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  2. It sounds like the plot to a Monty Python movie
  3. i’ve killed billions upon billions of babies with thoughts of railing Jessica Tarlov while she’s slandering the hell out of Trump. “Fuck me down like that fat piece of vomit Trump is fucking democracy, you thick dicked piece of liberal shit coonass! Bring it! Harder! Make me gurgle like Orange fuckface giving a speech! “ spoooooooooge…
  4. Boy we love our turnovers in bunches.
  5. PSU going with the interim coach after all this would be a massive fail. Still plenty of better options out there. I'd be calling Mullen, Campbell, hell even Gruden or Daboll
  6. State College or Tampa? Hartline will win at USF and be able to pick a job... Or he can go to PSU and get fired.
  7. NCST up 45-38 on OU at half. In Norman
  8. Here's the thrust of his memo wrt regulatory path moving forward. The path forward for CBER/OVRR/OBPV I want to outline a path forward. Our general approach in CBER will be to direct vaccine regulation towards evidence based medicine. This means: we will take swift action regarding this new safety concern, we will not be granting marketing authorization to vaccines in pregnant women based on unproven surrogate endpoints (any prior promises will be null and void), and we will demand pre-market randomized trials assessing clinical endpoints for most new products. Pneumonia vaccine makers will have to show their products reduce pneumonia (at least in the post-market setting), and not merely generate antibody titers. Immunogenicity will no longer be used to expand indicated populations — these populations should be included in premarket RCTs. We will revise the annual flu vaccine framework, which is an evidence-based catastrophe of low quality evidence, poor surrogate assays, and uncertain vaccine effectiveness measured in case-control studies with poor methods. We will re-appraise safety and be honest in vaccine labels. I look forward to hearing your thoughts on how to do this better. Additionally, at FDA, we have not been focused on understanding the benefits and harms of giving multiple vaccines at the same time. This is a concern shared by many Americans. The FDA’s standard has been to require randomized studies too small to draw any conclusions from — creating a false sense of efficacy and safety. OVRR and OBPV staff will be tasked with writing guidelines to reflect these changes, and the mission of CBER will change to reflect this worldview. Never again will the US FDA commissioner have to himself find deaths in children for staff to identify it. Vaccines will be treated like all other medication classes — no better or worse than AAV vectors, monoclonal antibodies, or anti-sense oligonucleotides. Insofar as vaccines have third party benefits, and many do, these will be judged just like drugs may have third party benefits — a person who takes an appropriate psychiatric medicine may be a better parent or spouse — but this requires data and cannot be assumed. I have seen no evidence that COVID-19 vaccines, which do not halt transmission, benefit third parties. I have no doubt that MMR vaccines do provide third party benefits when administered to high enough fractions of society. Having said this, I remain open to vigorous discussions and debate on these topics, as I have always been. I am open minded to modifications or alterations. As you can imagine, I believe these debates should be private, internal to FDA, until they are ready to be made public. I don’t endorse selective reporting of our meetings and documents. Some staff may not agree with these core principles and operating principles. Please submit your resignation letters to your supervisor and CC my deputy Katherine Szarama. For those who choose to remain in CBER, I look forward to working with you, learning from you, discussing with you, and interacting with you on our shared mission: to elevate vaccine science to 21st century evidence based medicine.
  9. What a tremendous talent. RIP
  10. Clearly Justin Wells has never read a single paragraph he’s written. I consider this confirmation that he uses voice to text.
  11. If it's going to selection based, then expand the field to 24 teams like FCS.
  12. My wife will empty a bottle of lotion, use the last bit of toothpaste. Because those pennies saved can go towards a pair of Kate Spade shoes.
  13. Not with that background image. Where is that? Yosemite?
  14. Meh. They're one of the worst shooting teams in the league.
  15. First time seeing Carter Jr for the Magic play but I've decided he's a total bitch
  16. I appreciate Bobby’s ongoing contribution to Texas athletics, but he looks like someone who just lost his trailer in a tornado and shouldn’t be in front of a camera.
  17. Not at all. You guys didn’t rape kids.
  18. Drinking left over beer in the office fridge because we need to make room for new beer that's been brought in for our holiday party. It's 4:53 and I'm already 2 bottles in.
  19. It has been there for two weeks. She just left today for a week in Texas, and it's still there.
  20. Haven't all live sporting events' ratings been sinking due to the many streaming options now available?
  21. I can't wait to see the insane way this piece of shit leaves LSU in the lurch in a couple of years. I still don't understand why schools keep hiring the biggest douchebag in sports.
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