Funny, because it seems like a lot of my reading lately has gravitated toward religious discussion. I don't know this book or its central argument, but what I understand of Hitchens is that a large part of his outlook is that science and religion are incompatible. Here are a couple books I have really enjoyed lately which speak to that, and address some of Hitchens' arguments specifically:
Francis Collins' The Language of God
This is well written for an intelligent general audience and has the further benefit of being written by someone who, like CS Lewis in Mere Christianity, began from the atheist perspective. It makes some very interesting arguments from Collins' own experience with genetics, as well as addresses some more universal issues (literally). One thing that I find very refreshing is that he not only makes cogent arguments for the existence of God in opposition to atheism, but also spends a very significant amount of time calling out the anti-intellectualism and ignorance of fundamentalism and young Earth creationists for the damage that they do. Really great read IMO.
Stephen Barr's The Believing Scientist
I'm pretty sure it was someone on a previous iteration of Surly/Shaggy/Shitty/Whatever who turned me on to Barr's Modern Physics and Ancient Faith, which is a really outstanding book but can get very technical (especially if, like me, you have little understanding of particle physics or quantum theory beyond Schrödinger's Cat). This is a collection of essays which largely distill and shorten those arguments so that they can be digested in smaller bites. As such, it can get a little repetitive and can be a little superficial, but it's still a very interesting read. If you were to read this and like it, I'd strongly suggest following it with Modern Physics and Ancient Faith, where he fleshes out a lot of these concepts much more fully.
I just started in on a biographical novel about Pontius Pilate which looks to be good, but these might be more relevant to what you're talking about.
BTW, this is one of my favorite threads on the site. Thank y'all for all the contributions.