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Anastasis

Certifiably Surly
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Everything posted by Anastasis

  1. Good to see you never get tired of debasing yourself. Here's a clip you guys might be interested in.
  2. Thanks for blessing us with your facebook feed.
  3. It was Okie MWM. The OK base will eat that up. Charlie Kirk strongly identified as a Christian. He was not killed for it. He was killed because he engaged people in the public square, put his shit out there and gave others equal opportunity to put their shit out there. Our political climate doesn't like that sort of thing.
  4. This is not reality based.
  5. Looks like a suppressed hunting rifle.
  6. Aint shit for a good hunting rifle. The shot was also off. He was either aiming for the head shot or the chest and got lucky with a neck shot in the jugular.
  7. That would be the right angle. They will have surveillance video from somewhere around campus.
  8. This is why the simulation demands it.
  9. Whatever words were coming out of his mouth at the moment had zero to do with the timing. Too many other more important moving parts in play.
  10. Yep. The close up of the neck shot looks straight jugular. He's dead.
  11. Maybe better to say it's gonna get to be more popping.
  12. This shit is about to pop the fuck off.
  13. That's a neck shot and he is dead. If that was a deer it wouldn't make it 20 yds.
  14. I would prefer an outright ban on DTC, but the argument is that that would trigger cases on 1st Amendment grounds. The ads are already mostly a recitation of adverse effects. I guess if you force them to read the whole package insert you could make the ads cost prohibitive and more annoying than they already are, but this doesn't get rid of them. The social media component is also a good area that needs some cleaning up. I don't have much hope that this actually does anything useful until we see actual enforcement and some skull cracking.
  15. And certainly in a heavily regulated space like pharma/healthcare. I've lost far more money in small biotech than I have ever made. I swore them off for a while. Well shit, I guess it was.
  16. Re: IBRX, this release today. Positive phase 2 data in lung cancer, let's land a phase 3. ImmunityBio’s ANKTIVA® Reverses Lymphopenia and Extends Overall Survival in Patients With Advanced Non-Small Cell Lung Cancer Resistant to Checkpoint Therapy September 8, 2025 PDF Version Severe lymphopenia, an adverse treatment effect associated with chemotherapy, radiotherapy, and immunotherapy, significantly lowers overall survival in non-small cell lung cancer and multiple types of cancer.1,2 With ANKTIVA, the first FDA-approved lymphocyte-stimulating agent, 80% of patients exceeded or maintained absolute lymphocyte count (ALC) above 1,000 cells/µL. With ALC counts greater than 1,500 cells/µL, statistically significant prolonged median overall survival (OS) of 21.1 months occurred with patients alive ranging as long as over 4 years in stark contrast to the historical 7 to 9 months survival with docetaxel in these patients with advanced lung cancer. Findings from the Phase 2 QUILT-3.055 study presented at IASLC 2025 World Conference on Lung Cancer in Barcelona, Spain represent a paradigm change in a chemotherapy-free treatment of lung cancer by activating Natural Killer cells and T cells, the lymphocytes key to inducing cancer cell death. Patients are currently being enrolled in the randomized Phase 3 ResQ201A trial (NCT06745908), which is evaluating ANKTIVA + tislelizumab, a checkpoint inhibitor versus docetaxel alone in second-line NSCLC patients who have progressed after all standard therapies, including checkpoint inhibitors.
  17. *laughs in drone strikes*
  18. Anastasis

    Austin FC

    What is this ref doing. Stuve credited for 2 pts.
  19. They are using the 2001 AUMF as cover for this shit. Are we ever gonna fn learn.
  20. His buddies at Mt Sinai and TH Chan. Shit they are regretting that paper at this moment, and probably looking for ways to walk it back. Or angling for the gov grant funding, more likely. Nothing like that tit.
  21. Not sure I learned and certainly don't recall the specific MOA either. NSAIDs of course, and CoxII's. Fn Merck man.
  22. Oh, and if this is type of stuff they are talking about in the Sept big reveal, it is as I expected. No new novel data, or studies. It's not even meta analytic work, just a lit review. Should not move the needle in a substantive way at all. Maybe they announce funding for studies, but certainly not landing anything substantive.
  23. Seems like there has been an ongoing line of inquiry into APAP exposure and neurodevelopmental issues. Wasn't something I was aware of at all. Here is a systematic review published last month. Lead author from Mt Sinai, senior author from Harvard TH Chan: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 Man, that's a epi challenge. You will never get a definitive answer. Exposure misclassification (OTC drug), impossible to assess all the potential confounders, outcome potentially influenced by variety of genetic and environmental exposures, unethical to do RCT work. The swedish study cited up thread is included in the review, and discussed in some detail in the discussion section. Even if you see an association, you are never gonna pull the drug...guidance will be as it is in current state...minimize dose and duration as indicated. Results We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis. Conclusions Our analyses using the Navigation Guide thus support evidence consistent with an association between acetaminophen exposure during pregnancy and increased incidence of NDDs. Appropriate and immediate steps should be taken to advise pregnant women to limit acetaminophen consumption to protect their offspring’s neurodevelopment.
  24. Wait. Who is getting sued? The WSJ?
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