I guess it really depends on where both Wright and Rojo are as passers. We honestly don't know, so I'd think of it like this:
Unless Wright is a particularly more skilled passer, we're probably at an advantage with Rojo. Once we're relying on our 3+ string qb, the game plan should be run heavy. Rojo in as qb introduces more conflict for defending both the run and pass, which should open up more easy running and throwing lanes. In any event we should count on a stacked box, so if we want to rely on running we should add a new wrinkle to help create space.
If we feel solid about Wright as a passer, maybe you do go traditional. I'm just assuming that since Card has been anything but consistent throwing the ball and Wright has never even threatened to take the backup role, possibly we have some reservations about him throwing it around.
This is all assuming we need a one game fix for UTSA, also. If both Ewers and Card need to miss extended time, you probably start preparing whoever you need to operate the real offense. I'd just rather see Rojo leading a rush heavy attack for one game against UTSA than spend time trying to get Wright ready to run the full offense.