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Posts posted by Anastasis
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1 hour ago, Both Tacos said:
I would seriously look at the pro series on the Blackstone if I was buying right now.Â
This.Â
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@Cajun did you try any of the tracking modes?
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5 minutes ago, SimonBolivar said:
How will I know what to think now?
There is always twitter to help us out.Â
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38 minutes ago, BradInATX said:
Anastasis and several other Trump supporters
Don't make me neg you.Â
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53 minutes ago, tantric superman said:
Pretty much throwing down the David Sedaris line for anyone who says something as stupid as that.
To put them in perspective, I think of being on an airplane. The flight attendant comes down the aisle with her food cart and, eventually, parks it beside my seat. “Can I interest you in the chicken?” she asks. “Or would you prefer the platter of shit with bits of broken glass in it?”
To be undecided in this election is to pause for a moment and then ask how the chicken is cooked.
Â
Why would you eat anything out of the airplane galley where they are preparing platters of feces? I bet it all tastes like shit after comingling. Â
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Yeah I agree.Â
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On 10/13/2020 at 10:15 PM, deft said:
Pretty sure I saw parisa at schotts market, hwy 16 just west of 1604. About 10 minutes from the house so I’ll try to check it out again soon. Not Medina county.
IIRC there used to be a schotts in Castroville. It turned into a super s or some other shit and maybe something else now. Anyways, whatever the grocery store was there use to keep it in the  cooler.Â
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Jesus Christ if I saw a buck like that on my little spot in Medina county I would probably blow the shot cause I had the shakes. Â
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That is one fine ass automobile.Â
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2 hours ago, Bama Chick said:
Branded Tamiflu costs between $175-250 without insurance currently.
It was launched in 1999 and I couldn’t find anything on the Google about its launch price.The cost-effectiveness of Tamiflu has long been a topic of debate. It's not particularly low cost, nor effective. Not really a great example in this discussion.
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2 hours ago, jimmyjazz said:
Do you agree that there is some concern about vaccine penetration X efficacy?Â
My thinking is basically:
1) Get a vax to market ASAP, prioritized to high risk individuals.
2) Roll it out in waves based on risk profiling.
3) Continuously collect surveillance data to red flag any safety issues as they emerge.
Â
I will line up for a shot from PFE or MRNA as soon as they call my number. Sure concerns about efficacy. We don't know one way or the other until the data are read out. Penetration? Everybody that is in my close circle will be lined up. I am more than willing to shame anyone who is not, with rare exceptions.Â
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Spent some time in Asheville right before COVID. REally enjoyed it.Â
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7 minutes ago, Brisketexan said:
Goddamn....those moments for me seem like a million years ago. And as exhausting and trying as those times often were.....shit, your little girl falling asleep on your shoulder.....that was the good stuff. Drink it up, man. All three of you earned it.
This. When my kids were younger, and still to today, people would tell me to soak it up. "These are the moments you will remember forever." It was hard to process at the time, knee deep in shitty diapers, sleep deprived, and making all the adjustments and sacrifices. But I even now, with all three still in the process, look back and I really missed out on savoring some of it. And I now, still only to a modest extent, appreciate the wisdom that I still have not completely brought to ground day to day. Went to a funeral today for a friend and father who passed far too soon with a beautiful family. Relish what you can man. Nothing is promised tomorrow.Â
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2 hours ago, atomheartbevo said:
Someday, we might elect some good Christians, who have a sense of empathy, who want to help the poor, like all that stuff Jesus taught about.
Those people are shunned from the political establishment on #bothsides for very different, but ultimately related, reasons. Â
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5 hours ago, jimmyjazz said:
I am not aware if such a therapeutic would be a "unicorn". Is Tamiflu effective at reducing the symptoms and duration of the flu? Would such a thing be overly optimistic for covid? (Just to be clear, I'm not suggesting the use of Tamiflu for covid. I'm asking if a "Tamivid" could be found with more money thrown at the problem.)
Any idea what Tamiflu costed when it was launched to market? Not really an example that meets your two prongs.
Â
Triple actually has a good point that in order to meet the requirements laid out you have to screen existing drugs for cross over effect on COVID. There was a lot of effort put into HCQ exactly for that reason...low cost, oral administration, widely available, etc. That's why a lot of people were optimistic when the initial dat, based largely on bad animal models circulated. Unfortunately it just didn't pan out. I do think other candidates deserve a fair shake. But at this point we are very close to a vaccine EUA, and I think that complaining about the investment in that program is wrong headed.Â
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5 minutes ago, jimmyjazz said:
If an effective therapeutic were widely available at a reasonable cost, I'm not entirely sure I agree. Imagine a treatment that virtually guarantees the course of the disease will be mild. Combined with moderate ongoing immunity for a few months, covid could transform from a lethal pandemic to "shit, I'm down for 3-5 days once or twice a year", kinda like . . . the flu or a rhinovirus.
Well sure if you make assumptions on the extreme end of potential effect size and cost, you can probably come up with a different conclusion. Those assumptions however do not appear to have any basis in the reality of the therapeutics that have been evaluated against this viral disease. Maybe the unicorn you describe exists in the wild and has been missed. It's quite possible. OTOH, we have actually made meaningful effort towards standing up huge clinical trials and a manufacturing infrastructure in unprecedented time. I think that the money was well spent and appropriately prioritized. Â
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New admit number fucking sucks. Ratio of 0.25 for new daily admits/new daily cases seems like shit.Â
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I'd say that they made the right choice in terms of priorities. 10%, not 4%, went to therapeutics if you are comparing the proportion of COVID funds.
There does not appear to be a way out of this until we have a broad vaccination program. I don't really see a problem with a disproportionate focus on driving vaccine development and manufacture. They are trying to accelerate a process that typically takes many years into a time frame measured in months. No rational person wants to divert money from vaccine development to more HCQ trials or other very low effect size potential treatments.
Meanwhile, instead of more negative HCQ trials, PFE announces that they will likely be prepared for an EUA application in mid November. This is absolutely unprecedented from a vaccine development process.Â
Â
Bourla’s letter includes three new details:
— Pfizer and BioNTech will have two months of safety data on half the patients in their 44,000-patient vaccine study in the third week of November, based on current enrollment rates. This would allow the companies to file for an emergency use authorization.
— The independent data safety monitoring board, a panel of experts monitoring the study, will conduct interim analyses of the effectiveness of the vaccine. This is what originally drove the October timeline.
— Pfizer said that it “will share any conclusive readout” from these interim analyses, be they positive or negative, but that the study will continue until its conclusion.
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PFE will wait until after election to submit their EUA application; however, initial efficacy data will read out earlier.
Bourla’s letter includes three new details:
— Pfizer and BioNTech will have two months of safety data on half the patients in their 44,000-patient vaccine study in the third week of November, based on current enrollment rates. This would allow the companies to file for an emergency use authorization.
— The independent data safety monitoring board, a panel of experts monitoring the study, will conduct interim analyses of the effectiveness of the vaccine. This is what originally drove the October timeline.
— Pfizer said that it “will share any conclusive readout” from these interim analyses, be they positive or negative, but that the study will continue until its conclusion.
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2 minutes ago, SydneyCarton said:
It's frustrating. There isn't really a viable news channel I can go to when I want a news update at off hours, because evenings are dominated by our son. BBC is fine, but it's a worldwide focus. PBS is at the wrong time. There isn't a fucking news channel that cares about delivering the news, just like ESPN isn't a fucking sports news network it's sports entertainment. It pisses me off there isn't an alternative out there. Capitalism at work.Â
News doesn't hold enough of the eye balls the marketing people need. Entertainment sells. Conflict sells. Punditry sells. Whacked out shit that either reinforces the perspectives of the extremes, or is just grotesquely amusing enough to grab some eyes from the center, sells. So that is what we get. Â
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7 minutes ago, Bookman said:
This election doesn't feel anything like 2016. I think Biden is going to win big and it's a coin flip for Texas to go blue.
He’s gonna win bigly.Â
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LSU chick wins that fight going away.Â
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Lilly’s trial was paused by the safety monitoring board a few days ago.Â
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Formerly DT: COVID-19 - Featuring Lots of Politics, now CR because political talk not going away
in Cloak Room
Posted
If only nature would come up with some way to deal with some of them.Â