the adage 'do you know what they call the person who graduated last in medical school?'. Let's just say we cure cancer in a dish all the time - patients are a bit harder. Surprisingly, no zinc was included in the assay, which based on the current diatribe also is stated as being crucial. I guess when you effectively paste on chloroquine at supra-physiological levels you don't need it?
  9. Unsurprisingly, a creepy crackpot who has problems forming sentences. Appearance on TV
  10. Well, nature has a way of dealing with those people. For the mRNA based Moderna vaccine it seems likely to require multiple hits. Not sure it’s necessary for the attenuated AstraZeneca/Oxford one.
  11. I'll admit, this is in Lake Tahoe, where anchoring = being close to shore, where there are big boulders. They'd much rather you float out in the 600'-1500' deeps...
  12. I think that's what the Swiss paper is arguing - children rarely infected the household. But honestly, we're dealing with such minuscule information at this stage, I think it's hard to understand all the permutations. Maybe Orange County will be the test case.
  13. Link to the above paper : https://pediatrics.aappublications.org/content/pediatrics/early/2020/07/08/peds.2020-1576.full.pdf?download=true It's a study from Switzerland, looking at families and family transmission from March to April of this year, 'the clinical presentation of the first 40 pediatric cases of COVID-19 in our city'. The positive read to the data is that ~80% of the time it appeared that the adults in the household appeared COVID positive first, and 'only' 8% of the time were the children positive. Note that in Switzerland schools closed in March and only just reopened in May (link). The potential conclusion here is that children are less likely to be the primary vector of transmission, I suppose. But if the schools were closed, does this really tell us much? And 'only' 8%, in a situation where perhaps the children are mostly sequestered, may underreport the risk (and they ackloedge as much in the paper). A longer rebuttal to my argument here, with additional global examples which may suggest that the potential transmission from child to adult is rare : COVID-19 Transmission and Children: The Child Is Not to Blame
  14. I'm hopeful as anyone else, mostly because mRNA vaccines may be the best approach from a scalability standpoint for a global pandemic. It's great to see there's a titer raised, but we don't yet know if it is effective (or protective). The adverse events with the 250ug injection mirror some of the moderate to severe reactions seen in previous trials with this approach in a cancer setting. Still a lot to understand with this system.
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