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Dontshootrude

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Everything posted by Dontshootrude

  1. The UK public health system has been a wealth of information throughout the pandemic. I've been extremely impressed with them. Today they published an in depth breakdown of the breakthrough cases that resulted in death among their population. Main points: Table 1 is really interesting, and shows how important the second shot is. Other interesting things to note: The fully vaccinated COVID deaths have a median age two years older than the unvaccinated (84 vs 82) and looking at the numbers compared to the unvaccinated, we are talking about very few people relative to the overall population. 98.8% of their COVID deaths are either unvaccinated or not fully vaccinated. It is remarkable how well the vaccines are working.
  2. I have had the Koda 16 for a year now and just converted mine to natural gas this weekend. I love it.
  3. Yep. Their decision to separate the shots by an extra week and tripling the amount of mRNA seems to be really paying off. That said, I got Pfizer in January and I'm still not seeking out a booster. In my age group it is still working fine.
  4. I'm listening to this podcast right now and I read the book. Given this is how I make a living it is really hitting home to me. CSB warning: Around 2014 Theranos sent a couple of representatives to our lab to "evaluate" their technology. They met us in one of our conference rooms, made us sign NDAs and passed around notebooks supposedly outlining their technology. We flipped through it and listened to their spiel. Afterwards we said "That all sounds great, but where is your data? I don't see anything in your presentation materials that remotely supports the claims you are making. You are welcome to come back with data, or more ideally loan us one of your machines for us to evaluate ourselves then we can talk endorsement and sales." We never heard from them again. She deserves to do real jail time.
  5. I'm curious to give this a try too. Next time I pick up a couple of flank/flatiron/hanger steaks I'll reserve one for this and report back.
  6. Give clarified butter a try as a comparison. That's my go to.
  7. An interesting MMWR was published Friday looking more specifically at the efficacy at the big three vaccines against hospitalization/severe disease against Delta and stratified the results by age. TL;DR: Efficacy against severe disease for all three vaccines is holding up well for those under 75, but there is increasing evidence that those 75 and older will benefit from getting a booster. https://www.cdc.gov/mmwr/volumes/70/wr/mm7037e2.htm?s_cid=mm7037e2_w#T1_down
  8. https://twitter.com/FTBVids_YT/status/1436901258116288512?s=20
  9. https://twitter.com/FTBVids_YT/status/1436901258116288512?s=20
  10. LMAO FSU
  11. Thompson showing some heart there!
  12. Jesus Christ. They don't call a targeting and now we can't even punch it in from the one.
  13. No question he earned it tonight.
  14. 2016 is going to be hard to top.
  15. Sums it up. Move him to #1 on the depth chart.
  16. This is the subject of multiple studies right now. Preliminary evidence out of the UK suggests that mixing and matching the different technologies (mRNA [Pfizer, Moderna], adenovirus vector [J&J, Astrazeneca], and subunit vaccines [Novavax]) might drive a better and longer lasting immune response compared to sticking with one company. This makes a lot of sense because the different technologies are going to stimulate different cell signaling pathways. For example, mRNA mechanisms are better at stimulating the B-cell driven antibody response whereas the adenovirus vector vaccines are going to do a better job at building cellular (T cell) immunity. It probably won't hurt you (we don't have large controlled trials to be sure), but I don't think you will really benefit much. Right, I'm not against boosters, but breakthrough cases are not the metric I'm looking at. The outcome of those cases is the key metric. As long as the vaccine is preventing severe disease (which it is) I don't see much reason to get a booster. And as I've outlined in prior posts there might be advantages to waiting and see how more experiments and trials play out before deciding when to get boosted and which shot to take. There is precedent for using infection outcomes rather than infections themselves in our recommended vaccine schedule. Pertussis (whooping cough) used to kill thousands of infants. In the 1930's a vaccine was developed by killing whole pertussis cells and injecting them into people. It worked well, but because of toxins normally found in the bacteria that were not affected by the inactivation, a small number of people had significant side effects after vaccination. This lead to the development of the modern day Pertussis vaccine, the acellular Pertussis vaccine (aP), which is found in the combination TDaP and DTaP vaccines. This vaccine injects a small amount of the actual protein responsible for all the horrible symptoms of whooping cough, thereby programming your immune system to essentially convert Pertussis from whooping cough into an asymptomatic bacteria that can live in your respiratory tract. Recent studies have shown that people (and monkeys) can transmit Pertussis, and might even be able to transmit it more easily than an unvaccinated person because they have no idea they are sick. This is why the Pertussis vaccine schedule is so aggressive, particularly in infants. They get shots at 2, 4, 6, 15 months, another one at age 4, and then intermittently from then on out and in pregnant women. This aggressive schedule, combined with antibiotics, are the reasons whooping cough deaths have remained incredibly low.
  17. Good post. To add to this, you need to look at the data on a more granular level. Those that get vaccinated and die are usually older and have significantly more risk factors than their unvaccinated counterparts. This isn't happening in healthy populations. https://www.sciencedirect.com/science/article/pii/S1201971221006391 https://www.sciencedirect.com/science/article/pii/S1198743X21003670?casa_token=QHZFcwIxbkoAAAAA:H-3DziM-WVQ15B8vmvnh880fhYJIndOQBVihSs1NmJKqH40oQ05asC7s6Tn6AjhF-rzqaXK2tw
  18. You can have memory B and T cells. There hopefully will also be these things called long lived plasma cells generated after vaccination. These are B cells that hang out in your bone marrow and secret antibodies continuously. If we are still detecting antibodies in vaccinated individuals years from now that will indicate that they are present, and will be a very good sign for long term immunity post vaccination. We have encouraging preliminary data that this may be occurring.
  19. Crush the pandemic = widespread immunity such that our healthcare system is no longer in danger of being swamped with cases and COVID becomes the next cold virus. You are right that it will be here forever, but once it isn't able to cause a significant amount of severe disease it is no longer an emergency.
  20. In some cases. But it would convert a lot of people. Money talks. I have a buddy who owns a business that works with high risk people. He wanted his entire staff fully vaccinated for multiple reasons. There were a lot of hold outs and some very heated exchanges when he announced that he was considering making vaccination a condition of employment. He later offered everyone in the company $200 in their next paycheck after they could prove they were fully vaccinated. His entire staff was vaccinated 5 weeks later.
  21. I don't typically frequent the cloak room, even when I was much more active in this community back when it was on the old scat board. My personal opinion is that in order to get our vaccination rates jacked up while avoiding a lot of violence we need another round of stimulus that is tied to your vaccination status. If everyone got $500+ for every household member that can prove vaccination I think you'd see a lot of hesitancy disappear overnight. We've spent so much money, what's another couple hundred billion to fully crush the pandemic and get our economy back on track?
  22. I anticipate the vaccination rates in young kids will be remarkably low unfortunately. Check out the rates in the 12-18 age group.....it is depressing.
  23. Ultimately the "vaccine violent" (great term!) are all going to get it and develop immunity via the high risk route. Eventually this will end, and COVID won't be a danger to our healthcare system. It is what it is. I'm not really concerned about these people on an individual level, particularly once the danger to our overall healthcare system has passed. It is a classic example of "play stupid games win stupid prizes."
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