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PsychMike

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Everything posted by PsychMike

  1. My favorite moment from last night:
  2. Thanks for pointing that out and count me as another who hadn't heard about it. This is from that linked article: uh, what's going on with #4 here? I mean, I know he's "The Holder" but WTF? Couldn't even wait until he got home, or at least the locker room to whack it?
  3. Oh, yes, indeed we know Our players will find a way to go No matter what the man said And Moore is fine, for all we know For all we know, he's gonna roll That's what the man said So won't you listen to what the man said? He said All gas and no brakes, baby However I digress.
  4. x, F, F, x -- Lewandowsky, apparently
  5. What is the length of a turtle's dick?
  6. Before Mongone went on a ventilator, she sent Vereckey a very emotional text. "One of her last texts to me was, 'I was so dumb. I should have gotten vaccinated. It was my belief. I was worried, wanted to do more research. But I was wrong. I should have gotten vaccinated,'" Vereckey said. "It broke my heart because I just knew she was really, really sick." After Mongone got sick, she made sure her 17-year-old daughter got vaccinated, her friend said.
  7. Go on...
  8. LOL. Well, triple may not like this
  9. It's in press, I think. We know from past experience, she's going to plagiarize this: Of course, the Editor will change the picture on the cover and make a slight yet apt revision to the title:
  10. Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients Ioannis P Trougakos # 1, Evangelos Terpos # 2, Christina Zirou 3, Aimilia D Sklirou 4, Filia Apostolakou 5, Sentiljana Gumeni 4, Ioanna Charitaki 6, Eleni-Dimitra Papanagnou 4, Tina Bagratuni 6, Christine-Ivy Liacos 6, Andreas Scorilas 7, Eleni Korompoki 6, Ioannis Papassotiriou 5, Efstathios Kastritis 6, Meletios A Dimopoulos 4 Affiliations collapse Affiliations 1Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece. itrougakos@biol.uoa.gr. 2Department of Clinical Therapeutics, School of Medicine, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, Greece. eterpos@med.uoa.gr. 3Thoracic Diseases General Hospital Sotiria, Athens, Greece. 4Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece. 5Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, Greece. 6Department of Clinical Therapeutics, School of Medicine, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, Greece. 7Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece. #Contributed equally. PMID: 34420521 PMCID: PMC8380479 DOI: 10.1186/s12916-021-02090-6 Free PMC article Abstract Background: Coronavirus SARS-CoV-2, the causative agent of COVID-19, has caused a still evolving global pandemic. Given the worldwide vaccination campaign, the understanding of the vaccine-induced versus COVID-19-induced immunity will contribute to adjusting vaccine dosing strategies and speeding-up vaccination efforts. Methods: Anti-spike-RBD IgGs and neutralizing antibodies (NAbs) titers were measured in BNT162b2 mRNA vaccinated participants (n = 250); we also investigated humoral and cellular immune responses in vaccinated individuals (n = 21) of this cohort 5 months post-vaccination and assayed NAbs levels in COVID-19 hospitalized patients (n = 60) with moderate or severe disease, as well as in COVID-19 recovered patients (n = 34). Results: We found that one (boosting) dose of the BNT162b2 vaccine triggers robust immune (i.e., anti-spike-RBD IgGs and NAbs) responses in COVID-19 convalescent healthy recipients, while naïve recipients require both priming and boosting shots to acquire high antibody titers. Severe COVID-19 triggers an earlier and more intense (versus moderate disease) immune response in hospitalized patients; in all cases, however, antibody titers remain at high levels in COVID-19 recovered patients. Although virus infection promotes an earlier and more intense, versus priming vaccination, immune response, boosting vaccination induces antibody titers significantly higher and likely more durable versus COVID-19. In support, high anti-spike-RBD IgGs/NAbs titers along with spike (vaccine encoded antigen) specific T cell clones were found in the serum and peripheral blood mononuclear cells, respectively, of vaccinated individuals 5 months post-vaccination. Conclusions: These findings support vaccination efficacy, also suggesting that vaccination likely offers more protection than natural infection. Keywords: Anti-S-RBD IgGs; BNT162b2 vaccine; COVID-19; Neutralizing antibodies; SARS-CoV-2; Viral infection.
  11. Holy Shit, they have a TE named Jaeger Bull? Doomed!
  12. OMG, the post about Truffles the clown lady was just the chef's kiss of Schadenfreude!
  13. Well, I got the shit kicked out of me in Arkansas once.
  14. Interesting language...is it like 20% more? Because that'd still be 0. Seriously, I look forward to beating the hawg shit outta Arky, hopefully with Collins playing a role in it.
  15. He also jumped out a window with his dick in his hand I thought that was John Henry.
  16. "Well, I mean I don't really have to believe in this stuff, do I?" "No, no! Just...fucking tell everybody you believe in this shit. When they say 'the sun sucks,' go, 'Yeah, fuck the sun! I fuckin' hate it too! Long live the fuckin' beast!'"
  17. Don't remember seeing this on this thread...
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