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why wouldn't anyone ever buy generic drugs?

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Not even talking about critical, life saving shit, like Viagra.  But OTC stuff like Sudafed, Mucinex, Afren, whatthefuck ever.

 

They're sitting side by side with the other stuff, clearly labeled and illustrated and explicitly said to be a counterpart to the other stuff, with same exact active ingredient in the same concentration, but cost say $10 vs $15.  

 

It isn't like Dr Pepper vs Professor Pfeiffer where you sip the motherfucker and there's a component of subjectivity.  It's a pill.

 

Why would anybody pay more for the other stuff?

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Some generics are formulated that they release at different rates than the branded equivalent.  For a lot of drugs this isn't a big deal, but for some, it could be.

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"Generic" in the drug or pharmaceutical context has at least a couple of meanings.

In it's simplest form, it means a drug without a brand name, usually similar or identical in formulation. We'll call this "g" generic.

In prescription drugs, it gets more complicated.  At the start of FDA approval, most or many prescription drugs are still protected by patents.  Whether patented or not, a newly approved drug will receive five years of exclusivity.  And of course it is given a fancy new name.

When exclusivity expires, whether the five-year term or the seven-year term for orphan drugs, and any patent expires, another manufacturer may apply to make the drug (chemically and pharmacogically identical in theory), and, if granted permission can then make a GENERIC drug.  So in that sense, generic means not only not "name brand," but also unpatented and unprotected by FDA exclusivity.  We'll call this "G" Generic.

There could be small differences in generic drugs that might affect their effectiveness.

There shouldn't be any difference in Generic drugs because they are necessarily made to a "specification" because of FDA approval.  But there are reports that there are.

I buy the cheapest generic shit I can find, which is usually the grocery-store brand, but I check the label to see that it has the same shit in the same amounts as the brand name stuff.  The *Tussin DM is a go-to, also *Dryl (benadryl).

 

Edited by TwiceHorn

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all I got is acetylsalicylic acid, generic. See, I can get six hundred tablets of that for the same price as three hundred of a name brand. That makes good financial sense, good advice

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I always buy the HEB version of Zyrtec.  I can get 120 tablets of the HEB brand for the price of 36 Zyrtec or something like that.

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i had a GF who's family had the same family doctor for decades.  He was in his 70's when she was college age.  He stamped every RX with "No Generics".  Once I had to fill a prescription for her, and I was wondering WTF is the bullshit.  I asked her mom about it later, and she gave me a spiel that he had given her about how pharm companies deserved their profits for their drugs, bla bla bla.   I'm like, it's fucking penicillin?

FWIW, the family lawyer (and longtime friend) was Bill Dannemeyer, so y'all can draw your own conclusions about how nuts they were. 

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My wife and every other doctor or pharmacist I know has no problem using generic drugs, OTC or Rx. And yes, I ask every single one of them this question at parties or dinners. 

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N-Nitroso-N-methyl-4-aminobutyric acid is a good reason NOT to buy generic.

That's the cancer causing contaminant that keeps getting into generic blood pressure medications causing them to be recalled.   

I asked my pharmacist how much the Name Brand was... he pretty much laughed at me. Seems Merck stopped production when their patent ran out. 

Today there are only generics and almost all of them are made by shitty companies from India. 

 

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12 hours ago, Iceman said:

This fits in right here...

 

I digress, but that man was a fucking genius.....

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I used to work for a generic drug manufacturer. I also used to work for a name brand, who not only made their own generic brand but also did contract manufacturing for store brands for their non patented products. Would make a big batch, fill some in their boxes/labels, then some with Walgreens, then some with Albertsons, target, etc. 

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I barely trust quality control in the name brand drug companies, I sure as shit don’t trust the QC on vendors that Wal-Mart, CVS etc would have on their “private label” shit. 
 

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14 minutes ago, BrazilHorn said:

I barely trust quality control in the name brand drug companies, I sure as shit don’t trust the QC on vendors that Wal-Mart, CVS etc would have on their “private label” shit. 
 

Oddly enough, that seems more of an issue with prescribed Generics than OTC.  Perrigo makes a lot of private label stuff and I have had zero problems with it.

Edited by TwiceHorn

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2 hours ago, NeverMarryAStripper said:

I only buy generic Viagra

And there would be no problem with that, except for the fact that your prescription was for Levothyroxin.

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On 2/12/2020 at 4:29 PM, Whitman said:

Some generics are formulated that they release at different rates than the branded equivalent.  For a lot of drugs this isn't a big deal, but for some, it could be.

Not remotely true.

 

Quote

Fuck big Pharma and their BULLSHIT.

One of the biggest scams in the country.

 

 

 

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I had a doctor once tell me generics only have to hit 80% equivalent dosage - meaning they can be off of a 10mg dose by 2mg or so.  Name brands don't do that.

That makes no sense to me but he was absolutely all "they've done tests you know" and all that.

I have personally found that nonprescription generics vary.  Some are indistinguishable.  Some seem to be less effective.  Wal-Zyr doesn't work as well as Zyrtec, for example.  Same with CVS's Pepcid equivalent.  

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2 hours ago, Txzen said:

Not remotely true.

 

I've heard it's possible to recreate the same chemistry in different ways, and the side effects of the wrong way (for you) can be dangerous.  

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1 hour ago, Bullneck said:

I've heard it's possible to recreate the same chemistry in different ways, and the side effects of the wrong way (for you) can be dangerous.  

If it's FDA approved and not subject of its own new drug application ($$$$$$$), it's going to be virtually identical, including manufacturing.  In other words, if it's Generic.

Edited by TwiceHorn

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I was taking a proscribed medication that didn't have a generic when I first started trading it.  No not The blue pill. The generic came out and I got it. Within days I could tell it wasn't working. I went back to the name brand and it worked. So sometimes there is a difference. 

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1 hour ago, Mo Horn said:

I was taking a proscribed medication that didn't have a generic when I first started trading it.  No not The blue pill. The generic came out and I got it. Within days I could tell it wasn't working. I went back to the name brand and it worked. So sometimes there is a difference. 

hope it wasn't for spelling 

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6 hours ago, Liquor and Poker said:

I had a doctor once tell me generics only have to hit 80% equivalent dosage - meaning they can be off of a 10mg dose by 2mg or so.  Name brands don't do that.

That makes no sense to me but he was absolutely all "they've done tests you know" and all that.

I have personally found that nonprescription generics vary.  Some are indistinguishable.  Some seem to be less effective.  Wal-Zyr doesn't work as well as Zyrtec, for example.  Same with CVS's Pepcid equivalent.  

False. 

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4 hours ago, Bullneck said:

I've heard it's possible to recreate the same chemistry in different ways, and the side effects of the wrong way (for you) can be dangerous.  

False. Even if it’s synthesized differently to avoid patent infringement (the only reason to develop a novel synthesis, and genetics companies don’t usually spend the capital to do it when they can just wait for the parent to expire) it would still be fda approved including the identification and characterization of all trace impurities. 
 

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On 2/12/2020 at 11:28 PM, elfenix said:

all I got is acetylsalicylic acid, generic. See, I can get six hundred tablets of that for the same price as three hundred of a name brand. That makes good financial sense, good advice

I bet that party you are throwing is a tax write-off

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20 hours ago, HRSchenker said:

I'm a pharmacist and only buy generic. Brand names are for suckers.

My sister the pharmacist would fully agree, when they are available.

I seem to recall an analogy she used once.

Buying only name brand is like getting gas ONLY from Exxon when Hagy Mart down the road has the same gas for half the cost.

She did not call it Hagy Mart, for the record. I added that bit.

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With extremely few and rare individual exceptions, you are simply wasting money if you are choosing to use a brand over an FDA approved generic substitute. 

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Let me introduce you motherfuckers to the 1000 pill generic bottles of whatever your looking for on Amazon. Buy in bulk and save a literal shit ton.

https://www.amazon.com/SDA-Laboratories-Generic-Benadryl-Allergy/dp/B001X45QII/ref=mp_s_a_1_3?keywords=diphenhydramine+50mg+1000&qid=1581771227&sr=8-3

Edited by HOOK'EMHOOAH

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