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Pato del Muerto

Certifiably Surly
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Posts posted by Pato del Muerto

  1. 7 minutes ago, YGIFS said:

    Yeah, I gotta give her partial credit.  For once, a lunatic GOP'er screaming, "IN TWO WEEKS!" actually did something they promised within a fortnight.  

    But if I'm the Democrats, I let this drag out as long as possible through procedural and floor debate drama.  It's one thing to humiliate her with such a resounding vote, but let her continue to humiliate herself and her party with some technicalities.  I don't get the rushed play here.  

    Let’s see if she does it again 

  2. 3 minutes ago, Jive Turkey said:

    way to go Moscow Marge.  way to take the spotlight off of all of the campus demonstrations that are hurting Biden.  way to shine it on the dysfunctional GQP.  

    this is going to be the big talking point for the next week or so.

    She trying to pry eyes way from stormy?

    2 minutes ago, Pancho said:

    359-43 to kill the motion to take out Johnson

    If they can just kill it, what’s the threat?

    • Hook 'Em 1
  3. Well, you seem to know that makar isn’t part of “the mackinnon line” or “their first line.”  I assumed a level of knowledge for those posting in this thread. 
     

    I know that makar, a defenseman, plays a lot. It feels like mackinnon, if not his entire line of 3 forwards that usually play as a group, also play a lot. 
     

    better?

  4. 1 hour ago, SydneyCarton said:

    We're overlooking maybe he doesn't care that much. Maybe he got his kid into their dream college, he gets to coach him, and he gets to get paid 1.5 mill for 3-4 years and ride off into the sunset. 

    Why would the lsu coaches asks to be paid a lot of money like that, and then say they won’t pay their players?  It’s almost like it’s non-sensical. 

  5. 2 hours ago, dcar00 said:

    The game winner against Otter wasn't soft but his positioning left much to be desired.  He over played the short side too much and couldn't get back.

    I think he was counting on miro preventing wood from cutting across the crease, so he came out to challenge head on.  But miro was tired and didn’t get the body or the stick. 
     

    anyone else feel like the mackinnon line is always on the ice?  I know makar plays a ton but it feels like their first line is out there a ton also. 

  6. 4 minutes ago, Brisketexan said:

    As have I.  Its core vulnerability is that it's just a fucking mutual agreement.  It's always been vulnerable to 1) abuse by the rich/privileged (ask a black dude from the past....entirety of US history....about that), and 2) a popular uprising against it.  That is, when enough people simply opt out of the mutual compact that is the Rule of Law, it's over.

    "I have this piece of paper that says you have to do X."  In a Rule of Law society, people do what the piece of paper says.

    In a Trumpian society, they say "fuck you" and go about doing whatever the fuck they want.  Which means that the only way you can require anyone else to do anything is with force/violence....which is exactly how the Trumpanzees want it to be.

    Could be why rulers of other civilizations tended to cloak themselves in a divine right to rule, to hold back the masses. 
     

    We tried to eschew that and for our troubles, the masses decided to cloak a monster with divine right to rule and press to install him on the throne. 

    • Rage+1 1
  7. I am ignorant to how long into long term effects monitoring we typically go before approving a drug. I have a hypothesis that the time from emergency use authorization to full approval may inform that timeline. 

  8. 5 minutes ago, BeardIP said:

    Ask yourself this, if there is no inherent difference in the manufacturing risks, then why not just make the process more efficient and turn the "fast track" into the standard? It's because the overwhelmingly likely reason is that by optimizing for speed, you are sacrificing something-- and whatever that sacrifice is (e.g. an uptick in risk) it's deemed worth it, but it's also not nothing.

    And like I said above, the increased risk is contained within the clinicals and borne by the volunteers. 
     

    if, for example, a normal dose escalation trial would start at x dose and increase until toxicity is established but in this case all of the dose cohorts are run in parallel, the higher dose cohort has higher risk because there’s no tox data available to inform dosing. 
     

    but at the conclusion of all of that, the final dose selected is based on the same overall trial data and just as safe as other dose decisions. 

    • Hook 'Em 1
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