Everything posted by Nivek
-
Sub-Educated Cretins: The SEC screenshot mega-thread
Yes, was there another?
-
Texas -- a failed state
Neither are Christians.
-
The Leopards Eating Faces and Unlubed Dildo of Consequences Thread
I saw a pet in the grocery store. I wish it was legal to euthanize these people.
-
CR Los Angeles fires thread
Election was rigged. I’ve a cousin who said they wuz forced to stuff ballots, he even videotaped it with his google glasses.
-
The Leopards Eating Faces and Unlubed Dildo of Consequences Thread
Band name, lobo, and all that.
-
The Supremes
how much is Luigi's bail?
-
Can we talk about Zuckerberg?
sounds like you need a blinky envelope...
-
CEO of UHG Shot and Killed in NYC - WTF is wrong with you New York
Well, I think my example pushes the costs an order of magnitude higher. ~$7k is strictly for recouping the investment and research of $11 billion, assuming that is all purely company sponsored internally (cash) and not financed through debt/equity or offset by research grants. The cost of manufacturing should also be included but I have no idea where to even start with numbers here. But it does seem to indicate that if the costs per treatment were $80k/treatment than that would be pretty absurd in a vacuum. I suppose the question is the cost of failures (those never made it out of trial/research) and possibly offsetting costs for research into other diseases which have far fewer patients to spread the costs among. I simply do not know enough about this industry to give a credible and honest critique. But like you, I do suspect the industry which also gave us the opioid epidemic might not be so benevolent across the board.
-
This is who Steve Sarkisian is.
Just look at pre injury QE offense this year. Note the difference there too.
-
CEO of UHG Shot and Killed in NYC - WTF is wrong with you New York
I think the challenge with @chainsaw's approach is that it doesn't reflect the complexity of finance well enough. A better way would be to calculate the net present value and split the research costs across 10 years, add a discount rate (say 7%) and projected cashflow rate from the sale in years 10-30 (assuming patent protected and monopoly) and then a generic alternative for years 30-40. If you only generated $1 billion for years 10-30, and .5 billion for years 30-40, you end up with a total revenue of $25 billion on an $11 billion investment. However, the NPV is negative, meaning you will be in the hole about $2.5 billion. The IRR for this project is ~5%. So if the investors only required 5% return, then this is a coin flip of a project. Now this excludes the foreign markets were price controls and approvals will vary. In that case, those 4 million US souls will pay $26 billion over the course of 30 years of being on the market to company X, which works out to about $6500 (very quick and dirty estimate) per treatment. Assuming no new people get sick. No inflation is assumed as well. This is also overly simplistic, with numbers, strategy, and distribution of costs all pulled from a hat.
-
Can we talk about Zuckerberg?
The fucking guy's software was directly used by bad actors to create a genocidal event based on fake news John Pym style.
-
Русский корабль - иди нахуй
too many.
-
Southern CA Fires- Extreme Santa Ana Winds
As a geologist, the only surprise was how ignorant the people were that this would happen. It isn't and if situation. Nice to see someone offer to help us out. We should fuck them over.
-
CR Los Angeles fires thread
I am confused, I thought they were supposed to pull themselves up by their bootstraps and the most dangerous words were "I am from the government and I am here to help." Or was that different?
-
Skeleton Crew (Star Wars Disney+ show)
My guess is the The Acolyte seems to have caused Disney to shy away from spending money to advertise it, and so they are going to Solo/Firefly this series despite of the viewers enjoying it. If they were smart they would keep it going and let it build momentum, heck even release the first few episodes online for free on YouTube to help it get going. My daughter likes Time Bandits on Apple+, but they fucked that program over with zero advertising of its existence and we just accidentally stumbled upon it. So I heard it is not picked up for a second series.
-
2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN
Staff is pretty good, but might benefit from an OC to take on some of the responsibilities during the game or Sark can demote himself and hire a HC game manager? The prevent defense has failed all year for the past few years. Not sure why or how they thought that toss was the best option when they were at the half yard on second down. Wild cat it to Gibson or QB sneak? Run and I-formation and put in Collins as the back or to hit/push the RB/QB forward.
-
Gunnar Helm
Oh, I get that, I just think it is stupid. Right now, the penalty for intentionally hitting a someone late, out of bounds, or trying to injure someone is 15 yards, the same as a simple hand gesture. The first 3 are often not even called correctly or as consistently and they are way more fucking dangerous than a horn's down or a finger point.
-
Elon Musk: Nazi traitor piece of shit [Confirmed]
He isnt the functioning ceo of shit. All he does is steal credit from someone else’s work.
-
Gunnar Helm
In no way, shape, or form should a finger point = a late hit cheap shot.
-
The Leopards Eating Faces and Unlubed Dildo of Consequences Thread
I know quite a few diabetics that all voted for him. I hope they fucking raise the price of insulin 5x.
- 2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN
- 2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN
- 2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN
- 2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN
- 2025 Cotton Bowl: CFP SF - Texas vs. Ohio State - 6:30pm on ESPN