I absolutely believe psychedelic drugs need to be looked at as a serious option for people with long term mental health issues.
I'm now 2 years away from ending my marriage. Wife struggled with depression since childhood. I loved her and believed it could be manageable, but it wasn't. Our child was 4 years old when we separated. Will never forget sitting him down and telling him. My little fucking badass hero. Handled it like a champ and I believe he's happier today than he's ever been. I come from a family with no divorces, she comes from a family with multiple divorces everywhere. Truly the hardest years of my life seeing my family dreams unravel, but the work I've put in as a parent is paying off.
She lives in therapy. We went to multiple couples therapists constantly. Literally didn't move the needle in a positive direction at any point. Finally she decided to get an in-depth evaluation from Menninger. Laundry list of issues - Severe depression, ADHD, childhood trauma, alcohol, etc. They recommended 45 day in patient rehab and she was a on a plane to Arizona a few days later. They were concerned about her drinking habits and its possible effect of dulling/neutralizing her medications. I was skeptical, as she basically had a couple of glasses of wine a night. She never got super drunk, or angry, or flip a switch personality wise. I told Menninger people that if my wife was an "alcoholic" then I've got about 60 other functional good friends that are alcoholics.
Anyways, she completed 45 day rehab and got sober. Nothing changed. I continued to research stuff myself to find answers and the light bulb went off when I came across Narcissistic Personality Disorder. It really seemed to check all the boxes. No one has diagnosed her with it, but I fully believe this is the main issue. Highly recommend deep diving into NPD info if you're struggling to identify mental issues with someone close to you. There are many different spectrums to NPD. Don't assume narcissists are just the extroverted people that are easy to notice. And I think NPD cases are going to rise quickly with our current culture and technology advances (particularly social media) that will only make it worse.
Like other personality disorders, common belief from professionals is that NPD can't be "cured". A person can work hard to manage it, but it is hard-wired in to their brains, most likely from childhood trauma that is VERY difficult for a underdeveloped brain to manage.
With cases like this, I think psychedelic treatment should be seriously considered. I wish it was something presented to us years ago, as I think she might have given it a go. A good rattle to the brain might give them a perspective they've never felt before. If this country were smart, we would pour a lot of money into research for this.