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Anastasis

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Anastasis last won the day on May 18 2021

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  1. I like a plate full of a lot of small tacos.
  2. Twitter embeds should have been cut off on the non sports boards a long time ago. This is just a simple case in point.
  3. That has nothing to do with the being made. CMS data collection and sharing was a shit show, the non-CMS data is not much better. People were getting shots left and right without the admin being documented consistently to electronic healthcare data sources that are one of the primary tools used for post authorization safety surveillance. It's all understandable in terms of how it played out. The objective was the get shots in the arm. But the reality is that the exposure data is totally unreliable, in a world where these data sources already have significant limitations.
  4. The mechanism of action is very fundamentally different than any other prior vaccine approach used before. Inherently dangerous? Not sure I would use that formulation. Good reason to exercise some caution, certainly. There is great promise, if people can get comfortable with the technology and the proteins being coded for don't cause unintended effects. The reality is that safety profile of any new drug is really not established until well after market launch. In many cases until many years after launch. I think that if most people really understood how low the bar for safety is, and why that is (simple science reasons), many would be surprised. The reality is that the drug approval process is not able to catch (not powered to detect) meaningful safety endpoints. Shits got to be really off the rails to fail safety assessments during the pre-marketing phase. The real questions are answered after you get a few hundred thousand people to take it and get some "long-term" follow-up. The COVID vaccines are somewhat unique in that you had a huge number of people coming online in short time frame and in the context of a environment where they were literally just driving cars through parking lots at stadiums to get their shots. The first wave exposure data is an absolute mess.
  5. Here's a pew poll from 2005: https://assets.pewresearch.org/wp-content/uploads/sites/11/2005/04/EvangelicalsIsrael.pdf Evangelicals @ 63% yes when asked if Israel fulfills biblical prophecy about Jesus' second coming. Granted mainline and catholics are ~20-25%. The black church number in that poll is interesting.
  6. I don't see a problem with the accelerated emergency authorization process. In fact I think that they should have been more aggressive in early testing and done challenge trials. I think that the vaccine roll out was not optimized to first dose administration in this country, and that we could have done better and been less rigid with the second dose timing and probably saved a great many additional lives. I think that the mandate moves were wrongheaded and counter productive. And I think that we are in a totally different place today then we were in early 2021. This notion of putting mrna vaccines into 6 months old based on mouse model data is kinda crazy to me. This to the moon annual booster strategy seems ungrounded in strong clinical data. My whole family has received the primary series, and I og boosted. The whole family has hybrid immunity. I see no compelling reasons to keep boosting, although I have told my parents that there is no real harm for them. I am not sure that they benefit, but at their age the risk of long terms effects doesn't really register. I am not boosting my kids though unless something in the risk/benefit dynamic changes meaningfully. I am totally ok with people making whatever choices they want to make based on their own risk profile and decision making.
  7. I am not giving you medical advice, I am speaking to the level and quality of the clinical data. It would be nice if the medical advice from the regulators/public health authorities was based on something more than mouse antibodies and observational data. But boost to bolivia for all I care my friend.
  8. Weird flex. The clinical data do not support turning yourself into a pin cushion.
  9. It's about land and resources. It always is. Religion is just an effective motivator for the masses.
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