This thread reminded me of law school when we had to go though all of the commerce clauses cases chronologically up through Gonzales v. Raich, which is a case worth reading for anyone interested in this issue. You dip into the case law and it becomes very clear that some conservatives (Rehnquist) actually do care about states' rights. Others (Scalia) care about it only up to the point where the consequences become politically unpalatable for them.
In this instance, there is an obvious interstate element -- certainly a lot more of an impact on interstate commerce than homegrown medical MJ, which was at stake in Raich. From a legal perspective, the Feds should probably be able to win the case. And rightly so. But that does not change the hypocrisy. We had many decades of conservatives bloviating about states being a laboratory for new ideas, a substantive 10th amendment, etc. They largely abandoned those principles when "states rights" stopped being code for protecting racists and started being code for states liberalizing MJ laws and trying to protect the environment.