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Anastasis

Certifiably Surly
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Posts posted by Anastasis

  1. 1 minute ago, Bevo said:

    You still have to make sure that the protein that is expressed doesn't change homeostasis/have deleterious effects. 

    Right, but if we can get there with the tech generally, maybe we can find a streamlined way to get there with the specific protein expression in an expedited fashion.  The mRNA tech reduced the timeline for time from identification to testing significantly.  That has already been demonstrated. Can we find a way to compress further with broader testing of the tech. I think so. Maybe I am just being optimistic, but as far as pandemic killers, this appears to be our best weapon. 

  2. Feeling pretty flushed with optimism after the second EUA (and maybe more than few long pours from the bourbon stocks), but I think that the mRNA technology has the potential to be the pandemic killer.  Not just the COVID-19 pandemic, but potentially future pandemics as well. If we can establish the safety of the technology generally, through future research applying to influenza and other viral and maybe bacterial infections, with a consistent safety profile, perhaps we can feel comfortable with a blanket approval of the technology no matter what viral/bacteriological protein is being expressed.  If we can get to that point, we have a rapid response laid out. The mRNA technology allows for a very quick move from sequencing of the infectious disease to vaccine production...moving much faster than previous technologies. In this case, it was 25 days from sequencing to first vaccine production. If we can get comfortable with a blanket approval of the process, it is a game changer and may mean that we don't have to live this ever again. Sequence, vax production, initial roll out needs to take no longer than a few months with the infrastructure in place to respond. 

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  3. 10 hours ago, XYZ said:

    The fucking media seems to latching on to every solitary instance of something going sideways with the covid vaccine. I bet that every year when millions of people get the flu vaccine, some people faint or get an allergic reaction or whatever.

    No shit.  This is dumb and totally predictable. But meh clicks!

  4. 4 minutes ago, JimmyJames said:

    Not sure if you were referring to me or not but in case you were, I was joking. Sort of.

    You don't know if I was referring to you when I said "Two of the standard bearers unable to differentiate the real threats from the crazy ass conspiracy nonsense chime in within seconds." when you are one of the only two posts that responded to me within seconds of my post?

     

  5. 16 minutes ago, LurkingHorn said:

    Moderna vaccine approved for emergency use. Let’s go!!

    LFG. 

     

    What is sad is that everyone knew this was the inevitable outcome in mid November when the data were released, and we should be on the second round for the first wave at this point. 

  6. 9 hours ago, Doc Sam Beckett said:

    Oh. My. God. It's always Russia Russia Russia with you people! 

    /@Anastasis(probably) 

    It's not my fault that you guys lack the ability to focus on the actual real geopolitical threats posed by Russia versus the conspiracy land fan fiction nonsense that has dominated the last 3+ years of the discourse. 

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  7. 3 minutes ago, BradInATX said:

     

    In a debate on incompetence between the second biggest pharma in the world with a $200 billion market cap, and the Trump administration, I'm always going to go latter until proven otherwise. Because my IQ is, perhaps barely, not below 60.

    I tend to agree, but PFE specifically chose to go their own route. Seems to be a bit of messaging to turn around and blame the lack of interoperability on the government.  This coming from someone inclined to blame the government for every break down. 

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  8. Just now, BradInATX said:

    Their press release reads that they have a bunch of vaccines sitting in a warehouse with no direction from the government, and they've offered more capacity with no response. What am I missing?

    They specifically decided to run an alternate distribution logistics system, separate from HHS's programs. They appear to be blaming the disconnect on HHS, which I am inclined to believe. But I think maybe we should consider the fact that PFE choosing to run a totally separate distribution network outside the feds/McKesson instead of integrating into that may also play a significant role.  

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  9. 1 minute ago, BradInATX said:

    It's Pfizer's fault that they decided to integrate with the HHS system and said HHS system turns out to be garbage?

    That's literally a direct analogue to blaming the beaten wife for not seeing her husband's future potential for wife beating. Fuck's sake, man.

    They specifically decided not to integrate with the federal government system.

    I was inclined to think that they had made the right decision and that their production and logistics would prove superior. 

    Doesn't appear to be the case. 

    What I see is a bunch of deflection at this point because both their supply chain and logistics are not really performing. 

  10. 2 minutes ago, HenryJames said:

     

    PFE fucked up their supply chain and now their logistics breaking down.  They chose specifically to dial out of the McKesson system that was tied into HHS/WarpSpeed/Whatever. At one point that appeared to present them an advantage.  Maybe not so fast my friends. 

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