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PsychMike

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Everything posted by PsychMike

  1. Given this thread and your avatar, is there a thread where I can read some of your stories on this? (I know this thread is not the proper place) I saw that Galveston county had 5% yesterday. Does anyone remember how many days in a row this threshold should be met?
  2. Aw, shit, didn't see that you already posted.
  3. too slow
  4. Also, I think Louis Gohmert's mask had a role in Herman Cain's death.
  5. Ernst and Collins took the same advertising class I see. Political advertising has no class at all. Mays Gilliam. He's for Cancer!
  6. You forgot the Pay Per View aspect to help pay down our National Debt. "Get your tickets to Trumpacobra 2020!"
  7. Yes, CV safety. There's a section titled "Risks‐Benefits of Combining the 2 Drugs" in the article I linked above.
  8. I'm not going to try to copy/paste due to formatting issues, but here's a link to an interesting article discussing the putative MOA of HCQ +/- AZ, along with a Table summarizing evidence to date. It's quite interesting. Unfortunately it's only got two legs of the proverbial tripod (can't speak for Zn). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280673/
  9. FYI, when I took Drug Study Design during my PharmD coursework back in the early to mid 90's, the faculty was from McMaster University in Canada. Guyatt is the guru. There is a systematic approach to evaluating the base of evidence to inform practice. As has been mentioned here, sometimes you don't have good RCTs to inform practice. You do your best with extant data. If you are a well-trained clinician, you use your experience, intuition, and things you learned from pedagogic teachings to fill in the gaps. Now here's the thing. If you DO have good RCTs that point in one direction, but you want to bend towards a bias (wherever the bias comes from, ie cute sales rep), you deserve whatever malpractice suits and negativity headed your way...especially when your patients are harmed. All this said, in the absence of effective, curative medicines, there are numerous strategies clinicians must employ. There's no question that politics has entered the arena on this approach, which is unfortunate because some clinicians are still trying to do their best with what they have in front of them. Bottom line: multiple RCTs demontrated no benefit of HCQ, which outweighs the supportive evidence base, which consists of zero blinded, well-designed RCTs that I can find. If the scientific community can sort through everything learned thus far regarding HCQ, I have no issue with informing new strategies to be tested via adequately powered, well designed RCTs, although Anastasis make a good point about the competition between studies and the precious resource of how many eligible patients are proximal to qualified research sites.
  10. Level of evidence (LOE) Description Level I Evidence from a systematic review or meta-analysis of all relevant RCTs (randomized controlled trial) or evidence-based clinical practice guidelines based on systematic reviews of RCTs or three or more RCTs of good quality that have similar results. Level II Evidence obtained from at least one well-designed RCT (e.g. large multi-site RCT). Level III Evidence obtained from well-designed controlled trials without randomization (i.e. quasi-experimental). Level IV Evidence from well-designed case-control or cohort studies. Level V Evidence from systematic reviews of descriptive and qualitative studies (meta-synthesis). Level VI Evidence from a single descriptive or qualitative study. Level VII Evidence from the opinion of authorities and/or reports of expert committees.
  11. Agree. Also, if the medical community at large doesn't seem to do a good job of sorting out levels of evidence, how can we expect the lay public to do so? BTW, I'm not suggesting doctors don't understand levels of evidence, but rather it is common to see rampant disregard of evidence-based medicine based on bias or other factors (an example is the use of antidepressants in Bipolar I Depression). Take a look at this quote from Dr. Birx around the time the task force was rolled out: So I know that she is highly trained and I am sure she understands levels of evidence, but WTF? I have always hoped she was pressured into saying that, or that she just worded her sentence poorly and meant something else. Argumentum ad populem is a BS political tactic and should never be amplified by medical experts.
  12. LOL at her 2nd tweet!
  13. Ya know, I enjoyed the hell out of Reggie McNeal lighting up OU for 4 TDs, despite the fact that I can't stand the dude and that lame ass program that he played for. But I have no regrets enjoying the hell out of it.
  14. What kind of name is Yoho, anyway?
  15. Did they use the Fisher's exact test? There's always something fishy about stories like this where they get the test bass ackwards.
  16. Excellent name for the band that plays at his campaign events.
  17. You know the fucked up thing about this situation is not that your statements are true (they are), but that the TEA fucking admits it in their Planning Guidance document released on July 7, 2020: Oh, OK. Mitigation is the key, right? So...one of the few things we know about this virus is that the people who are spreading it the most are the asymptomatic ones. So how the fuck is this mitigation strategy going to work? Last I checked, most schools don't have a tricked-out, plutonium-fueled DeLorean to go back in time and remove the super spreaders from the rest of the kids. Am I over-reacting? I want my son to be in a classroom again, and he wants it more than I do, but neither of us want him there until we feel it is safe. For everyone.
  18. I wish I could remember where I saw some video report on the guy showing up to Comet (the location of Pizzagate), but at least here's a Tweet about it back when the news broke:
  19. I found this one to be fascinating. It should be a satisfactory primer. https://jurneywrites.wordpress.com/2020/04/17/pizzagate-and-the-research-that-nobody-wanted-to-do/
  20. He's a war hero and Sharon Stone's cousin. He can't lose.
  21. I remember when that pissant Dotard acolyte was interviewed when he tauted his own ability to understand the data better than Fauci. I will never suffer from hypotensive episodes as long as jerk off sycophants like this are running our country into the ground, it just shoots my blood pressure up higher than the DJIA on a day when record unemployment numbers are released. https://www.cnn.com/2020/04/06/opinions/peter-navarro-anthony-fauci-hydroxychloroquine-expertise-hemmer/index.html
  22. See, this type of human excrement is an example of how political hacks could cause a massive amount of unnecessary deaths/disability/human suffering. The assholes like this bitch that have cultivated the suspicion that vaccines are harmful were the reason that once "eradicated" diseases like smallpox made a comeback. Fuck her and the herd she eroded in on.
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