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Anastasis

Certifiably Surly
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Everything posted by Anastasis

  1. Anastasis

    LBGTQ

    I was responding to someone calling me a piece of shit for posting "UK made a pretty easy evidence based decision. It was discussed on this thread months ago, but the US medical establishment has gone rogue." Yeah, your response is only making his point more clear.
  2. Joe flooded the zone with the numbers.
  3. Anastasis

    LBGTQ

    Just leave the kids alone please.
  4. Imagine getting lectures on how to internet from the guy that fills out a spreadsheet every time he walks into whatever corn based poverty grocery store predominates
  5. Anastasis

    LBGTQ

    UK made a pretty easy evidence based decision. It was discussed on this thread months ago, but the US medical establishment has gone rogue.
  6. Clowning in the USA.
  7. This board is hilarious.
  8. You are generally a kind and empathetic soul westside. Your posts upthread on this topic have been out of character. There may be some thing loaded on to that. Think on it.
  9. Kinda funny watching a bunch of people with state issued licenses in law and architecture and what not, with wives and kids and real responsibilities, argue with the hard rock cafe waiter. He doesn't understand you and you don't understand him.
  10. Cha ching?
  11. The OG label included wording that suggested the contin formulation was associated with lower abuse potential. Which was total bullshit, esp once you took one of those high dose tablets and crushed it to destroy the delivery mechanism. You went from having oxycodone tablets with 5-10mg of oxy to tablets with 80mg and eventually 160mg floating the market and kids starting dying. Fun fact, it was one of the pharmacy professors at UT that formulated the v2 delivery system that actually addressed this problem. Wonder how much UT pocketed off that patent.
  12. Annual sales. Oxycontin's approval by the FDA was a clear example of regulatory capture and the obvious problem with a revolving door between industry and the FDA. Purdue wrote the fucking approval letter in a hotel room with the FDA reviewer and without a compliance officer present. The FDA does a lot of really good work, but man when they shit the bed they really shit the bed.
  13. You probably experience this as a provider more than many, but the resultant backlash on the use of opiates, directly related to the opioid epidemic created primarily by Purdue, has cause untold amount of needless pain and suffering by patients.
  14. Just one time frame, but from 1996 to 2000 sales of Oxycontin went from 50MM to over 1B. The core drug entity had been around forever, was cheap and generic.
  15. Quigley advocates nationalizing the pharmaceutical industry and seizing their assets. I got lots of problems with the patent system as it relates to drugs. @TwiceHorn and I have had a few different exchanges on the subject with specific case examples discussed. I don't think that nationalizing the system is the right answer. I think that there are ways to get there by closing some of the more egregious loopholes that are taken advantage of by the pharmaceutical industry, and ensuring that the incentive structure promotes innovation instead of treadmilling. But if you want to make a run at the government seizing the industry's assets, go for it. If you can clear the political and legal viability hurdles of such, we can assess the outcomes of that move a decade or two out. I am not sure what the results will be, but I am quite certain that a bunch of lawyers will print coin in the process.
  16. If we COULD power clinical drug innovation off cliches alone, we could run the whole drug development industry solely on the output of a few posters in this thread.
  17. User fees are not necessarily a bad thing imo, but the FDA and Pharma are far too intertwined. Revolving door and all.
  18. The government is really good at subsidizing weapons programs, we should all be able to grant them that one. You seen the last Pentagon audit?
  19. Here's a new one. A Tajine. tenderloin and backstrap, browned. one onion, chopped can of chickpeas, rinsed. salt, pepper, garlic powder bottle of spicy moroccan sauce: https://www.heb.com/product-detail/fischer-wieser-four-star-provisions-spicy-moroccan-sauce/3391543 sliced almonds and chopped dried orange (apricot would be better) juice of 2 lemons, cilantro served with white rice This had no real spicy heat, some ghost pepper sauce would be a nice add.
  20. Their system is effectively subsidized by the American taxpayer and the American consumer.
  21. I like innovation. Our system should acknowledge and reward innovation, esp when that innovation is made by individuals or entities that are taking on risk. Unfortunately, nobody has yet figured out a way to power meaningful and consistent innovation in the pharma space with rainbows and cliches.
  22. If you want to try to control US healthcare expenditures, which in turn would help to control premium pricing and also reduce the need for Rx utilization management, e.g. step therapies and/or prior auth, we need to start with Pharma. Twenty percent of NHE and there are some really simple common sense things that we could do to start to address, e.g. ban direct to consumer advertising, require cost-effectiveness analyses as part of the approval process, align the pricing of me-too drugs with their incremental benefit, remove some of the absolutely silly regulations that increase costs unnecessarily (e.g. HFA reformulation of inhalers, etc.). All that shit can be done before we start addressing the big issues like securing the investment returns of American taxpayers.
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