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Dontshootrude

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Dontshootrude last won the day on September 7

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  1. That is a good article. This one is pretty good too. https://www.bmj.com/content/374/bmj.n2320
  2. The danger of the preprint server just showed up. https://www.medrxiv.org/content/10.1101/2021.09.13.21262182v2 https://www.cbc.ca/news/health/covid-19-vaccine-study-error-anti-vaxxers-1.6188806
  3. This is probably purely coincidental, but there was a study published earlier this month that screened the national blood supply (about 1.5 million people) for infection and vaccination antibodies and it was determined about 20% of the population had COVID as of May 2021, which is about what the survey reflects at the time of me writing this post. https://jamanetwork.com/journals/jama/article-abstract/2784013
  4. People in your situation have demonstrated the most robust immunity of any group. The reported breakthrough cases for recovered and vaxxed are the lowest of any category. There have been several studies that show you are not only able to defeat COVID, but a couple of the cold like coronaviruses and even the original SARS virus. At this point I don't see any reason for you to get a booster.
  5. JCS Criminal Psychology YouTube channel needs to be on the first page. It is one of my favorite channels.
  6. At this time last year GT was down 52-7. So this is a nice change.
  7. COVID vaccine immunity is waning — how much does that matter?
  8. I've only read the letter. Do you have a link to the full report?
  9. Oh, I agree. I just like to go with the flow. See where it leads me.
  10. Interesting MMWR published today. https://www.cdc.gov/mmwr/volumes/70/wr/mm7038e1.htm?s_cid=mm7038e1_w Key table: Moderna dominance continues. This is in 21 hospitals. It is good news, but Jesus, the UK and Israel are making the US public health system look horrible. Our data sets are small, inconsistent, and fragmented. It is really difficult to get good large scale data sets in the US in a timely fashion. The pandemic has really exposed how vulnerable and unorganized we are.
  11. Funny/CSB story. CDC has protesters come and go, but there is one dude that is always right outside CDC rain or shine, hot or cold, with about 10 signs walking up and down the sidewalk that say things like "Infertility," "Genocide," "Obey," etc. As crazy as he is I tip my cap to him for being so incredibly dedicated and so confident in himself that he can do that just about every day by himself. It is a shame he has latched onto something this crazy, because if he would have picked something productive no doubt he would have been highly successful. Something tells me the Nicki Minaj protesters won't be so driven.
  12. That nature review on lipid delivery of mRNA was interesting It lead me to this paper in which people got eight shots and they were continuing to develop good immune responses. That is encouraging news and helps alleviate my concerns regarding decreasing efficacy due to the immune system recognizing the capsule! As to the other papers, those were published right as we were mass deploying the vaccines. I was more concerned then, but thankfully recent data has held up well, especially against severe disease. I'm optimistic that will continue. ETA: I also found the references that highlight the diverse array of vaccine induced epitopes and how well they are holding up for the vaccines. https://www.biorxiv.org/content/10.1101/2021.02.27.433180v1 https://www.sciencedirect.com/science/article/pii/S2666379121002044
  13. I disagree. Truth is there are fundamental biological reasons why I think it unlikely that COVID will be able to find a mutation that will significantly escape our vaccines. When replicating, coronaviruses, including COVID, have a proofreading mechanism (PDF warning) that will verify the genetic sequence that is being replicated. It is not as robust as that in eukaryotic cells (human, mammals for example) whence the mutations we do see, but it does exist. Compare COVID to a true rapidly mutating virus like flu. Flu has two mechanisms that allow it to radically mutate in short periods of time. 1. Genetic drift - random point mutations in the genome from the highly error prone replication enzymes that lack proof reading that it uses to replicate its RNA genome 2. Genetic shift - completely swapping out entire gene segments for new ones creating a whole new unique flu virus. Only Influenza A viruses can do this which is why they are responsible for the pandemic strains. To highlight this, check out the two files attached to this post. The COVID_Variant_Alignment file are the top five variants of concern aligned against the original COVID sequence provided to CDC back in January 2020 that the vaccine was designed against. An * under the specific base means the nucleotide is the same among all six strains. Notice how much of the sequence is the same among all six, and you really must hunt to find changes. I've also attached an alignment from a surface protein of flu, a true rapidly mutating virus for comparison. Notice how inconsistent the flu is and you'll see why it is so challenging to design effective vaccines and therapeutics. Shifting back to the vaccines, the spike protein is a big protein. I've seen studies that report CD8+ (T killer cells, the ones that seek out and kill infected cells) recognizes 52 epitopes (spots on the protein). CD4+ cells (T helper cells, which help drive antibody responses) recognize 23 epitopes across the entire spike protein. I'll try to find my references for this later, but offhand I can't recall exactly which study addressed this. It is hard to imagine, given how stable COVID is, that it will find a way to alter all of these regions and still remain infectious. Comparing the Beta variant vs Delta is encouraging too. Beta is actually more genetically distant than delta and the vaccine was less effective against it compared to delta. But Delta has outcompeted it nonetheless. This is a good article that partially addresses what I'm saying above. And one finally thing I should mention regarding the immune response to the lipid capsule delivery vehicle. I wouldn't say I'm extremely worried about this. I'd just like to see it addressed before I take a shot that decreases my risk of hospitalization from 1 in 300,000 to 1 in a couple of million. COVID_Variant_Alignment.txt Influenza_H1gene_alignment.txt
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