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triplehorn

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Posts posted by triplehorn

  1. 32 minutes ago, Neonmoon said:

    You’re blaming Fauci for not telling people to take Emergen-C? Seriously. You also going to get pissed when you find out he’s drinking water and exercising regularly? 
     

    Sweet Christ, the world is full of the dumbest fucking people. 

    EhzuITNU0AAGCgh?format=jpg&name=small

    Yet this:

    "When are we going to be able to sit in a theater and watch our favorite performers up on stage again?"

    "I think it's going to be a combination of a vaccine that has been around for almost a year and good public-health measures," Fauci told Garner.

    --->  nice summary here that shows, shockingly, that we won't be facing any resurgent threat from SarsCov2 in the future, and not a year from now either, with or without a vaccine:

    Spoiler

     

     

    I don't put all the blame on Fauci for no accountability and and no plan, but at some point you resign in protest to preserve integrity.  So where the hell is he really coming from?  it's a fucking head scratcher.

    • Fuck You 1
  2. 8 minutes ago, jimmyjazz said:

    That report is dated September 4th.  Much of the advocacy of vitamins C & D were rooted in general immune system theory along with a vast body of work regarding safe daily levels.  It wasn't a complete shot in the dark, but it was a safe "why not", as opposed to say HCQ (ahem).

    So you're bitching about a man who hasn't checked every single box to your satisfaction and criticizing his behavior when he has clearly been trying to tread a fine line in order to continue to inform the public as much as possible.

    Long story short:  you trivialize his ability to constantly advocate for masks and social distancing, and you prioritize his failure to meet your very specific standards for how he does his job.

    wow.  not true.  moving on...

  3. 25 minutes ago, jimmyjazz said:

    I've been taking both D and C for months now -- I don't recall if it was Fauci who I first heard regarding the efficacy of doing so, but it was definitely in the context of the coronavirus.

    Do you suppose we could stop looking for "gotchas" on Fauci, demanding that his work be not only unassailable but also 100% comprehensive?

    Even a hint of an actual organized directive and sense of urgency from Fauci would be appreciated.  He's a milquetoast.  Just my observation.

    With ongoing mounting evidence like this re covid and Vit D - Oral calcifediol, the main metabolite of vitamin D3, reduced ICU admission from 50% to 2% among Covid-19 patients - add this to the known list of available generic and safe options that should have led us out of this much farther by now.  smh.

  4.  

    We've had evidence of this for long enough that most likely more should have survived than one cares to contemplate.   For some reason, Fauci clearly has been in no rush to share it with all of us Americans.  It's inexplicable.  And I suggest inexcusable.  

  5. You can't be outside for any amount of time in PDX right now.  Visibility is reduced from smoke even at 20ft where I am yet the closest fire is 30 miles away. I just drove from from TX to OR last week and got caught in WY when I-80 closed statewide from that fluke hurricane snowstorm.  Drove through Green River WY where 80mph winds and snow wrecked big trees and structures.  17 inches snow reported on a mountain near Rock Springs WY.  Then right into the fire hell scape. 

    • Hook 'Em 1
  6. Ivermectin as a prophylactic in a study of healthcare workers in Argentina:  (n=1,195) with zero infection in the treated arm vs 58% in the other.

    Interestingly, they also give nasal spray and oral drops to inhibit the virus at point of contact.  They provide the dose ranges used when treating patients with active covid illness - totals about $15/day, cheaper than a partial* hospital bill.

    Ivermectin for people is readily available with an Rx from a PCP.  I give my dog ivermectin every month.

    My dog after 3 years of continuous Ivermectin:

    Spoiler
    35F5EB69-3307-4E99-AC73-021A99EF1737

     

     

    • Hook 'Em 1
  7. On 9/3/2020 at 7:48 AM, TwiceHorn said:

    Somewhere credible, I read that the average cost of an approved pharmaceutical from conception to approval was $1.6B.  I forget if that number included the cost of "failed" drugs that didn't receive approval or didn't go far in the process.

    "User capture" isn't a wholly "corrupt" phenomenon, but it is inefficient and throws into question whether the agency is really fulfilling its mission and doing so efficiently.  That is, user capture doesn't mean the FDA is doing its "customers'" bidding, but that the "dance" between agency and customer has become so routinized that its functions aren't being properly carried out.

    Outside of the large built-in costs of developing an all together new drug, what I'd like to understand is how these costs translate to working with the FDA to get use approval for substances that are naturally occurring and can't be patented, or use approval for older generics.  Ordinarily new use for older generics does't require additional FDA approval as off-label use is routine once initial approval occurs for any use, but that approval would ultimately be helpful wrt insurance coverage and patient affordability (with effects on the landscape of drug competition).  But for the former example, it wouldn't take  much of a cost increase working with the FDA to block availability and approval for a medical use when it's not big pharma's project.  This might come up where you have a naturally occurring substance that only has distinct therapeutic effects if given IV.  That can necessitate compounding by a pharmacy.  The FDA regulates what things are approved for compounding, and if the costs of doing that through the FDA are too high for anyone other than the big pharma co's, it likely gets smothered.

  8. 10 minutes ago, PsychMike said:

    This is from the study protocol, Page 4, beginning at Line 58:

    They used a loading dose plus high doses to get what they calculated as the levels needed to inhibit the virus. The key to getting effective kill rates with antimicrobials is getting sufficient drug levels to the target, while avoiding excess toxicity. It seems like a reasonable approach for a hospital study with adequate monitoring in the context of severely ill patients.

    Safety first.  If you're trying to translate in vitro results for in vivo human application, you first have to consider if the drug concentrations mechanistically effective in a glass contained experiment are safe concentrations applied to the human body.  If not, it's a no-go.  To my knowledge, the doses RECOVERY used were higher than any other known application, ever.  The early safety concerns for application in covid spawned entirely from this study.  OTOH, Low dose application has been repeatedly demonstrated to be safe in studies involving tens of thousands of covid patients combined and is associated with a massive beneficial treatment effect when applied before the second stage pneumonia crash happens.  It's currently thought to be its anti-inflammatory effect (like used for RA and SLE) as opposed to antiviral.

  9. 5 minutes ago, HenryJames said:

    You’re citing an ophthalmologist who let his medical license expire and was trading bitcoins when this all started as your expert on this.

    A French news outlet published an interview with a RECOVERY principle investigator.  The PI referenced amoebic dysentery dosing schedules as informing their dosing in a treatment arm of REVOVERY.  The drugs sound very similar, but the result of such a mix-up likely could finished off a number of patients, and misinformed the world at a very early stage.  Now they won't disclose their dosing methodology.  Just the facts.

  10. 3 minutes ago, TwiceHorn said:

    That stat about 75% of budget is misleading to the extent it implies that pharma donates that money.  As indicated by Mitch, it's PDUFA, the user fee act, that raised NDA application fees tenfold over less than 20 years.

    The issue with FDA, if anything other than being a bureaucracy, is user capture.

    The USPTO is entirely funded by patent application fees.  It is not subject to capture per se (its users are mostly pro-patent, true, but it is not beholden to any one company or industry), to the extent that Google had to insert its chief patent counsel, Michelle Lee, as Director, in order to pursue bigtech's agenda.  

    Thanks.  It sounds like pay to play.  Generally speaking, when NDA app fees increase tenfold in less than 20 years, it would appear that the result is one of culling the player pool and concentrating the the process to involve those companies that can afford to have a seat at the product approval table.  If I'm one of the big pharma heavies, I'm in favor of jacking up NDA application fees even more if it diminishes competition.  Again, this is not my lane, but that's one interpretation I make.

  11. 1 hour ago, Anastasis said:

    What does that have to do with dexamethasone  And other steroids clown? Hcq has rotted your brain. 

    Another dodge.  Shocked.  Anyone could respond with the flip a coin and forever be less wrong than you.  What gives?  It's amusing to say the least. 

    I've got no issue with dexamethasone at all.  Unlike other safe and inexpensive early interventions, unfortunately there's not any evidence yet to support its use in the early outpatient disease state.  Since it's available orally, it stands to reason it should be looked at in that capacity.  However corticosteroids like dexamethasone have broad effects on innate and adaptive immunity, so getting it too soon might have unintended consequences that need to be considered first.

    But yeah, RECOVERY fucked up with their hcq dosing, likely killed some people (you disagree?), and as a result mislead the world.

     

  12. I haven't dug into it.  Perhaps the language is more nuanced in terms of how and where the money flows, but if you search 'big pharma funding FDA', just lifting up a corner of that to see what's underneath is pretty illuminating.

    This article jumped out:

    Quote

    [...]  The FDA approved Oxycontin, the powerful narcotic pill that set off the opioid epidemic, in 1995 without clinical trials. The drug’s maker, Purdue Pharmaceuticals, convinced the FDA–and then doctors–that the drug was safe for widespread use in treating less-than-severe pain. The FDA then approved Fentanyl in 1998.

    Dsuvia, which is a more potent version of Fentanyl that comes in pill form, was developed by the California pharmaceutical company AcelRx in cooperation with the U.S. Department of Defense. In 2017, the FDA rejected the drug on the advice of an advisory committee, the Guardian reports, but when the company resubmitted the drug a year later it was approved. And members of the advisory board who had pointed out the drug’s potential for abuse, including Brown, were not invited to the approval proceedings the second time around.

    The most alarming part of the Guardian report is the idea that a crucial aspect of the FDA–the part that protects patients from harm from dangerous opioids–has effectively been privatized. A legal change in the 1990s allowed for more industry funding, and now the FDA division that approves new opioid drugs receives 75% of its funding from the industry. This, critics suggest, puts the FDA in the posture of a business partner of Big Pharma rather than a regulator.

    The story behind how we arrived at over $1B in US taxpayer dollars being used by Trump Admin to purchase the world's immediate supply of Gilead's remdesivir is another multi-layered story that will take time to unpack.  Gilead's stock value falling back to pre-pandemic levels should tell you how that worked out.  Swift maneuvering for a cool taxpayer Billion in exchange for piss.

  13. Ana, show me a single study in the history of ever that dosed 2,400mg in 24 hrs.

    Spoiler

     

    It ain't used for amoebic dysentery.  Now, probably with the advice of legal counsel, RECOVERY investigators won't share their methodology on how they arrived at near lethal dosing for their deadly RECOVERY trial, probably because it reveals they *confused* it with a similarly sounding drug used to treat amoebic dysentery.  shit happens, huh.

     

  14. dotard don't run.  

    I'll take it, but reducing mortality in "severely ill" patients is a Pyrrhic victory when better alternatives prevent advancing to severe illness and hospitalization in the first place.  And that RECOVERY trial overdosed its extremely ill subjects, possibly fatally,  in a particular treatment arm where they inexplicably dosed subjects in the first 24hrs an amount equal to what every other study gives over 5 days combined.  it was shameful, or worse ☹️ 

  15. 7 minutes ago, Irwin F Fletcher said:

    Probably as fast as we'll see him move. It looks like for a split second the security detail contemplated picking his large ass up.

    He 'runs' faster to the bathroom after Doral fish tacos and an Ivanka garden salad.

  16. 14 minutes ago, Doc Sam Beckett said:

    Lulz I don't know what that is, but it's not some natural fucking knock knees jenga gait. Jfc 

    Jenga!

    Spoiler

     

    You can see it's the identical gait right at the 48 sec mark walking away.  You will never find a video/gif of Trump running or even jogging, past or present.  Will ship a mixed sixer of craft ales anywhere for anyone who can find one.

     

  17. 23 hours ago, triplehorn said:

    It's hard to tell, but it looks like he might be knock-kneed.  You can see it occasionally with the right camera angle when he's walking.

      Reveal hidden contents

    cd7c92e4d8068eac0981018191f6ecb2.jpg

    It might explain why he wears pants tailored for MC Hammer - to hide his embarrassment over the uncoordinated looking contour of his legs.  When you get a huge gut and ass sitting on top of wobbly alignment, you might resemble a walking game of Jinga.  

    just saw this today.  Some seem to think this is evidence of a stroke.  To me this looks like him having knock-knees, with that Jenga gait. 

    .

    If it's knock knees, he had it growing up.  If he happened to have been mercilessly ridiculed about it in school growing up, that combined with those parents of his is a recipe for nuclear grade narcissism.  Of course he's bragged about being some kind of stellar ball player in high school or whenever, which serves to erase the painful memory of being the opposite.

  18. Mitch - Just pointing out what everybody already knows - the CDC's pandemic messaging and established policy implementation has been politically subverted since the beginning of this ordeal.  It sounds like you have a more familiarity with the longer arc.  No bones there.  The FDA is a different animal because of the influence of big pharma.  Harvey Risch at Yale school of Pub Health commented recently that FDA receives a third of its funding from big pharma.  I can't verify that.  Even if the FDA is walled off from the influence of big pharma, if you have a cheap generic that looks to be a slam dunk for a new indication going up against a patented product that is x200 more expensive per pt. and is less effective than the generic, pharma's less effective expensive drug wins out.  I expect this happens mainly because there is NO ONE who is going to spend the time and effort to promote the generic option.  Trump is inept at it.  And if you heard his convention acceptance speech, he made a comment about being worked over by big pharma and gave a facial expression suggestive of someone being rectally probed by an unapproved medical device.

    The relevant HCQ data is in:

    EgmLEmoXcAcloTt?format=png&name=900x900

     

    That is a massive treatment effect for low dose with early administration before pneumonia sets in.  6 independent studies from 5 western nations, meaning different potential biases and covariates between studies, yet highly consistent results in direction and magnitude among all 6 studies.  Over 35,000 subjects combined.  No new safety issues observed with HCQ in Covid using low doses of a med that has had FDA approval for 65 years and is used off label for tens of thousands of patients daily in the US. 

    Given the US covid caseload since March, best case is that those study results would translate into tens of thousands of Americans being alive today had this been utilized from the beginning.  

     

  19. I had forgotten about this re Erik Prince: 

    NYT:  Erik Prince Recruits Ex-Spies to Help Infiltrate Liberal Groups

    CNN: Erik Prince recruiting former spies to help with Project Veritas stings

    Be it Blackwater, Xi, or some yet to be recognized operation, trafficking in trained spies, agent provocateurs, and assassins is right up Prince's alley.  This deliberate election strategy targeting the American public to generate a spike in fear and division needs death and chaos to succeed.  Left-wing domestic terrorism and murder perp'd by "Antifa" is essentially a myth.  So if you're not getting the desired level of death and chaos in the streets, what is someone like Erik Prince with his like-minded assets capable of coordinating to push it over the edge?  When Trump tweets that we haven't seen nothin yet re the course of protests in "Democrat cities", in this case it's probably fair warning about whatever is planned next.  

     

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