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Posted
43 minutes ago, Anastasis said:

Interesting novel therapeutic, pan-flu antiviral, one dose last 28 weeks, covers N5H1, not dependent on strain selection, very high effectiveness in phase 2. 

https://www.cidara.com/news/cidara-therapeutics-announces-positive-topline-results-from-its-phase-2b-navigate-trial-evaluating-cd388-a-non-vaccine-preventative-of-seasonal-influenza/

 

Obviously we should rush to deploy a novel treatment rather than utilize proven, safe, and effective vaccines! 

Posted
7 minutes ago, Parliament said:

That’s great.  No sarcasm.  So let’s be allowed to take both.  Let’s not restrict traditional vax access to those of us who want to take them.

Agree. Tomorrow ACIP will likely recommend expanded access to Flublock, a recombinant flu vaccine. 

Posted
15 minutes ago, Anastasis said:

Agree. Tomorrow ACIP will likely recommend expanded access to Flublock, a recombinant flu vaccine. 

More good news.  And a conventional vax for this year’s flu strain?  And this year’s Covid strain?  And no impediments to either?

You understand our reticence.  

Posted
9 minutes ago, bolverk said:

Promise of Victory Over H.I.V. Fades as U.S. Withdraws Support
A new drug that gives almost complete protection against the virus was to be administered across Africa this year. Now, much of the funding for that effort is gone.

This was supposed to be a breakthrough year in the 44-year-long struggle against H.I.V.

Decades of research and investment produced new approaches to vaccines that were going into their first significant clinical trials.

The hunt for a cure was homing in on key mechanisms to block the virus, which can lurk dormant and near-untraceable in the body for years.

Most critically, a breakthrough preventive drug, lenacapavir, a twice-yearly injection that offers total protection from H.I.V., was to be rapidly rolled out across eastern and southern Africa. The main target: young women. About 300,000 of them were newly infected with the virus last year — half of all new infections worldwide.

Every one of these plans has been derailed by the Trump administration’s slashing of foreign assistance.

There is more potential than ever before to end the H.I.V. epidemic, scientists and public health experts say. But now, H.I.V. programs across Africa are scrambling to procure drugs that the United States once supplied, replace lost nurses and lab technicians, and restart shuttered programs to prevent new infections.

“We imagined we would be in a different world right now,” said Dr. Leila Mansoor, a senior research scientist at the Centre for the AIDS Program of Research in Durban, South Africa. She had planned to spend 2025 analyzing data from one H.I.V. prevention trial, preparing for another and tracking how lenacapavir was transforming the epidemic — alongside colleagues testing new vaccines and cure strategies.

“And instead we’re moving backwards at warp speed,” she said.

Already, there are fears that H.I.V. infection rates are rising in the hardest-hit countries, but there is no clear way to measure the damage because data collection was mostly reliant on the terminated U.S. funding. Stocks of prevention drugs once supplied by the U.S. are running out across Africa.

 

Counterpoint: AIDS afflicts the queers and the blacks.  Thus, any treatment for it is DEI, and we've banned DEI.

Seriously, across the board, we have a new national policy of "anything that - even just statistically - benefits a minority/out group more than good American white people, is DEI and must be banned." It extends to literally every public policy area - see, e.g., public health and the post above.  It's fucking jaw-dropping how awful and evil it is, but there we are.

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Posted
5 minutes ago, Brisketexan said:

Counterpoint: AIDS afflicts the queers and the blacks.  Thus, any treatment for it is DEI, and we've banned DEI.

Seriously, across the board, we have a new national policy of "anything that - even just statistically - benefits a minority/out group more than good American white people, is DEI and must be banned." It extends to literally every public policy area - see, e.g., public health and the post above.  It's fucking jaw-dropping how awful and evil it is, but there we are.

Not only that, but stupid as shit because infectious diseases don't recognize national borders, no matter how high a wall gets built.

9yhl9o.jpg 

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Posted
37 minutes ago, Anastasis said:

What the fuck are you talking about? Just clowning. 

I get it. You ignore anything and everything that points to obvious anti-science approach of our current administration. You're a pathetic hypocrite and I'll continue to point that out. 

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Posted
6 minutes ago, Dahobbs said:

I get it. You ignore anything and everything that points to obvious anti-science approach of our current administration. You're a pathetic hypocrite and I'll continue to point that out. 

I posted a link about a novel anti-viral to the covid influenza black death thread. You vomit on your shoes immediately and reflexively. People can read the thread for themselves. 

Posted
27 minutes ago, Parliament said:

More good news.  And a conventional vax for this year’s flu strain?  And this year’s Covid strain?  And no impediments to either?

You understand our reticence.  

It's all in the materials that I posted on last page. Flu strain selection took place months ago. Regarding COVID, looks like some CDC pushback on the decision to can the recommendation for pregnant women. Generally the safety and effectiveness data are well laid out. Some interesting data in the backup slides on diminished returns in terms of antibody production based on number of prior combined infections/vaccinations.  

Posted (edited)

First Q/A session streaming now. Basically methodology discussions at this point around how VE estimates are influenced by different aspects of study designs re: the observational data presented. 

eta: Safety section Q/A now, Malone chimes in for first time. First point is around transparency regarding details of the safety analyses that have been conducted. Reasonable request I guess, but pretty much a throw away. Second is a question related to the lot to lot variability and whether any of the safety analyses have assessed any relationship. Another series of questions from him later on expanding the safety surveillance to include immunological implications and assessment of longer-term effects. Malones line of questioning is hard to follow.  The MIT guy's as well. Discussion was all handled very well by the CDC reps and their SMEs.

eta2; COVID section over now. No votes scheduled. 

Edited by Anastasis
Posted
3 hours ago, bolverk said:

Promise of Victory Over H.I.V. Fades as U.S. Withdraws Support
A new drug that gives almost complete protection against the virus was to be administered across Africa this year. Now, much of the funding for that effort is gone.

This was supposed to be a breakthrough year in the 44-year-long struggle against H.I.V.

Decades of research and investment produced new approaches to vaccines that were going into their first significant clinical trials.

The hunt for a cure was homing in on key mechanisms to block the virus, which can lurk dormant and near-untraceable in the body for years.

Most critically, a breakthrough preventive drug, lenacapavir, a twice-yearly injection that offers total protection from H.I.V., was to be rapidly rolled out across eastern and southern Africa. The main target: young women. About 300,000 of them were newly infected with the virus last year — half of all new infections worldwide.

Every one of these plans has been derailed by the Trump administration’s slashing of foreign assistance.

There is more potential than ever before to end the H.I.V. epidemic, scientists and public health experts say. But now, H.I.V. programs across Africa are scrambling to procure drugs that the United States once supplied, replace lost nurses and lab technicians, and restart shuttered programs to prevent new infections.

“We imagined we would be in a different world right now,” said Dr. Leila Mansoor, a senior research scientist at the Centre for the AIDS Program of Research in Durban, South Africa. She had planned to spend 2025 analyzing data from one H.I.V. prevention trial, preparing for another and tracking how lenacapavir was transforming the epidemic — alongside colleagues testing new vaccines and cure strategies.

“And instead we’re moving backwards at warp speed,” she said.

Already, there are fears that H.I.V. infection rates are rising in the hardest-hit countries, but there is no clear way to measure the damage because data collection was mostly reliant on the terminated U.S. funding. Stocks of prevention drugs once supplied by the U.S. are running out across Africa.

 

I’m starting to wonder if dotard and his clown show are actually sent back in time to end the human race from advancing too much and keep the population in check. To bolverk’s point, even though they are ostensibly targeting minorities, diseases don’t give a fuck. Maybe this is all part of a plan. Or a simulation. 

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Posted
34 minutes ago, Hank_Hill said:

Should be fine

America spoke and decided conspiracy theories, anti-science, hatred towards brown people, being terrified of 1% of the population just trying to live their life, pure uncut nepotism and immature bullying is the new America way

 

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Posted (edited)

@Anastasis still thinks this is balanced science and not political bullshit. He still thinks there is nothing to see here and that this is a balanced panel.

https://arstechnica.com/health/2025/06/all-childhood-vaccines-in-question-after-first-meeting-of-rfk-jr-s-vaccine-panel/

All childhood vaccines in question after first meeting of RFK Jr.’s vaccine panel

Beth Mole – Jun 25, 2025 6:04 PM | 116

A federal vaccine panel entirely hand-selected by health secretary and anti-vaccine activist Robert F. Kennedy Jr. gathered for its first meeting Wednesday—and immediately announced that it would re-evaluate the entire childhood vaccination schedule, as well as the one for adults.

The meeting overall was packed with anti-vaccine talking points and arguments from the new panel members, confirming public health experts' fears that the once-revered panel is now critically corrupted and that Kennedy's controversial picks will only work to fulfill his long-standing anti-vaccine agenda.

Controversial committee

An hour before the meeting began, the American Academy of Pediatrics came out swinging against the new panel, saying that the panel's work is "no longer a credible process." The organization shunned the meeting, refusing to send a liaison to the panel's meeting, which it has done for decades.

"We won't lend our name or our expertise to a system that is being politicized at the expense of children's health," AAP President Susan Kressly said in a video posted on social media.

The panel in question, the Advisory Committee on Immunization Practices (ACIP), has for more than 60 years provided rigorous public scientific review, discussion, and trusted recommendations to the Centers for Disease Control and Prevention on how vaccines should be used in the US after they've earned approval from the Food and Drug Administration. The CDC typically adopts ACIP's recommendations, and once that happens, insurance providers are required to cover the cost of the recommended shots.

The system is highly regarded globally. But, on June 9, Kennedy unilaterally and summarily fired all 17 esteemed ACIP members and, two days later, replaced them with eight new people. Some have clear anti-vaccine views, others have controversial and contrarian public health views, and several have little to no expertise in the fields relevant to vaccines.

Last night, it came to light that one of the eight new appointees—Michael Ross, an obstetrics and gynecology physician—had withdrawn from the committee during a financial holdings review that ACIP members are required to complete before beginning work on the panel.

With the remaining seven new members, ACIP's two-day meeting began this morning, despite calls for it to be scrapped. The new ACIP chair, Martin Kulldorff, introduced himself by proudly relaying that he had refused to get vaccinated against COVID-19 and was fired from Harvard University as well as an ACIP working group in the past.

Childhood vaccines under attack

Kulldorff's first order of business was to announce a new working group to review the safety of vaccine schedules in their entirety, rather than the safety of individual vaccines. Kulldorff was echoing an anti-vaccine talking point that children today get too many vaccines.

"In addition to studying and evaluating individual vaccines, it is important to evaluate the cumulative effect of the recommended vaccine schedule," Kulldorff said. "This includes interaction effects between different vaccines, the total number of vaccines, cumulative amounts of vaccine ingredients, and the relative timing of different vaccines."

Although children get more vaccines now than they did in the past, modern vaccines are more efficient at training the immune system against pathogens, exposing them to fewer elements of germs (antigens) to generate protective immune responses. A handy explanation from Yale's School of Public Health notes that children under age 2 in the 1980s got vaccines against just seven diseases—but those vaccines targeted over 3,000 antigens. Today, children under age 2 get vaccines against 15 diseases—but those vaccines target just 180 antigens, asking much less of the immune system.

Further, the cumulative effect of vaccines is baked into testing. When new childhood vaccines are tested in clinical trials, the children participating in those trials are still able to get every other vaccine recommended for them—withholding proven vaccines from participants would be unethical. So, any vaccine safety and efficacy trial includes children who are getting the entire vaccine schedule in addition to the vaccine being tested, providing information on cumulative effects with every new addition.

Kulldorff also said that the panel will go after specific vaccines, including the hepatitis B vaccine, which is given to newborns. The AAP immediately hit back, calling this "unscientific and dangerous." AAP highlighted that the hepatitis B vaccine is safe and lifesaving. Babies infected with hepatitis B at birth have a 90 percent chance of developing chronic disease, and 25 percent with chronic infections will end up dying from it. Thanks to vaccination, there were only 13 cases of hepatitis B in 2022.

“Very concerned”

During the full-day meeting, the seven new members listened to CDC experts review data on COVID-19 vaccines and RSV vaccines and monoclonal antibodies. In the discussions, ACIP member Retsef Levi—who is an expert in operations management—made a puzzling critique that the CDC's method for evaluating COVID-19 vaccine efficacy analysis didn't account for "alternative" explanations like "the vaccine is actually making you more vulnerable for multiple viruses."

Meanwhile, ACIP member Robert Malone—who has claimed to have invented mRNA vaccines and is proud to be called an "anti-vaxxer"—spread false misinformation that certain lots of COVID-19 vaccines were dangerous. ACIP member Vicky Pebsworth—a nurse who is on the board of an anti-vaccine organization—said she was "very concerned" that the CDC's safety monitoring systems were not capturing all of the adverse events from vaccines and said the committee should have access to "data that we probably wouldn't ordinarily have." A CDC subject matter expert noted that there are published studies showing that the CDC's safety monitoring systems capture a large majority of adverse events.

The committee ran over time and did not vote on anything today. But tomorrow, it will vote on an RSV monoclonal antibody discussed today, as well as on influenza vaccines, which will be discussed on Thursday. The agenda also includes presentations on a measles vaccine that has been the target of anti-vaccine activists.

One presentation on flu shots will come from the former president of Kennedy's anti-vaccine organization, the Children's Health Defense. The slides of that presentation have been posted and will focus on the alleged dangers of a mercury-based preservative thimerosal, which anti-vaccine advocates have long falsely linked to autism. Already, researchers and media reports have noted that the presentation supports some of its claims with a study that does not exist.

Edited by Dahobbs
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Posted
1 hour ago, HenryJames said:

The dumbest fucking people.

Are going to convince a bunch of other dumb fucking people to harm their kids.

Might as well bring back polio, if it was good enough for FDR, it was good enough for our kids.

Posted
1 hour ago, atomheartbevo said:

Are going to convince a bunch of other dumb fucking people to harm their kids.

Might as well bring back polio, if it was good enough for FDR, it was good enough for our kids.

Polio will be back.  Mark it 0, dude.

  • Like 2
Posted

Got covid last Friday and am on my last dose of Paxlovid today. This new variant was all kinds of fucked up as the symptoms came in waves.  First was the extreme body aches early Friday morning (this was the biggest bitch of all. I still haven't had a full night's sleep since last Thursday due to all the tossing/ turning and hot showers), then came the fatigue later Friday, then congestion Saturday, which led to coughing a couple hours later, and finally, sore throat (almost strep- like) Saturday night. 2am Sunday morning comes around and I'm convinced death is near. I work up the strength to drive to urgent care because surely this "little cold" floating around the office shouldn't feel like this, right? Even the doc was all "well, we should test for flu and covid to be safe, but we haven't seen either floating around recently." 2 nasal swabs and 15 minutes later, and boom. Positive. 

 

I'm really hoping this flu season that covid shots won't be as stupid costly as they were last year, and even moreso, hope that insurance will cover it. First time since the vaccines came out that I didn't get a shot (I think I was told north of $450 and insurance wouldn't cover any of it) and it comes back to no lube me. 

/ rant

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Posted
3 hours ago, BigHorn'13 said:

First time since the vaccines came out that I didn't get a shot (I think I was told north of $450 and insurance wouldn't cover any of it) and it comes back to no lube me.

And this is why RFK was appointed.

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Posted
22 minutes ago, tokamak said:

Jesus that recap article is chilling. The trust destroyed here will take generations to build back.

Or never 

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Posted
14 hours ago, Js1 said:

America spoke and decided conspiracy theories, anti-science, hatred towards brown people, being terrified of 1% of the population just trying to live their life, pure uncut nepotism and immature bullying is the new America way

 

New? Bless your heart. 

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Posted
6 minutes ago, Deej said:

New? Bless your heart. 

All I know is, America will "course correct" in 2026/2028, followed by a boomerang back to American fascism in 2030/2032 because Democrats didn't fix everything in 1 term. 

That is the standard that the America media and "education" system and social media brain rot has put onto American voters - Democrats have to fix everything in 4 years or be punished harshly  Republicans can break everything and then be voted back in to break it again. 

 

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Posted
9 hours ago, Dahobbs said:

@Anastasis still thinks this is balanced science and not political bullshit. He still thinks there is nothing to see here and that this is a balanced panel.

 

Stop @ing me with an arstechnica piece and strawmanning. I listened to most of meeting in teh background yesterday and will do so today. I don't need your selected editorials. 

I do find it funny that you are now tuning into the political bullshit surrounding the CDC though. I think a lot of the RFK blowback wrt vaccine could have been avoided if people like you actually paid attention to the science instead of pushing mandates and public health initiatives based absurd immunology and the feeling that the best lever to pull was threatening people with their jobs. COVID was a mess and broke a lot of brains on this particular topic. And now your view on the science are hopelessly intertwined with politics. I remember the threads on the old board where there were fairly in-depth exchanges about things like the vaccine schedule, hep b at birth, timing of things like MMR for maximum effectiveness, etc. Posters here were generally less politically brain damaged back then and didn't act like clowns like you are doing. I also recall the reactions on the political board when Perry mandated the Gardasil thing for young girls. What a world, if you pay attention long enough.  

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Posted
7 hours ago, tigol said:

Polio will be back.  Mark it 0, dude.

Yep, it’s going to happen.  Maybe when dumbfucks see their kids lying in an iron lung, they’ll question things.  Or they’ll just blame wokeness.

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Posted
48 minutes ago, Anastasis said:

Stop @ing me with an arstechnica piece and strawmanning. I listened to most of meeting in teh background yesterday and will do so today. I don't need your selected editorials. 

I do find it funny that you are now tuning into the political bullshit surrounding the CDC though. I think a lot of the RFK blowback wrt vaccine could have been avoided if people like you actually paid attention to the science instead of pushing mandates and public health initiatives based absurd immunology and the feeling that the best lever to pull was threatening people with their jobs. COVID was a mess and broke a lot of brains on this particular topic. And now your view on the science are hopelessly intertwined with politics. I remember the threads on the old board where there were fairly in-depth exchanges about things like the vaccine schedule, hep b at birth, timing of things like MMR for maximum effectiveness, etc. Posters here were generally less politically brain damaged back then and didn't act like clowns like you are doing. I also recall the reactions on the political board when Perry mandated the Gardasil thing for young girls. What a world, if you pay attention long enough.  

See, you'll do deep dives into conspiracy theories surrounding Fauci and Covid, but can't even raise one bit of criticism to the clear anti-science bullshit being peddled. Fucking hypocrite. You're the brain damaged one. And you are smart enough to know better. 

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Posted
Yep, it’s going to happen.  Maybe when dumbfucks see their kids lying in an iron lung, they’ll question things.  Or they’ll just blame wokeness.

That’s the thing. When the Salk vaccine came out, you couldn’t keep parents away. Polio killed kids left and right seemingly with no end in sight and they lined their kids up with arms out. Some iterations DID have negative consequences, but compared to the virus you didn’t need critical thinking to understand the concept.
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Posted
12 minutes ago, kevwun said:

Yep, it’s going to happen.  Maybe when dumbfucks see their kids lying in an iron lung, they’ll question things.  Or they’ll just blame wokeness.

The second thing. Or the Democrats

Posted
24 minutes ago, tigol said:

That’s the thing. When the Salk vaccine came out, you couldn’t keep parents away. Polio killed kids left and right seemingly with no end in sight and they lined their kids up with arms out. Some iterations DID have negative consequences, but compared to the virus you didn’t need critical thinking to understand the concept.

What pisses me off about the anti-vaxxers is that some of the ones I know literally had relatives who were fucked up by things like Polio and measles. Not some distant cousin, but aunts and uncles.  Polio vaccine was in the 50s so we aren’t that far removed - middle-aged people grew up around relatives who had first-hand experience with this shit, and their parents made sure they were vaccinated.

Posted (edited)
31 minutes ago, Dahobbs said:

See, you'll do deep dives into conspiracy theories surrounding Fauci and Covid, but can't even raise one bit of criticism to the clear anti-science bullshit being peddled. Fucking hypocrite. You're the brain damaged one. And you are smart enough to know better. 

Speaking of deep dive, between you and me, I am the one that is watching the actual meeting you fucking clown. I am sorry if it hurts your feels what happened with the lab leak dialogue. But I guess quote me another arstechnica editorial. 

Edited by Anastasis
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Posted
36 minutes ago, Dahobbs said:

See, you'll do deep dives into conspiracy theories surrounding Fauci and Covid, but can't even raise one bit of criticism to the clear anti-science bullshit being peddled. Fucking hypocrite

 

5 minutes ago, Anastasis said:

Speaking of deep dive, between you and me, I am the one that is watching the actual meeting you fucking clown. I am sorry if it hurts your feels what happened with the lab leak dialogue. 

Ana is always a master class in complete deflection from the valid point being made. There is no force on earth that can get him to trash talk his orange hero’s administration.

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