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Posted
4 minutes ago, DalTxHornFan said:

Never, never, none.  Better if you don't stand too close to me!  (Seriously, I must have had it by now, but no symptoms that I recall.)

Same. Have nc seroconverted but never have tipped a positive test. 

Posted

I got the pfizer about a month ago. I've had both over the past years. I may have gone to sleep a little early that night. My wife got it about the same time and she was in bed for about 2 days but she has responded poorly to the vaccine before. 

Anyway, good news for those who've participated:

 

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Posted
16 hours ago, Chopper said:

I got the pfizer about a month ago. I've had both over the past years. I may have gone to sleep a little early that night. My wife got it about the same time and she was in bed for about 2 days but she has responded poorly to the vaccine before. 

Anyway, good news for those who've participated:

 

Even if you rule out any confounding or bias from the observational nature of the study and the demographics of a VA population, then you have to look at absolute risk reduction.

18.3 ER visits per 10,000

7.5 hospitalizations per 10,000

2.2 deaths per 10,000

This gives you a NNT (number needed to treat) or NNV of

546 to prevent one ER visit

1,333 to prevent one hospitalization

4,545 to prevent one death

We can go further into discussion, but these numbers appear to back up the current policy of 65 and up or with chronic health conditions getting the booster if they want. 

But I'm happy that you can all find it if you want.

Go on with your bad selves.

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Posted (edited)
33 minutes ago, Screwed said:

Even if you rule out any confounding or bias from the observational nature of the study and the demographics of a VA population, then you have to look at absolute risk reduction.

Look, I'm very pleased you selected a user name that reflects your lot in life. However, I'm saddened you don't understand the ramifications of getting covid. But have a good day, clown. Also I think there's a thread for nonces like you who want to have this argument. You should go there. 

Edited by Chopper
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Posted
12 minutes ago, Chopper said:

Look, I'm very pleased you selected a user name that reflects your lot in life. However, I'm saddened you don't understand the ramifications of getting covid. But have a good day, clown. Also I think there's a thread for nonces like you who want to have this argument. You should go there. 

Who's arguing anything? Just discussing the study you shared.

If you don't understand what I posted, maybe you don't know where the discussion should go?

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Posted
18 minutes ago, Chopper said:

Look, I'm very pleased you selected a user name that reflects your lot in life. However, I'm saddened you don't understand the ramifications of getting covid. But have a good day, clown. Also I think there's a thread for nonces like you who want to have this argument. You should go there. 

What you don't get is any risk comparison.  Which, you know, is the relevant way to evaluate risk.

What is your risk of contracting COVID and having a negative outcome, stairstepping up in levels of severity, if unvaccinated?

What is your risk of an adverse vaccine reaction, stairstepping up in levels of severity?

In other words, what is my illness risk reduction if vaccinated, and what is my adverse reaction risk increase if vaccinated - which is greater?

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Posted
5 minutes ago, Brisketexan said:

What you don't get is any risk comparison.  Which, you know, is the relevant way to evaluate risk.

What is your risk of contracting COVID and having a negative outcome, stairstepping up in levels of severity, if unvaccinated?

I've read the study. The absolute risk reduction numbers are in my previous post.

1 hour ago, Screwed said:

Even if you rule out any confounding or bias from the observational nature of the study and the demographics of a VA population, then you have to look at absolute risk reduction.

18.3 ER visits per 10,000

7.5 hospitalizations per 10,000

2.2 deaths per 10,000

This gives you a NNT (number needed to treat) or NNV of

546 to prevent one ER visit

1,333 to prevent one hospitalization

4,545 to prevent one death

 

6 minutes ago, Brisketexan said:

What is your risk of an adverse vaccine reaction, stairstepping up in levels of severity?

They did not look at adverse reactions in the study.

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Posted
1 minute ago, Screwed said:

I've read the study. The absolute risk reduction numbers are in my previous post.

 

They did not look at adverse reactions in the study.

Sure.  That would be another, different study.  Which would give rates.  Then compare rates.

If I have a 1 in 1,000 chance of dying of disease X, and I have a 1 in 10,000 chance of dying of an adverse vaccine reaction (assuming arguendo that "death" is the primary adverse event in either case), then the math dictates the smarter choice.

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Posted

Sincerely, it's great to see an observational study get published in NEJM. It's a pretty sophisticated analysis, and the VA has certain advantages wrt the data they collect. The limitations of an observational study, the constraints on generalizability, and the very modest absolute risk reduction have been discussed more than adequately up thread. But just to amplify the generalizability issue, mean age 71 years, over 90% male, obese on average. The results (esp some of the data in the supp appendix) strongly reinforce risk-based recommendations (age, comorbidities, etc.) rather than universal recommendations that include children, adolescents, and young healthy adults. 

 

It's amazing that instead of reviewing rounds of results from RCTs with each subsequent booster release we are digesting tweets related VA observational studies.  Hopefully the new FDA guidance incentivizes more of that kinda work.  

Posted
2 hours ago, SydneyCarton said:

Science has been debunked, sir. 

 

2 hours ago, jimmyjazz said:

They don't call it science fiction for no good reason.

“Science” is derived from an old Indo-European word that meant, “to do your own research online”.

Posted
3 hours ago, Deej said:

Are you really gonna believe science?

The heroin addict lawyer who got a fucking literal brain worm from eating raw monkey would have you believe in your opinion and not the experts.

That Bishop's response is pretty solid:

This is a classic textbook example of rhetorical confusion, an attempt to sound anti-authoritarian while misunderstanding both science and faith.

Science at its best depends on disciplined expertise, peer review, and humility before evidence. Trusting experts does not mean blind obedience; it means recognizing the limits of one’s knowledge and valuing rigorous, tested inquiry.

Rejecting expertise outright is not democratic; it is anti-intellectual. Democracies function when informed citizens weigh evidence responsibly, not when everyone treats opinion as equal to informed understanding.

The comparison to religion is equally misguided. Mature faith is not credulous submission but trust grounded in relationship, conscience, and reason. The Christian tradition affirms that faith seeks understanding. It wrestles with truth; it does not suspend thought.

Equating trust in credible expertise with totalitarianism is not only false but dangerous, because it erodes the trust that makes both science and democracy possible. Such rhetoric reveals a crisis of epistemic humility, characterized by an inability to acknowledge that truth requires both personal integrity and communal wisdom.

When distrust becomes an identity, the result is not freedom but fragmentation, where no one can learn from anyone else.

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Posted

Went to Walgreens, walked in and set up the flu and Covid vaccine.  When it asked me if I have any chronic illnesses, I checked the box that said "I don't know" and the system was like, Ok you're good to go.  God the flu shoot and the Pfizer vaccine.  Assuming my insurance will pay for it.  🤞🤞🤞

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  • 2 weeks later...
Posted

COVID-19 mRNA vaccines can trigger the immune system to recognize and kill cancer, research finds
The researchers found that mRNA-based COVID-19 vaccines could potentially help patients whose tumors don’t respond well to traditional immunotherapy.

The COVID-19 mRNA-based vaccines that saved 2.5 million lives globally during the pandemic could help spark the immune system to fight cancer. This is the surprising takeaway of a new study that we and our colleagues published in the journal Nature.

While developing mRNA vaccines for patients with brain tumors in 2016, our team, led by pediatric oncologist Elias Sayour, discovered that mRNA can train immune systems to kill tumors — even if the mRNA is not related to cancer.

Based on this finding, we hypothesized that mRNA vaccines designed to target the SARS-CoV-2 virus that causes COVID-19 might also have antitumor effects.

So we looked at clinical outcomes for more than 1,000 late-stage melanoma and lung cancer patients treated with a type of immunotherapy called immune checkpoint inhibitors. This treatment is a common approach doctors use to train the immune system to kill cancer. It does this by blocking a protein that tumor cells make to turn off immune cells, enabling the immune system to continue killing cancer.

Remarkably, patients who received either the Pfizer or Moderna mRNA-based COVID-19 vaccine within 100 days of starting immunotherapy were more than twice as likely to be alive after three years compared with those who didn't receive either vaccine. Surprisingly, patients with tumors that don't typically respond well to immunotherapy also saw very strong benefits, with nearly fivefold improvement in three-year overall survival. This link between improved survival and receiving a COVID-19 mRNA vaccine remained strong even after we controlled for factors like disease severity and co-occurring conditions.

To understand the underlying mechanism, we turned to animal models. We found that COVID-19 mRNA vaccines act like an alarm, triggering the body's immune system to recognize and kill tumor cells and overcome the cancer's ability to turn off immune cells. When combined, vaccines and immune checkpoint inhibitors coordinate to unleash the full power of the immune system to kill cancer cells.

 

Why it matters
Immunotherapy with immune checkpoint inhibitors has revolutionized cancer treatment over the past decade by producing cures in many patients who were previously considered incurable. However, these therapies are ineffective in patients with "cold" tumors that successfully evade immune detection.

Our findings suggest that mRNA vaccines may provide just the spark the immune system needs to turn these "cold" tumors "hot." If validated in our upcoming clinical trial, our hope is that this widely available, low-cost intervention could extend the benefits of immunotherapy to millions of patients who otherwise would not benefit from this therapy.

What other research is being done
Unlike vaccines for infectious diseases, which are used to prevent an infection, therapeutic cancer vaccines are used to help train the immune systems of cancer patients to better fight tumors.

We and many others are currently working hard to make personalized mRNA vaccines for patients with cancer. This involves taking a small sample of a patient's tumor and using machine learning algorithms to predict which proteins in the tumor would be the best targets for a vaccine. However, this approach can be costly and difficult to manufacture.

In contrast, COVID-19 mRNA vaccines do not need to be personalized, are already widely available at low or no cost around the globe, and could be administered at any time during a patient's treatment. Our findings that COVID-19 mRNA vaccines have substantial antitumor effects bring hope that they could help extend the anti-cancer benefits of mRNA vaccines to all.

What's next
In pursuit of this goal, we are preparing to test this treatment strategy in patients with a nationwide clinical trial in people with lung cancer. People receiving an immune checkpoint inhibitor will be randomized to either receive a COVID-19 mRNA vaccine during treatment or not.

This study will tell us whether COVID-19 mRNA vaccines should be included as part of the standard of care for patients receiving an immune checkpoint inhibitor. Ultimately, we hope that this approach will help many patients who are treated with immune therapy, and especially those who currently lack effective treatment options.

This work exemplifies how a tool born from a global pandemic may provide a new weapon against cancer and rapidly extend the benefits of existing treatments to millions of patients. By harnessing a familiar vaccine in a new way, we hope to extend the lifesaving benefits of immunotherapy to cancer patients who were previously left behind.

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Posted

This could go in a lot of places, but our AG needs a new distraction and some red meat to throw to the *checks notes* batshit conspiracy types, so Texas is suing Tylenol because autism and ADHD.

Probably in Tyler, Texas.

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  • Rage+1 2
Posted

This fucking piece of shit state...

This is what happens when absolute fucking idiots run the asylum, and then have absolute fucking idiots keep voting for them regardless of the absolute idiot shit that they do.

Next we're going to sue little league baseball and soccer associations for causing an elevated risk for skin cancer.

“Children's soccer and baseball organizations betrayed America by profiting off of fun and forcing kids be in the sun regardless of the risks," Paxton said in a statement on Tuesday. "These organizations lied for decades, knowingly endangering millions to line their pockets. ... By holding somebody/anybody accountable for poisoning our children's skin, we will help Make America Healthy Again.”

 

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Posted (edited)
6 hours ago, atomheartbevo said:

This could go in a lot of places, but our AG needs a new distraction and some red meat to throw to the *checks notes* batshit conspiracy types, so Texas is suing Tylenol because autism and ADHD.

Probably in Tyler, Texas.

G4WUHLva0AAhRdH?format=jpg&name=large

How can any Texan take this piece of shit seriously?  I don't care what your political beliefs are, every Texan should be able to spot a bullshit artist that is this obvious, right?  Right‽‽‽ 

Edited by Samson's Wig
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Posted

2025 you wild'n

https://www.actionnews5.com/2025/10/28/truck-hauling-aggressive-monkeys-carrying-herpes-covid-overturns-mississippi/

Authorities said the driver of the truck carrying the monkeys told law enforcement that the monkeys “were dangerous” and “posed a threat to humans.”

Authorities say they took the appropriate actions after being given that information.

The Jasper County Sheriff’s Office said all of the escaped monkeys, except for one, “have been destroyed.”

The sheriff’s department is still looking for one of the monkeys that is still on the loose.

Posted
32 minutes ago, Captainant said:

2025 you wild'n

https://www.actionnews5.com/2025/10/28/truck-hauling-aggressive-monkeys-carrying-herpes-covid-overturns-mississippi/

Authorities said the driver of the truck carrying the monkeys told law enforcement that the monkeys “were dangerous” and “posed a threat to humans.”

Authorities say they took the appropriate actions after being given that information.

The Jasper County Sheriff’s Office said all of the escaped monkeys, except for one, “have been destroyed.”

The sheriff’s department is still looking for one of the monkeys that is still on the loose.

Mississippi becomes infested with diseased monkeys.

Public health in Mississippi improves by 30%.

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